The effect on bone repair of aspirin cones placed in extraction sockets in dogs: a histopathologic study

Abstract

Four canines of eight 2-year-old dogs were extracted surgically, a mucoperiosteal flap being raised. A standardized pair of the post-extraction cavities were filled with three aspirin cones, the other pair being used as controls. The flaps were sutured with surgical gut. The dogs were killed at intervals of 2, 4, 6 and 8 weeks; bone blocks including the cavities were resected and decalcified for histologic examination; serial sections were stained with hematoxylin and eosin. Microscopic observation on 2 week samples showed an inflammatory response with granulation tissue in both experimental and control cavities with delayed bone apposition in cavities filled with aspirin cones. The 4, 6 and 8 week samples did not show any major difference between the experimental and control cavities. We observed a decrease in infiltrating of cells followed in both by a similarly increasing amount of fibrous tissue and bone remodeling. These results were due perhaps to the details of the experimental method as the suture allowed aspirin to stay in the cavities for only a short time (2-3 days), as occurs in clinical practice.

Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing

“…Because NSAIDs are commonly used to treat skeletal injuries and pain, their effects on fracture healing have been examined by many investigators over the past 35 years [20,21,22,23,24,25,26,27,28]. These studies have shown that the administration of NSAIDs and COX-2 selective NSAIDs can impair or delay bone healing and decrease the mechanical integrity of the healing bone.…”

“…However, the scope of this study was limited to testing a single time point (six weeks) and one outcome parameter. Other studies have shown that non-selective NSAIDs delay fracture healing in larger animal models such as rabbits and dogs [21,28,30]. …”

Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats

“…A small number of experimental investigations have suggested the deleterious effect of conventional NSAIDs on alveolar bone healing 2,30 and some clinical assessments have reported no significant difference in the rate of bone healing following administration of this kind of drug 3,4,17 .…”

Prostaglandins and bone: potential risks and benefits related to the use of nonsteroidal anti-inflammatory drugs in clinical dentistry

“…In the 1970s, the effects of acetylsalicylic acid (44) and indomethacin (45) were evaluated. A histological study was also conducted to investigate the effects on bone repair of long-term treatment with aspirin cones placed in the extraction sockets of dogs (46). The authors reported delayed bone formation in the sockets filled with aspirin cones in 2-week samples, but not after long-term treatment (4, 6 and 8 weeks).…”