The History of Medical Therapy of Ulcerative Colitis

Mudireddy, Prashant; Błoński, Wojciech; Lichtenstein, Gary R.

doi:10.1007/978-1-4939-1677-1_1

Cited by 2 publications

(2 citation statements)

References 152 publications

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“…While probiotics can bene t the intestinal tract, which related to host health. Probiotics prevent some bacteria pathogens from reaching the colonic lamina propria through competitive inhibition, and stimulate the mucosal immune system at the same time (Mudireddy et al, 2014). Kai et al (2017) reported that L. plantarum administration could relieve the duodenal in ammation of mice with enteritis (Kai et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Lactiplantibacillus plantarum DLPT4 Protects Against Cyclophosphamide-Induced Immunosuppression in Mice by Regulating Immune Response and Intestinal Flora

Song

Sun

et al. 2023

Probiotics & Antimicro. Prot.

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In this study, the strain Lactiplantibacillus plantarum DLPT4 was investigated for the immunostimulatory activity in cyclophosphamide (CTX)-induced immunosuppressed BALB/c mice. L. plantarum DLPT4 was administered to BALB/c mice by oral gavage for 30 days, and CTX was injected intraperitoneally from 25th to 27th days. Intraperitoneally CTX injection caused the damage to the thymic cortex and intestines, and the immune dysfunction of the BALB/c mice. While L. plantarum DLPT4 oral administration exerted immunoregulating effects evidenced by increasing the serum immunoglobulin A (IgA), IgG and IgM levels, and reducing the expression of pro-in ammatory factors (IL-6, IL-1β and TNF-α) of the BALB/c mice with intraperitoneally CTX injection.The results of the BALB/c mice feces metagenome-sequencing showed that L. plantarum DLPT4 oral administration can regulate the intestinal microbial community by changing the ratio of Lactiplantibacillus and Bi dobacterium.Meanwhile, the abundance of carbohydrate enzyme (CAZyme), immune diseases metabolic pathways and p38 and AP-1 MAPK signaling pathways were enriched in the BALB/c mice with L. plantarum DLPT4 oral administration.In conclusion, L. plantarum DLPT4 administration ameliorated CTX-induced immunosuppression in BALB/c mice by regulating gut microbiota, and further in uencing the abundance of carbohydrate esterase in the intestinal ora and increasing the immune metabolic activity. L. plantarum DLPT4 could be used as promising probiotics to regulate immune response. Highlights• Lactiplantibacillus plantarum DLPT4 oral administration could increase the serum immunoglobulin A (IgA), IgG levels of CTX-induced mice.• Lactiplantibacillus plantarum DLPT4 oral administration restored gut microbiota of CTX-induced immunosuppression in mice • Lactiplantibacillus plantarum DLPT4 oral administration could enrich the abundance of carbohydrate enzyme (CAZyme), immune diseases metabolic pathways and p38 and AP-1 MAPK signaling pathways.

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Section: Introductionmentioning

confidence: 99%

Lactiplantibacillus plantarum DLPT4 Protects Against Cyclophosphamide-Induced Immunosuppression in Mice by Regulating Immune Response and Intestinal Flora

Song

Sun

et al. 2023

Probiotics & Antimicro. Prot.

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“…Patients with ulcerative colitis often require daily multigram doses of 5-ASA to achieve therapeutic concentrations in the colon, 4 so it is desirable to minimize the amount of excipients or adjuvant molecules in the dosage form. Among approved prodrugs of 5-ASA, olsalazine is the most efficient by weight, since it is a homodimer of two 5-ASA molecules, whereas sulfasalazine and balsalazide are heterodimers of 5-ASA and carrier molecules.…”

mentioning

confidence: 99%

Calcium Coordination Solids for pH‐Triggered Release of Olsalazine

et al. 2017

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Calcium coordination solids were synthesized and evaluated for delivery of olsalazine (H4olz), an anti‐inflammatory compound used for treatment of ulcerative colitis. The materials include one‐dimensional Ca(H2olz)⋅4 H2O chains, two‐dimensional Ca(H2olz)⋅2 H2O sheets, and a three‐dimensional metal‐organic framework Ca(H2olz)⋅2DMF (DMF=N,N‐dimethylformamide). The framework undergoes structural changes in response to solvent, forming a dense Ca(H2olz) phase when exposed to aqueous HCl. The compounds Ca(H2olz)⋅x H2O (x=0, 2, 4) were each pressed into pellets and exposed to simulated gastrointestinal fluids to mimic the passage of a pill from the acidic stomach to the pH‐neutral intestines. All three calcium materials exhibited a delayed release of olsalazine relative to Na2(H2olz), the commercial formulation, illustrating how formulation of a drug within an extended coordination solid can serve to tune its solubility and performance.

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The History of Medical Therapy of Ulcerative Colitis

Cited by 2 publications

References 152 publications

Lactiplantibacillus plantarum DLPT4 Protects Against Cyclophosphamide-Induced Immunosuppression in Mice by Regulating Immune Response and Intestinal Flora

Lactiplantibacillus plantarum DLPT4 Protects Against Cyclophosphamide-Induced Immunosuppression in Mice by Regulating Immune Response and Intestinal Flora

Calcium Coordination Solids for pH‐Triggered Release of Olsalazine

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