Intrarenal Vascular Lesions Associated with Pre-Eclampsia

Persistent Abnormalities of Fibrinolytic Activity and Platelet Function in Patients With Reversible Oestrogen‐associated Hypertension

“…The significance of these abnormalities in relation to the development of hypertension and to the intrarenal vascular disease found in these patients is discussed.PREVIOUS studies from this department showed the presence of both structural and haemodynamic abnormalities of the intrarenal circulation in patients with a previous history of oestrogen-associated hypertension . Similar abnormalities were also noted in patients with the loin-pain-haematuria syndrome and in patients with a previous history of pregnancy-associated hypertension (Aber, 1978;Burden et al, 1979). In the latter two groups of patients, abnormalities of platelet function and fibrinolysis and/or platelet sequestration by the kidneys were found (Jones et al, 1977;Al-Khader et a,, 1979).…”

Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension

“…This is a condition characterized by a marked rise in serum uric acid in the mother during the third trimester, elevated levels of uric acid in the fetus, and a high frequency of IUGR and low birth weights. Not surprisingly, children of preeclamptic mothers have an increased frequency for the later development of hypertension [58,59]. The rise in uric acid that occurs in the third trimester in preeclampsia corresponds well with the period when nephron development is impaired in low-birth-weight infants [10].…”

Complicaciones renales en el embarazo

“…Insignes fisiólogos han comentado que ésta es la única situación conocida en la que el filtrado glomerular pueda incrementarse en un 50 % por períodos prolongados de tiempo 23 • El mecanismo por el que estas alteraciones pueden producirse ha sido muy discutido implicándose gran número de factores, pero parece ser que el factor más importante son las alteraciones que se observan en el volumen del espacio extracelular y que comentaremos más adelante. El , aumento en el filtrado glomerular implica una mayor 1 capacidad depuradora y ésta conlleva una disminución de las tasas plasmáticas de urea y creatinina, dato de gran valor práctico a la hora de estudiar la función renal de la embarazada normal o complicada. Estudios realizados 22 en embarazadas normotensas encuentran la tasa plasmática media de urea en 13 ± 3 y de creatinina en 0,67 ± 0,14 mg/100 ml.…”