The histopathology of the kidney in toxaemia. Serial renal biopsies during pregnancy, puerperium and several years postpartum

Intrarenal Vascular Lesions Associated with Pre-Eclampsia

“…Oc casional patchy thickening of the basement membrane has however been reported in severe cases of pre-eclampsia [5], Electrondense material almost certainly fibrin or one of its derivatives is frequently observed on the endothelial surface of the basement membrane and fibrin has also been noted both between and within the endothelial cells [8][9][10][11][12]21]. In addition, occasional translucent endothelial zones may be detected which may well re present a macromolecular arrangement of precipitated fibrinogen.…”

“…Although there is now considerable agree ment with regard to the histological [5][6][7][8]16] and electron-microscopic appearances of the renal cortex [8][9][10][11][12] associated with the acute stage of pre-eclampsia reports of the immu nological findings associated with this disorder are by no means consistent [8,[13][14][15],…”

Distant Evolution of Kidney Arteriolar Lesions and Hypertension after Pregnancy Toxemia

“…Other deposits (IgA. IgE and Ci), sometimes seen in early biopsies, nearly always disappeared in our cases and in most of cases reported in the literature [3,14], and are in any case of low intensity [17].…”

“…Disappearance of other glomerular lesions is disputed. Mesangium hypertrophy remains in related cases 1-4 years after delivery [18], and increases in late biopsies [3]. In our patients, this mesangial hypertrophy remains in most of the time.…”

Nonamyloidotic Fibrillar Glomerulopathy and Recurrent Gestational Anasarca

“…The renal biopsy finding of fibrillar nephropathy was therefore surprising. Congored-negative microfibrils have been described in pre eclampsia [1,2], the hemolytic uremic syndrome [2. 3], malignant hypertension [2], lupus nephritis [4], cryo globulinemia [5], paraproteinemias [5,6], diabetes mel- Fig.…”