Calcium Coordination Solids for pH‐Triggered Release of Olsalazine

Levine, Dana J.; Gonzalez, Miguel I.; Legendre, Christina M.; Runčevski, Tomče; Oktawiec, Julia; Colwell, Kristen A.

doi:10.1002/cmdc.201700540

Cited by 5 publications

(2 citation statements)

References 51 publications

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“…Olsalazine (H 2 OLZ), a prodrug of the anti-inflammatory 5-aminosalicylic acid (5-ASA), is prescribed as the first line of treatment for patients with idiopathic inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. [122] To solve the problem regarding sustained release of olsalazine in human body, Long and co-workers [123] (3). After being pressed into pellets and exposed to simulated gastrointestinal fluids, all three materials exhibited a delayed release of olsalazine relative to Na 2 (H 2 OLZ) which released more than 90% olsalazine.…”

Section: Drug Delivery and Other Biomedical Applicationsmentioning

confidence: 99%

Calcium‐Based Metal–Organic Frameworks and Their Potential Applications

Xian

Lin

Wang

et al. 2020

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Metal-organic frameworks (MOFs) built on calcium metal (Ca-MOFs) represent a unique subclass of MOFs featuring high stability, low toxicity, and relatively low density. Ca-MOFs show considerable potential for molecular separations, electronic, magnetic, and biomedical applications, although they are not investigated as extensively as transition metal-based MOFs. Compared to MOFs made of other groups of metals, Ca-MOFs may be particularly advantageous for certain applications such as adsorption and storage of light molecules because of their gravimetric benefit, and drug delivery due to their high biocompatibility. This review intends to provide an overview on the recent development of Ca-MOFs, including their synthesis, crystal structures, important properties, and related applications. Various synthetic methods and techniques, types of building blocks, structure and porosity features, selected physical properties, and potential uses will be discussed and summarized. Representative examples will be illustrated for each type of important applications with a focus on their structure-property relations.ethylene/acetylene, propane/propylene) through highly selective size exclusion mechanism, [6,11,24] which has not been achieved by conventional adsorbent materials. The potential uses of MOFs depend on their pore structure (pore size/pore shape), surface functionality, as well as the type of metal centers and ligands.Calcium-based metal-organic frameworks (Ca-MOFs) represent a subgroup of MOFs with calcium as metal centers. Unlike MOFs built on transition and post-transition metals (Zr, Fe, Co, Ni, Cu, Zn, etc.) which tend to form commonly observed SBUs and topology and, therefore allow for successful design and implementation of targeted structure and functionality, the prediction of coordination geometry and structural topology of Ca-MOFs are much more challenging. This could be attributed to the fact that the bonding interactions between calcium and organic ligands (commonly carboxylates or phosphates) are more ionic, and thus the coordination mode of calcium and the topology of Ca-MOFs largely rely on the nature of the organic ligands as well as the synthetic conditions. However, Ca-MOFs possess several advantages compared to those built on transition metals: 1) Ca-MOFs generally feature high thermal stability because of its high electropositivity which leads to strong, ioniclike bonds with organic ligands (e.g., carboxylates). 2) Calcium is earth-abundant (3.4% of Earth's crust) and nontoxic, making Ca-MOFs relatively inexpensive and environmentally safe, thus especially promising for biological related applications. 3) The lightweight of calcium metal offers gravimetric benefit for gas adsorption/storage related applications.To date, more than 150 Ca-MOFs have been reported (Table 1). These MOFs bear different structural features and have been evaluated for various applications, including molecular separation, drug delivery and controlled release, chemical sensing, and proton conductivity, to name a few. In this...

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Section: Drug Delivery and Other Biomedical Applicationsmentioning

confidence: 99%

Calcium‐Based Metal–Organic Frameworks and Their Potential Applications

Xian

Lin

Wang

et al. 2020

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“…Calcium, the fifth most abundant element in the earth’s crust, fills many important roles in natural and synthetic chemistry . Ca 2+ is the main cation in bone, shell, and microstructured biomaterials with remarkable mechanical properties. − It is often employed as an enzymatic cofactor, including within the photosynthetic oxygen-evolving complex (OEC), and is considered “the best communicator” in biological signaling. − Calcium is a key component in cements and many industrial chemical processes, and molecular calcium complexes can effect alkene and imine hydrogenations, polymerizations, and even the nucleophilic alkylation of benzene. − Partly because it is such a “green” metal compared to the often rare or toxic stalwarts of transition-metal chemistry, interest in calcium catalysts and metal–organic frameworks is increasing. ,,− …”

Section: Introductionmentioning

confidence: 99%

Calcium Valence-to-Core X-ray Emission Spectroscopy: A Sensitive Probe of Oxo Protonation in Structural Models of the Oxygen-Evolving Complex

et al. 2019

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Calcium is an abundant, nontoxic metal that finds many roles in synthetic and biological systems including the oxygen-evolving complex (OEC) of photosystem II. Characterization methods for calcium centers, however, are underdeveloped compared to those available for transition metals. Valence-to-core X-ray emission spectroscopy (VtC XES) selectively probes the electronic structure of an element’s chemical environment, providing insight that complements the geometric information available from other techniques. Here, the utility of calcium VtC XES is established using an in-house dispersive spectrometer in combination with density functional theory. Spectral trends are rationalized within a molecular orbital framework, and Kβ2,5 transitions, derived from molecular orbitals with primarily ligand p character, are found to be a promising probe of the calcium coordination environment. In particular, it is shown that calcium VtC XES is sensitive to the electronic structure changes that accompany oxo protonation in Mn3CaO4-based molecular mimics of the OEC. Through correlation to calculations, the potential of calcium VtC XES to address unresolved questions regarding the mechanism of biological water oxidation is highlighted.

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A New Three‐dimensional Metal‐organic Framework based on Dinuclear Rare Earth Cluster and Olsalazine

Zhang

Zhong

Liu

et al. 2019

Zeitschrift anorg allge chemie

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A new microporous metal organic frameworks Eu2(olz)3·7(DMF), based on olsalazine, has been successfully designed and synthesized. Eu‐olz has three‐dimensional structure with dinuclear rare earth cluster and drug molecule olsalazine as ligand, and features as low toxic MOF materials. The Eu‐olz exhibits weak fluorescent emission which can be ascribed to the luminescence of the organic ligand.

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Calcium Coordination Solids for pH‐Triggered Release of Olsalazine

Cited by 5 publications

References 51 publications

Calcium‐Based Metal–Organic Frameworks and Their Potential Applications

Calcium‐Based Metal–Organic Frameworks and Their Potential Applications

Calcium Valence-to-Core X-ray Emission Spectroscopy: A Sensitive Probe of Oxo Protonation in Structural Models of the Oxygen-Evolving Complex

A New Three‐dimensional Metal‐organic Framework based on Dinuclear Rare Earth Cluster and Olsalazine

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