Effect of Aspirin on Bone Healing in a Rabbit Ulnar Osteotomy Model

Abstract

In a rabbit ulnar osteotomy model, aspirin delayed bone healing with a threshold equivalent to a human dose of 325 mg.

Any Cortical Bridging Predicts Healing of Tibial Shaft Fractures

“…This reliability is much greater than that previously reported for radiographic assessments of tibial union and surgeons' general impression of healing (kappa = 0.6 and 0.67, respectively) and is similar to that found for the RUST score (Radiographic Union Score for Tibial fractures) 21,23 . Agreement for the more stringent criteria of bridging of two (kappa = 0.81) and three cortices (kappa = 0.85) remained substantial and was similar to that for cortical bridging in previous reports 21,28 . The reliability of the assessment of the exact number of cortices bridged was much lower (0.58) than that of the above dichotomous criteria.…”

Neurochemical Plasticity of nNOS-, VIP- and CART-Immunoreactive Neurons Following Prolonged Acetylsalicylic Acid Supplementation in the Porcine Jejunum

“…It is a widely recognized dose used in experiments aimed at understanding the effects of acetylsalicylic acid on gastrointestinal function. A similar dose was used in pigs [16], rats [78], rabbits [79] and mice [80]. High dose administration aims to provide a research model for people abusing aspirin as well as for patients receiving long-term acetylsalicylic acid as a result of cardiovascular disorders.…”

Efek Pemberian Meloxicam Yang Diberikan Selama Fase Inflamasi Terhadap Proses Penyembuhan Tulang Tikus Paska Open Reduction Internal Fixation K-Wire Dinilai Secara Radiologis

“…Di Amerika Serikat, hampir 111.400.000 resep OAINS dibuat setiap tahunnya dengan nilai penjualan sebesar hampir 5 miliar Dolar Amerika Serikat. [1][2][3] Di Amerika Serikat, angka kejadian delayed union atau nonunion diperkirakan mencapai 5% sampai 10% dari seluruh kasus patah tulang. Banyak faktor yang dapat mengintervensi proses penyembuhan patah tulang dan mengakibatkan terjadinya delayed union atau nonunion.…”

“…Banyak faktor yang dapat mengintervensi proses penyembuhan patah tulang dan mengakibatkan terjadinya delayed union atau nonunion. [1][2][3] Faktor yang menyebabkan kegagalan penyembuhan tulang dibagi menjadi faktor biologis dan faktor mekanis. Faktor biologis berupa pola fraktur, fraktur terbuka atau tertutup, infeksi, penyakit kronis, penyakit metabolik dan penyakit gangguan imunitas, pola hidup seperti merokok dan penyalahgunaan alkohol.…”