The heightened sensitivity of hypophyseal cells of neonatal rats to corticosteroids

Gudoshnikov, V. I.; Fedotov, V. P.

doi:10.1007/bf01189104

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Really, in some cases such sensitivity was even higher than in cultures of more mature animals. 17,18 On the basis of these data we have concluded that GC, together with some other hormonal bioregulators can indeed participate as mediators in programming/imprinting phenomena during perinatal period of ontogeny.…”

Section: Historical and Some Other Aspects Of Dohad Conceptmentioning

confidence: 84%

Translational and some other aspects of DOHaD concept: a polemic overview related to endocrinology and public health

VI¹

2023

EMIJ

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This mini-review describes translational, historical and some other aspects of the concept of developmental origins of health and disease (DOHaD), as well as the connection between development and aging as a challenge to DOHaD paradigm. The main focus is made on endocrine and metabolic mechanisms studied by means of experimental models of laboratory animals and cell cultures and on epidemiological indices of morbidity and mortality in human populations. It is concluded that future investigations should be directed to enforcing the links between biomedical and public health implications of research in DOHaD area.

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Section: Historical and Some Other Aspects Of Dohad Conceptmentioning

confidence: 84%

Translational and some other aspects of DOHaD concept: a polemic overview related to endocrinology and public health

VI¹

2023

EMIJ

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“…The involvement of the author in this important topic began already during the decade of nineties in the last century, when it was possible to observe greater inhibition of DNA and total protein biosynthetic rates by dexamethasone in pituitary cell cultures of neonatal rats, as compared to prepubertal and adult animals. [28] Thereafter it became possible to show sustained retardation of body and organ growth by dexamethasone administered to neonatal rats. [29] Later on, we compared the effects of glucocorticoids and some PNT drugs on body and organ growth in rats.…”

Section: Enhanced Vulnerability Of Developing Mammals To Drugs and Enmentioning

confidence: 99%

The necessity of regional DOHaD centers based on programming/imprinting and embedding-like phenomena

Goudochnikov

2019

Adv Health And Behavior

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A mini-review is presented for the evidence of growth-inhibitory effects of several psychoneurotropic drugs and glucocorticoids on developing animals and humans, together with our own data obtained in experimental models, as well as in epidemiologic studies confirming female predominance in morbidity caused by affective disorders and in consumption of some psychoneurotropic drugs. The emerging concepts of pharmacotoxicologic programming/imprinting and embedding are discussed, justifying the necessity of regional DOHaD centers.

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Role of hormones in perinatal and early postnatal development: Possible contribution to programming/imprinting phenomena

VI¹

2015

Russ J Dev Biol

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The heightened sensitivity of hypophyseal cells of neonatal rats to corticosteroids

Cited by 3 publications

References 11 publications

Translational and some other aspects of DOHaD concept: a polemic overview related to endocrinology and public health

Translational and some other aspects of DOHaD concept: a polemic overview related to endocrinology and public health

The necessity of regional DOHaD centers based on programming/imprinting and embedding-like phenomena

Role of hormones in perinatal and early postnatal development: Possible contribution to programming/imprinting phenomena

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