The necessity of regional DOHaD centers based on programming/imprinting and embedding-like phenomena

Abstract

A mini-review is presented for the evidence of growth-inhibitory effects of several psychoneurotropic drugs and glucocorticoids on developing animals and humans, together with our own data obtained in experimental models, as well as in epidemiologic studies confirming female predominance in morbidity caused by affective disorders and in consumption of some psychoneurotropic drugs. The emerging concepts of pharmacotoxicologic programming/imprinting and embedding are discussed, justifying the necessity of regional DOHaD centers.

Translational and some other aspects of DOHaD concept: a polemic overview related to endocrinology and public health

“…14 However, as a matter of fact, Swedish biochemist Jan Ake Gustafsson was the first to employ the term "programming" already in 1972-1974, as referred to organizational effects of sex steroid hormones in rats. 15 Moreover, it was affirmed that before David Barker, German researcher Gunter Dorner has performed a series of studies on sexual differentiation of the brain in a mode, quite close to DOHaD paradigm. Nevertheless, only after the continuous investigations of David Barker and his colleagues and followers, the DOHaD concept was rather firmly established in a world-wide mode.…”

Environmental Pollution: Considerations from the Onto and Phylopathogenic Models

“…In conclusion, the research in the framework of Developmental Origins of Health and Disease (DOHaD) should be supported by organization of regional DOHaD centers, due to their extremely important role also for environmental area and agriculture [10]. In these centers health professionals could interact with other specialists inside the great paradigm of Public and Collective Health.…”