Hepatoprotective and Antioxidant Potential of Organic and Conventional Grape Juices in Rats Fed a High-Fat Diet

Buchner, I.; Medeiros, Niara da Silva; Lacerda, Denise dos Santos; Normann, Carlos Augusto B. M.; Gemelli, Tanise; Rigon, Paula; Wannmacher, Clóvis Milton Duval; Henriques, João Antônio Pêgas; Dani, Caroline; Funchal, Cláudia

doi:10.3390/antiox3020323

Cited by 28 publications

(27 citation statements)

References 60 publications

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“…CAT and SOD was increased. Similar results were observed in another research when grape fruit juice was given to hyperlipidemic mice that resulted in decreased oxidative stress and increased serum level of antioxidant enzymes [21].…”

Section: Discussionsupporting

confidence: 75%

Pharmacological evaluation of <i>Vernonia elaeagnifolia</i> (Asteraceae) leaves in hyperlipidemic albino rabbits

Sultana¹,

Khaliq²,

Rehman³

et al. 2017

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 75%

Pharmacological evaluation of <i>Vernonia elaeagnifolia</i> (Asteraceae) leaves in hyperlipidemic albino rabbits

Sultana¹,

Khaliq²,

Rehman³

et al. 2017

Trop. J. Pharm Res

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“…The same result was observed in a study with pregnant ewes submitted to a diet supplemented with foods rich in polyphenols but in serum [15]. This fact could be explained by the fact that when in high doses, the polyphenols may present pro-oxidant action [41][42][43]. However, other studies show the benefit of consumption of products rich in polyphenols, such as grape juice [3,4,7,9,44,45].…”

Section: Resultsmentioning

confidence: 54%

“…Our data corroborate with studies conducted with different natural compounds, such as grape juice, propolis and soy protein, where in all the studies, it was observed an increase in the thiol groups (-SH) after the treatment in question [44,48,49]. However, a study conducted by Bubols et al [15] evidenced a decrease in levels of thiol groups in serum of pregnant ewes submitted to a diet supplemented with foods rich in polyphenols, showing that, when in high doses, the polyphenols may present pro-oxidant action [15,[41][42][43]. The cells have several antioxidant enzymes, including SOD, CAT, GPx, and GST to prevent the reactive species of oxygen damage [50].…”

Section: Resultsmentioning

confidence: 86%

Effect of Chronic Treatment with Grape Juice during Pregnancy and Nursing in Central Nervous System of Female Wistar Rats

Dani¹

2017

JNHFE

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This study aimed to evaluate the effect of chronic treatment with purple grape juice (Vitis labrusca L.), by free access or gavage, during the pregnancy and lactation on the behavior and parameters of oxidative stress on the central nervous system tissues of female Wistar rats. The female Wistar rats (n=40) were mated, and the pregnancy was confirmed by vaginal swab. After the pregnancy was confirmed, the animals were randomly divided into 4 groups: water (free access); water (gavage); juice (free access); juice (gavage). The animals were treated with water or juice (free access or gavage). The gavage was done once a day at a dose of 7µL/g of body weight. On the open field test, we observed that the grape juice was able to increase the latency time, decrease the time to rearing and lower the time and the frequency crossing. In the plus maze test, the grape juice was able to decrease the time spent in the open arm, which suggests anxiolytic characteristics to the juice. On the oxidative stress analyzes, the grape juice was capable to reduce the lipid per oxidation, however, it was not able to reduce the protein oxidation induced by the damage provoke by the gavages. Grape juice increased non-enzymatic defenses (sulfhyidryl content) in the cerebral cortex. The activity of the SOD and CAT enzymes were modulated by grape juice differently depending on the tissue evaluated. We observed that the SOD/CAT ratio also presented a different behavior in each of the tissues. We conclude that pregnancy can be an important factor to alter various parameters, on behavioral or biochemical assays. However, we found that grape juice was able to improve some parameters, reducing the stress caused by gavage in brain structures.

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“…Furthermore, an increase in MDA and a decrease in SOD, CAT, GPx level, induction of hepatocellular degeneration and steatosis were recorded in rats supplemented with a high-fat diet. On the other hand, these negative changes were improved in animals fed with grapefruit juice [41]. It has been stated that grapefruit juice reduced lipid peroxidation marker, MDA and increased GSH in Streptozotocin-induced diabetic rats [38].…”

Section: Discussionmentioning

confidence: 97%

Effect of Grapefruit Juice on Aluminum-Induced Hepatotoxicity in Albino Rats: Histological, Ultrastructural and Histochemical Assessment

Al-Amoudi¹

2017

ABB

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The present work studied the effect of grapefruit juice (Citrus) on the hepatotoxicity of AlCl 3 . Four groups of adult male albino rats were used. Group I contained 10 rats and remained as a control group; Group II: 10 rats were included and orally administered with grapefruit juice at a dose level of 27 ml/kg of body weight per day for 6 weeks; Group III: 10 rats were included and AlCl 3 was administered orally at a dose level of 100 mg/kg of body weight per day for 6 weeks; Group IV: animals of this group (10 rats) were given a combination of AlCl 3 and grapefruit juice per day for 6 weeks. At the end of the sixth week, the liver was processed for histological and ultrastructure studies. In addition, ALT and AST were determined in blood sera. The results showed that AlCl 3 induced several histological alterations in the liver, including congestion of blood vessels, leucocytic infiltration, cytoplasmic vacuolation of hepatocytes and fatty infiltrations. Ultrastructural changes include the degeneration of mitochondria, RER swelling and pyknosis of the nuclei with an increase in fat droplets and lysosomes. The biochemical results showed an increase in ALT and AST activities in the AlCl 3 group. However, the group of rats treated with AlCl 3 and grapefruit juice improved the histological and ultrastructural changes, while the levels of ALT and AST were reduced. It was concluded in the results that grapefruit juice has a protective effect against hepatotoxicity of AlCl 3 that can be attributed to the antioxidant properties of its components.

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Hepatoprotective and Antioxidant Potential of Organic and Conventional Grape Juices in Rats Fed a High-Fat Diet

Cited by 28 publications

References 60 publications

Pharmacological evaluation of <i>Vernonia elaeagnifolia</i> (Asteraceae) leaves in hyperlipidemic albino rabbits

Pharmacological evaluation of <i>Vernonia elaeagnifolia</i> (Asteraceae) leaves in hyperlipidemic albino rabbits

Effect of Chronic Treatment with Grape Juice during Pregnancy and Nursing in Central Nervous System of Female Wistar Rats

Effect of Grapefruit Juice on Aluminum-Induced Hepatotoxicity in Albino Rats: Histological, Ultrastructural and Histochemical Assessment

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