The APOA4 Thr₃₄₇→Ser₃₄₇ Polymorphism Is Not a Major Risk Factor of Obesity

Abstract

. The APOA4 Thr 347 3 Ser 347 polymorphism is not a major risk factor of obesity. Obes Res. 2005;13:2132-2138. Objective: The goal of this study was to assess the association between the APOA4 Thr 347 3 Ser 347 polymorphism and BMI and obesity. Research Methods and Procedures: Men and women (n ϭ 3320), randomly recruited in three independent population surveys from the north, east, and south of France, were genotyped for the APOA4 Thr 347 3 Ser 347 polymorphism. Results: There were 1327 overweight (825 men, 502 women) and 611 obese (313 men, 298 women) subjects. The prevalences of subjects carrying at least one Ser 347 allele (*/Ser 347 ) were 36.5%, 33.8%, and 34.3% in controls, overweight, and obese subjects, respectively (not significant), and those of the Ser 347 /Ser 347 genotype were 4.5%, 3.0%, and 2.2%, respectively (not significant). In both men and women, mean BMI and body weight were not significantly different among APOA4 genotypes. There was no evidence of heterogeneity among centers, smoking status, alcohol intake, physical activity, and educational level categories. In men, mean waist girth was lower in Ser 347 /Ser 347 (92.2 Ϯ 9.4 cm) than in Thr 347 carriers (95.9 Ϯ 10.9 cm; p ϭ 0.01), and plasma triglycerides levels were lower in Ser 347 (1.41 Ϯ 1.04 mM) than in Thr 347 /Thr 347 carriers (1.55 Ϯ 1.23 mM; p ϭ 0.01). Discussion: These results suggest that the APOA4 347Ser allele is not a major risk factor for obesity or overweight.

Association between angiopoietin-like 6 (ANGPTL6) gene polymorphisms and metabolic syndrome-related phenotypes in the French MONICA Study

“…A 20 mL blood sample was drawn on disodium EDTA after the subject had fasted for at least 10 h. Lipid and lipoprotein levels were all measured at the Purpan Hospital Biochemical Laboratory (Toulouse), as described elsewhere [15]. The homoeostasis model assessment of insulin resistance (HOMA-IR) index was calculated as the product of fasting plasma insulin (in U/mL) and fasting plasma glucose (in mmol/L), divided by 22.5 [17].…”

“…Participants were recruited from the WHO-MONICA population survey carried out from 1995 to 1997 in different regions of France: the Lille Urban Community in the north (Lille, n = 1195); the Bas-Rhin county in the east (Strasbourg, n = 1131); and the Haute-Garonne county in the south (Toulouse, n = 1182), as described elsewhere [15]. The study protocol was approved by the independent ethics committee of each respective region.…”

Study of the genetic variability of ZAC1 (PLAGL1) in French population-based samples

“…Subjects Participants were recruited as part of the WHO-MONICA population survey performed from 1995 to 1997 in different regions of France: the Lille Urban Community in the north (Lille, n ¼ 1195), the Bas-Rhin county in the east (Strasbourg, n ¼ 1131), and the HauteGaronne county in the south (Toulouse, n ¼ 1182), as previously described [32]. The sample-included individuals aged 35-65 randomly selected on electoral rolls after stratification by town size, gender and age to obtain 200 participants for each gender and 10-year age group (WHO-MONICA Project protocol) [33].…”

“…A 20 ml blood sample was drawn on disodium ethylenediaminetetraacetic acid (EDTA) after the individual had fasted for at least 10 h. Lipid and lipoprotein levels were all measured at the Purpan Hospital Biochemical Laboratory (Toulouse), as previously described [32].…”

Polimorfismos de los genes LEP, LDLR, APOA4, sus relaciones con sobrepeso, obesidad y riesgo de enfermedades crónicas en adultos del estado Sucre, Venezuela

“…Las variantes rs675 y rs5110 del gen APOA4 son mutaciones con cambio de sentido, es decir, implican cambios de aminoácido en la proteína (Tre367Ser y Gln380His, respectivamente) y, conjuntamente con el rs5095, se ha estudiado su su asociación con lípidos y lipoproteínas (20)(21)(22)(23), con el peso corporal, la dieta, los parámetros de la composición y la grasa corporal, así como con el síndrome metabólico (24)(25)(26)(27)(28).…”