The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride

Bayram, İrfan; Erten, Remzi; Bayram, Yasemin; Bulut, Gülay; Özbek, Hanefí

doi:10.4318/tjg.2011.0312

Cited by 2 publications

(1 citation statement)

References 29 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study showed that HFD induced hepatocellular degeneration and steatosis and CGJ and OGJ reduced the liver damage, where OGJ was more effective in this protection. It was previously found that Vitis vinifera extract was able to significantly reduce CCl 4 -associated ballooning degeneration and apoptotic cell counts in the liver of rats [ 63 ]. Moreover, in earlier studies, naringenin, a bioflavonoid present in grapes, and vitamins C and E significantly improved the altered biochemical and histopathological changes in the liver of cadmium-intoxicated rats [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective and Antioxidant Potential of Organic and Conventional Grape Juices in Rats Fed a High-Fat Diet

et al. 2014

View full text Add to dashboard Cite

The objective of this study was to investigate the antioxidant and hepatoprotective effect of the chronic use of conventional (CGJ) or organic (OGJ) grape juice from the Bordeaux variety grape on oxidative stress and cytoarchitecture in the liver of rats supplemented with a high-fat diet (HFD) for three months. The results demonstrated that HFD induced an increase in thiobarbituric acid-reactive substances (TBARS), catalase (CAT) activity and 2′,7′-dihydrodichlorofluorescein (DCFH) oxidation and a decrease in sulfhydryl content and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. HFD also induced hepatocellular degeneration and steatosis. These alterations were prevented by CGJ and OGJ, where OGJ was more effective. Therefore, it was concluded that HFD induced oxidative stress and liver damage and that the chronic use of grape juice was able to prevent these alterations.

show abstract

Section: Discussionmentioning

confidence: 99%