The Healing of Rat Skin Wounds

Levenson, Stanley Μ.; Geever, Erving F.; Crowley, Leo V.; Oates, James F.; Berard, Costan W.; Rosen, Harvey M.

doi:10.1097/00000658-196502000-00019

Cited by 411 publications

(210 citation statements)

References 7 publications

Supporting

Mentioning

196

Contrasting

Unclassified

Order By: Relevance

“…Similar observations in healing tissue have been reported in buffalo calves 19,21 . Levenson et al 24 also demonstrated that elastin plays no detectable role in wound healing.…”

Section: Discussionmentioning

confidence: 99%

Acellular dermal graft for repair of abdominal wall defects in rabbits

Gangwar¹,

Sharma²,

Kumar³

et al. 2006

J. S. Afr. Vet. Assoc.

View full text Add to dashboard Cite

Sixteen clinically healthy New Zealand white rabbits of either sex were divided into 2 equal groups (I and II) of 8 animals each. Under thiopental sodium (2.5 %) anaesthesia a 2 Ã— 3 cm full-thickness abdominal wall defect in the mid-ventral abdominal wall was created and repaired with an acellular dermal graft (ADG) in all the animals of group I (test group). In animals of group II (control group) a full-thickness linear midline abdominal muscular wall incision was made and repaired with a continuous suture pattern using 2-0 nylon

show abstract

“…Similar observations in healing tissue have been reported in buffalo calves 19,21 . Levenson et al 24 also demonstrated that elastin plays no detectable role in wound healing.…”

Section: Discussionmentioning

confidence: 99%

Acellular dermal graft for repair of abdominal wall defects in rabbits

Gangwar¹,

Sharma²,

Kumar³

et al. 2006

J. S. Afr. Vet. Assoc.

View full text Add to dashboard Cite

show abstract

“…Furthermore, the originally disorganized collagen fibers become rearranged, cross-linked, and aligned along tension lines. this process is carried out by matrix metalloproteinases (MMps) which are secreted by fibroblasts, macrophages and endothelial cells (41). MMPs are endopeptidases and play an important role not only in wound healing, but also in other physiological and pathological processes such as morphogenesis, angiogenesis, tissue repair, cirrhosis, arthritis and metastasis (42).…”

Section: Principles Of Wound Healingmentioning

confidence: 99%

Radiotherapy and wound healing: Principles, management and prospects (Review)

Gieringer

Gosepath²,

Naim³

2011

Oncol Rep

View full text Add to dashboard Cite

Abstract. radiation therapy is a major therapeutic modality in the management of cancer patients. Over 60% of these patients receive radiotherapy at some point during their course of treatment and over 90% will develop skin reactions after therapy. problematic wound healing in radiation-damaged tissue constitutes a major surgical difficulty and despite all efforts, irradiated skin remains a therapeutic challenge. this review provides an overview of the fundamental principles of radiation therapy with regards to the wound healing in normal and irradiated skin. Furthermore, it presents techniques that describe how to prevent and manage skin side effects as well as prospects that may improve cutaneous wound repair in general and in irradiated skin.

show abstract

“…G-CSF may accelerate several cascades of events such as chemotaxis, phagocytosis, and oxidative burst, which take place in wound healing. Levenson et al (1965) have suggested a significant strong correlation between tensile strength of wound and its hydroxyproline content. Jyung et al (1994) demonstrated positive effects of GM-CSF and G-CSF on wound healing.…”

Section: Discussionmentioning

confidence: 99%

Effects of Granulocyte-Colony Stimulating Factor on Wound Healing in a Mouse Model of Burn Trauma

Eroğlu

Agalar

Altuntaş

et al. 2004

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

The effects of burn trauma and granulocyte-colony stimulating factor (G-CSF) treatment on wound healing in a surgical incision model were studied. Sixty adult male mice were used in this study. Under general anesthesia hot water at 97°C was applied for 3 sec to the dorsum of the mice in order to achieve 20% burn wound. After burn trauma, full thickness midline skin incision 2 cm in length was performed on the abdominal wall and then were sutured primarily with 4/0 polypropylene. In Group I only skin incision was performed, group II had skin incision and burn, in group III G-CSF (0.03 BU/30 g) was applied intraperitoneally after burn and skin incision. Breaking strength and 5-hydroxyproline (5-HP) levels of the wounds were calculated 5 and 10 days after the procedure. 5-HP levels and breaking strength values showed statistical difference between groups II-III and I-II (p<0.05). 5-HP levels were lowest in incision and burn group (41.80 μ g/mg). Breaking strength levels were also lowest in the same group (0.12 kg) (p<0.05). These results suggest that third degree burn causes a significant impairment on incisional wound healing and G-CSF ameliorates this impairment.burn; wound; wound healing; G-CSF

show abstract

The Healing of Rat Skin Wounds

Cited by 411 publications

References 7 publications

Acellular dermal graft for repair of abdominal wall defects in rabbits

Acellular dermal graft for repair of abdominal wall defects in rabbits

Radiotherapy and wound healing: Principles, management and prospects (Review)

Effects of Granulocyte-Colony Stimulating Factor on Wound Healing in a Mouse Model of Burn Trauma

Contact Info

Product

Resources

About