The histopathogenesis of the nephrosis‐nephritis syndrome

SUMMARYUsing immunohistochemical methods, we studied the nephropathogenicity of the infectious bronchitis virus (IBV)-strain V1648-and the leukocyte phenorypes in the pathological lesions in the kidneys and the trachea formed after inoculation with this virus strain. One-day-old WLA chickens were intravenously inoculated, and after 5, 7 and 11 days their kidneys, trachea and lungs were removed. Monoclonal antibodies were used to detect viral antigen, and lymphoid and non-lymphoid cell populations. In serial sections, the detection of the viral antigen was correlated to the phenotypes of the cells. At days 5 and 7 after inoculation, viral antigen was detected in the epithelium and the interstitium of the kidney tubuli and in the epithelium of the trachea. The infiltrated cells in these tissues were mainly of the T cell phenotype. The cellular immune reaction was correlated with the detection of viral antigen.

Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Leukocyte subpopulations in kidney and trachea of chickens infected with infectious bronchitis virus

Janse¹,

Roozelaar²,

Koch³

1994

“…Lymphoid foci can be present 2 weeks after the beginning of an infection, according to Pohl (1974). Ball et al (1969) and Shah et al (1969) are of the opinion that the foci disappear after a time, if the stimulating factor has gone.…”

Section: Discussionmentioning

confidence: 99%

A bacterial proventriculitis in canaries(Serinus canaria)

Herck¹,

Duijser²,

Zwart³

et al. 1984

SUMMARYA description is given of the pathomorphology and pathomorphogenesis of a bacterial infection of the proventriculus of canaries. The cause appeared to be a large, rod-shaped, Grampositive bacterium, in which no spore formation could be observed. Cultivation in vitro has not as yet been achieved. Thirty % of the 30 canaries examined contained this bacterium in the proventriculus. In the rest of the digestive tract much smaller numbers were found. The bacteria were associated with a proliferative inflammatory reaction in the proventriculus. The infected proventriculi had an increased pH and an altered synthesis of mucopolysaccharides. The coilin layer of the gizzard was thinner in the infected canaries than in the control group, possibly as a result of the increased pH in the proventriculus. INTRODUCTIONDuring post-mortem examination of canaries, the mucosa of the proventriculus was found in several to be covered with thick, whitish mucus, in which large numbers of large, rod-shaped microorganisms were found.

“…Renal lesions consisting of tubular degeneration and an inflammatory cell reaction in the interstitium and tubules have been described in IBV-infected chickens (Chong & Apostolov, 1982;Fulton et al, 1993;Pohl, 1974;Purcell et al, 1976;Siller & Cumming, 1974). It was suggested that the renal lesions might be initiated as nephrosis that progresses to nephrosis-nephritis and lastly to interstitial nephritis (Chen et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Histopathology and immunohistochemistry of renal lesions due to avian infectious bronchitis virus in chicks uninoculated and previously inoculated with highly virulent infectious bursal disease virus

Chen

Itakura

1997

SUMMARYA nephropathogenic strain of infectious bronchitis virus (IBV) was inoculated intra-tracheally into 14-day-old specific-pathogen-free chicks or ones previously inoculated with highly virulent infectious bursal disease virus (IBDV) at 7 days of age. The renal lesions were examined histopathologically and immunohistochemically at intervals up to 30 days post-inoculation. The mortality was 20% in the IBDV + IBV-inoculated group, but not in the IBV-inoculated one. Swollen and pale kidneys due to IBV infection were more severe and of longer duration in dually infected chicks. At the early stage of infection, the histopathological changes in the kidneys were similar in both groups, but the ducto-tubular damage was more severe in the dually infected chicks. At the late stage of infection, the renal lesions were characterized by chronic interstitial nephritis with formation of lymphoplasmacytic nodules in IBV-inoculated chicks and by chronic active nephritis which consisted of tubular degeneration, lymphoid cell reaction and interstitial fibrosis in IBDV + IBVinoculated ones. More IBV antigen-positive cells persisted longer in the kidneys of dually infected chicks than in those of IBV-inoculated ones.