The histologic effect of topically applied acetylsalicylic acid on bone healing in rats

The effect on bone repair of aspirin cones placed in extraction sockets in dogs: a histopathologic study

“…Contrary to what we observed in our previous labeling research (Baratieri & Deli 1976), our histopathologic results agree with the findings of Nordenram & Bang (1970) rather than with Carroll & Melfi (1972). In contrast to Carroll & Melfi (1972) we observed, as did Nordenram & Bang (1970), an inflammatory response of: limited duration as well as reduced osteoclastic activity inside and around the aspirin-containing cavities. Subsequently the remodeling activity soon Figs.…”

“…In these studies, which experimental and control cavities; no comresemble each other rather closely, the plications were observed. Two years later, course of the patients was followed until Carroll & Melfi (1972), on the contrary, clinical resolution had been obtained. On observed that in the cavities containing the other hand, the histopathologic aspects aspirin there was an inflammatory of the reparative response of the bone to response and osteoclastic activity of this drug have not been fully described.…”

Effect of Aspirin on Bone Healing in a Rabbit Ulnar Osteotomy Model

“…This delivery method likely produced high local concentrations, which were not measured 19,20 . Two additional in vivo studies examined the effect of oral aspirin on bone healing in animal models.…”

“…Previous animal studies have shown aspirin to inhibit bone healing at high doses [19][20][21][22][23] . To our knowledge, our study is the first to demonstrate inhibition of bone healing by aspirin in an animal model within a dosing range equivalent to that typically employed in humans.…”

“…The effect of aspirin on bone healing was examined in four animal studies and a human in vitro study [19][20][21][22][23] . All of these studies demonstrated an inhibitory effect of aspirin on bone healing.…”