Distant Evolution of Kidney Arteriolar Lesions and Hypertension after Pregnancy Toxemia

Zech, P; Colon, S; Deteix, P; Blanc-Brunat, N

doi:10.1159/000182005

Cited by 3 publications

(1 citation statement)

References 9 publications

(11 reference statements)

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“…A PubMed search for the terms “endotheliitis” and “endothelialitis” showed a first use in 1958 when they referred to retinal lesions [ 63 ]. Since the 1980s, they were also applied to vascular changes in the kidney [ 64 ] and liver; the latter are described as “attachment of lymphoid cells to the endothelium of central or portal veins” [ 65 ]. In a recent review on vascular endothelialitis in infectious diseases, the rather vague definition “inflammation of the endothelium lining the lumen of blood vessels in association with a direct consequence of infectious pathogen invasion and the host immune response” was suggested [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

The Stereotypic Response of the Pulmonary Vasculature to Respiratory Viral Infections: Findings in Mouse Models of SARS-CoV-2, Influenza A and Gammaherpesvirus Infections

Neck

Penrice-Randal

Clark

et al. 2023

Viruses

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The respiratory system is the main target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 19 (COVID-19) where acute respiratory distress syndrome is considered the leading cause of death. Changes in pulmonary blood vessels, among which an endothelialitis/endotheliitis has been particularly emphasized, have been suggested to play a central role in the development of acute lung injury. Similar vascular changes are also observed in animal models of COVID-19. The present study aimed to determine whether the latter are specific for SARS-CoV-2 infection, investigating the vascular response in the lungs of mice infected with SARS-CoV-2 and other respiratory viruses (influenza A and murine gammaherpesvirus) by in situ approaches (histology, immunohistology, morphometry) combined with RNA sequencing and bioinformatic analysis. Non-selective recruitment of monocytes and T and B cells from larger muscular veins and arteries was observed with all viruses, matched by a comparable transcriptional response. There was no evidence of endothelial cell infection in any of the models. Both the morphological investigation and the transcriptomics approach support the interpretation that the lung vasculature in mice mounts a stereotypic response to alveolar and respiratory epithelial damage. This may have implications for the treatment and management of respiratory disease in humans.

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Section: Discussionmentioning

confidence: 99%

The Stereotypic Response of the Pulmonary Vasculature to Respiratory Viral Infections: Findings in Mouse Models of SARS-CoV-2, Influenza A and Gammaherpesvirus Infections

Neck

Penrice-Randal

Clark

et al. 2023

Viruses

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From preeclampsia to renal disease: a role of angiogenic factors and the renin-angiotensin aldosterone system?

Graaf

Toering

Faas

et al. 2012

Nephrology Dialysis Transplantation

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Complicating up to 8% of pregnancies, preeclampsia is the most common glomerular disease worldwide and remains a leading cause of infant and maternal morbidity and mortality. Although the exact pathogenesis of this syndrome of hypertension and proteinuria is still incomplete, a consistent line of evidence has identified an imbalance of proangiogenic and anti-angiogenic proteins as a key factor in the development of preeclampsia. Furthermore, more attention has been recently addressed to the renin-angiotensin aldosterone system (RAAS), to provide understanding on the hypertension of preeclampsia. The imbalance of the RAAS and the imbalance between angiogenic and anti-angiogenic factors, which may be both common to preeclampsia and chronic kidney disease (CKD), might explain why a history of preeclampsia predisposes women to develop CKD. In this review, we briefly describe the characteristics of preeclampsia with a focus on the mechanisms of angiogenesis and the RAAS and its role in the pathogenesis of preeclampsia. Our main focus will be on the intriguing association between preeclampsia and the subsequent increased risk of developing CKD and on the potential mechanisms by which the risk of CKD is elevated in women with a history of preeclampsia.

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Preeclampsia: A Clinicopathologic Study of 23 Cases

Hill

Zimmerman

Fairley

et al. 1988

Clinical and Experimental Hypertension. Part B: Hypertension in

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Distant Evolution of Kidney Arteriolar Lesions and Hypertension after Pregnancy Toxemia

Cited by 3 publications

References 9 publications

The Stereotypic Response of the Pulmonary Vasculature to Respiratory Viral Infections: Findings in Mouse Models of SARS-CoV-2, Influenza A and Gammaherpesvirus Infections

The Stereotypic Response of the Pulmonary Vasculature to Respiratory Viral Infections: Findings in Mouse Models of SARS-CoV-2, Influenza A and Gammaherpesvirus Infections

From preeclampsia to renal disease: a role of angiogenic factors and the renin-angiotensin aldosterone system?

Preeclampsia: A Clinicopathologic Study of 23 Cases

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