The immune response in Taenia solium cysticercosis: protection and injury

Abstract

This article reviews current knowledge on the innate and acquired immune responses in human Taenia solium neurocysticercosis, highlighting the conditions that appear to be favourable for the survival or destruction of the parasite and for the benefit or injury to its host.

Crude antigen from Taenia crassiceps cysticercus used as heterologous antigen in ELISA and in EITB for neurocysticercosis diagnosis of patients from Paraná-Brazil

“…These results were contrary to previous studies by Barcelos and colleagues (2007), who used C. cellulosae as antigen and found higher frequencies with CSF than with serum. Discordant results corroborated other studies that showed that differences in reactivity could be related to immunological factors, localization and development phase of cysts, especially with existing immune-evasive mechanisms (Sciutto et al, 2007). Due to complex and diverse core epitope from antigens present in the parasite, the immune system could respond to distinct forms (Flisser, 2002).…”

“…The same assay was more sensitive when serum (96%) was used as compared to CSF (85%) from patients with active NCC. The reactivity of serum or CSF from patients with inactive, i.e., calcified cysticercus could be explained by the presence of antibodies that could persist for a long time after the parasite was eliminated by immune mechanisms and/or therapeutic drugs (Harrison, et al, 1989;Garcia et al, 1997;Sciutto et al, 2007). Even with CSF samples from patients with active NCC, the antigen detection by ELISA did not present good results.…”

Immunopathogenesis of Neurocysticercosis: Role of Cytokines

“…When cysticerci are lodged in CNS, a local immune response is induced by the host to secreted antigens [20]. These antigens may also reach to the peripheral blood from brain due to damage of BBB and as a result, a systemic immune response is initiated.…”

Infecção experimental em bovinos: cinética da produção de imunoglobulinas IgM e IgG contra cisticercose bovina e resposta inflamatória

“…A variação na resposta imunológica e o pico de produção de anticorpos em períodos distintos pode estar relacionado ao fato da habilidade do cisticerco sobreviver por longo período na presença da resposta imune do hospedeiro, por meio de secreção de antígenos que afetam a modulação do sistema imunitário do hospedeiro (HARRISON et al, 1989), habilidade que também é compartilhada pela Taenia solium (SCIUTTO et al, 2007 Em relação aos fibroblastos, foi possível constatar média maior de deposição ao redor de cisticercos inviáveis (54,2), quando comparadas à média dos cisticercos inviáveis (26,6) (p>0,05).…”