The Humoral Response to Vascular and Nonvascular Allografts of Bone

Effects of freezing on bone histological morphology

“…Although frozen bone has been definitely considered for grafting procedures (Hou et al 2005;Jensen et al 2004;Tetta et al 2006), few researches have evaluated the effects of low temperature exerts on the histological morphology of bone (Stevenson et al 1996;Moreau et al 2000;Blottner et al 2001;Corcuera et al 2007; Moreau et al 2007). Therefore, it is relevant to discuss freezen biology, which developed in parallel to the improving of graft protocols.…”

Bone allograft: a cause for concern?

“…2,21 This variation may be related to antigenic disparity, notably between the cell-surface antigens of the major histocompatibility complex, although there is no clear clinical correlation, 22 and many grafts are essentially acellular. The links between the antigen in the bone and the biological responses to it are not known.…”

“…20 The resorption of a graft is sometimes dramatic; this may well be due to an immune response. 21 Less aggressive resorption is a normal biological reaction to bone graft and is part of neovascularisation, 22 but in allografts it probably contributes to fracture formation. 23 Tissue typing to try to reduce resorption and fracture is of uncertain value 22 and would be very difficult to implement.…”

“…21 Less aggressive resorption is a normal biological reaction to bone graft and is part of neovascularisation, 22 but in allografts it probably contributes to fracture formation. 23 Tissue typing to try to reduce resorption and fracture is of uncertain value 22 and would be very difficult to implement. In the UK, the supply of allograft relies heavily on femoral heads obtained during primary hip replacement and the most common indication for its use is revision of this procedure.…”

Análise da integração do aloenxerto ósseo de crânio criopreservado e irradiado, adicionado de medula óssea autógena: estudo experimental em coelhos

“…Em estudos animais há fortes evidências de que o aloenxerto ósseo induz uma reação imune (HALLORAN et al, 1979;STEVENSON, 1987;STEVENSON et al, 1996), porém a significância clínica desta reação, em humanos, não é clara. Segundo BAUER; MUSCHLER (2000), biópsias realizadas nos locais contendo aloenxertos ósseos revelam, algumas vezes, a presença de células de processo inflamatório crônico, porém a aparência histológica destas células não é específica e é difícil relacioná-las com certeza a uma reação imune.…”