The haemocompatibility of polyurethane–hyaluronic acid copolymers

Polyurethane/Dermatan Sulfate Copolymers as Hemocompatible, Non‐Biofouling Materials

“…[22] A 10% (w/v) solution of methylene di( p-phenyl isocyanate) (MDI; 4 mmol; MW ¼ 250 g Á mol À1 ) in 10 mL of anhydrous DMF was prepared in a 100 mL round-bottom flask and stirred at room temperature. A 10% (w/v) solution of poly(tetramethylene oxide) (PTMO; 2 mmol; MW ¼ 1 000 g Á mol À1 ) in 20 mL of anhydrous DMF was added, and the mixture was heated to 90 8C and held there for 3 h under argon.…”

“…Surface energy parameters were calculated using the model described by Good and van Oss et al [31] and our previous work. [22] Topography and Roughness Surface topography and roughness of PU and PU/DS films were evaluated using a scanning white light interferometer (Zygo NewView 6300 Optical Profiler, Zygo Corp., Middlefield, CT). Polymer samples were cast on glass coverslips as described in the film-casting section, and then analyzed by means of the interferometer using a 10Â interferometric objective, 1Â field zoom lens, 20 mm scan length, and <0.1 nm vertical resolution.…”

“…In being both hydrophilic and anionic in nature, the glycocalyx intrinsically possesses two physical properties that are often the goal when generating synthetic non-thrombogenic or non-fouling materials. [1,3,4] The surfaces of various polymers and metals have been modified with polysaccharides such as hyaluronic acid (HA), [18][19][20]22] dextran, [16] alginate, [19] and chitosan [23] in order to decrease non-specific biomolecule binding. However, the search continues for improved non-adhesive materials, as most efforts to date have either not achieved sufficient prevention of fouling or cannot be modified to conform to the needs of certain applications.…”

Atividade antioxidante do ácido hialurônico extraído da crista de frango

“…O AH é usado no tratamento de doenças degenerativas e inflamatórias das articulações dos ossos, na reposição do fluído sinovial e na liberação de agentes quimioterápicos em implantes cirúrgicos, como meio hidratante e como sistema para encapsulação e liberação controlada de fármacos e cosméticos (OGRODOWSKI, 2006). Ele também é aplicado em lentes de contato (Beek et al, 2008) e em aplicações vasculares, como um copolímero com propriedades antitrombóticas (XU et al, 2008).…”

Purification and characterization of hyaluronic acid from chicken combs

“…Studies have shown that the hyaluronic acid is not only a lubricant with dermatologic and ophthalmologic applications but also can be used in a control system for drug release, as in anesthesia prolongation in bones and joints (GOLDENHEIN et al, 2001), arthropathy treatment (SUZUKI et al, 2001), chemotherapeutic agents in surgical implants (AEBISCHER et al, 2001), drug release in dental caries (SUHONEN & SCHUG, 2000), controlled antigen release for immunotherapy (PARDOLL et al, 2001), and contact lenses (BEEK et al, 2008), and as a copolymer with anti-thrombotic properties in vascular applications (XU et al, 2008).…”