Previously the opinion has been formed about significant relationship between stress and various diseases including cardiovascular disorders. However, the advances in biomedical science during the last decades provoke the necessity of updating this opinion. Therefore, this work aimed at presentation of bibliographic data that confirm the important role of stress in the etiopathogeny of arterial hypertension and other cardiovascular diseases.
This mini-review describes translational, historical and some other aspects of the concept of developmental origins of health and disease (DOHaD), as well as the connection between development and aging as a challenge to DOHaD paradigm. The main focus is made on endocrine and metabolic mechanisms studied by means of experimental models of laboratory animals and cell cultures and on epidemiological indices of morbidity and mortality in human populations. It is concluded that future investigations should be directed to enforcing the links between biomedical and public health implications of research in DOHaD area.
This short communication describes possible implications of environmental pollution for the onto- and phylopatogenic models that describe etiopathogenic processes along the whole ontogeny and in transgenerational mode respectively.
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