The growing merits and dwindling limitations of bacterial cellulose-based tissue engineering scaffolds

Roman, Maren; Haring, Alexander P.; Bertucio, Timothy J

doi:10.1016/j.coche.2019.03.006

Cited by 54 publications

(54 citation statements)

References 118 publications

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“…Natural polymers (chitosan, collagen, cellulose) offer several advantages, because of their biocompatibility, hydrophilicity and biodegradability (Daugela et al 2018). Ideally, a tissue engineering scaffold degrades in the site of implantation at a rate corresponding with the rate of tissue regeneration and promotes non-toxic degradation products that are either metabolized or eliminated from the body (Roman et al 2019). Generally, the in vivo degradation of biomaterials can occur through thermal, mechanical, chemical, or enzymatic processes (Roman et al 2019).…”

Section: Hard Tissue Engineeringmentioning

confidence: 99%

“…Although BC will occupy the space intended for the bone tissue, it can provide constant structural support (Hickey and Pelling 2019). On the contrary, the relative stability of BC confers ease of sterilization with heat, steam, ethylene oxide gas, or radiation; a long shelf life of the sterile material and prolonged structural integrity upon implantation (Roman et al 2019). A biologically inert material is desired to eliminate foreign body responses (Oliveira Barud et al 2015).…”

Section: Hard Tissue Engineeringmentioning

confidence: 99%

“…Bioactivity is the ability of materials to promote attachment of cells and proliferation on the scaffold (Roman et al 2019). Therefore, proper bioactivity is a key requirement to obtain certain responses (Hickey and Pelling 2019).…”

Section: Hard Tissue Engineeringmentioning

confidence: 99%

“…However, its osteogenic, osteoinductive and osteoconductive properties depend on the chemical composition of the used composite material (Daugela et al 2018;Kargozar et al 2019). In addition, a the balance between biodegradability and other scaffold properties (mechanical, chemical and structural) need to be optimized for individual applications (Roman et al 2019).…”

Section: Hard Tissue Engineeringmentioning

confidence: 99%

“…Pore size has to be adequate for cell adhesion, proliferation, migration, differentiation and nutrient diffusion (Rajwade et al 2015). Different pore sizes are required for cell migration and neovascularization (Roman et al 2019). The water content of the extracellular matrix ranges from 60% in fibrous tissues, like tendons, to about 80% in healthy articular cartilage.…”

Section: Fibrocartilaginous Tissue Engineeringmentioning

confidence: 99%

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Applications of bacterial-synthesized cellulose in veterinary medicine – a review

et al. 2019

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Tissue engineering promotes tissue regeneration through biomaterials that have excellent properties and have the potential to replace tissues. Many studies show that bacterial cellulose (BC) might ensure tissue regeneration and substitution, being used for the bioengineering of hard, cartilaginous and soft tissues. Bacterial cellulose is extensively used as wound dressing material and results show that BC is a promising tissue scaffold (bone, cardiovascular, urinary tissue). It can be combined with polymeric and non-polymeric compounds to acquire antimicrobial, cell-adhesion and proliferation properties. To ensure proper tissue regeneration, the material has to be: biocompatible, with minimum tissue reaction and biodegradability; bio-absorbable, to promote tissue development, cellular interaction and grow; resistant to support the weight of the newly formed tissue. Its versatile structure, physical and biochemical properties can be adjusted by adapting the bacteria culturing conditions. The main biomedical applications seem to be as hard (bone, dental), fibrocartilaginous (meniscal) and soft tissue (skin, cardiovascular, urinary) substituents. This paper reviews the current state of knowledge, challenges and future applications of BC and its biomedical potential in veterinary medicine. It was focused on the main uses in regeneration and scaffold tissue replacement and, although BC showed promising results, there is a lack of successful results of BC use in clinical practice. Most studies were performed only at experimental level and further research is needed for BC to enter clinical veterinary practice.

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Section: Hard Tissue Engineeringmentioning

confidence: 99%

Section: Hard Tissue Engineeringmentioning

confidence: 99%

Section: Hard Tissue Engineeringmentioning

confidence: 99%

Section: Hard Tissue Engineeringmentioning

confidence: 99%

Section: Fibrocartilaginous Tissue Engineeringmentioning

confidence: 99%

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Applications of bacterial-synthesized cellulose in veterinary medicine – a review

et al. 2019

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Development of novel biocomposites based on the clean production of microbial cellulose from dairy waste (sour whey)

Nguyen

Ngwabebhoh

Saha

et al. 2021

J of Applied Polymer Sci

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This work explores the production of kombucha‐derived bacterial cellulose (KBC) from sour whey via the fermentation method using Komagatacibacter xylinus. The biosynthesis process was optimized by design of experiments and the results displayed highest KBC yield at 1000 ml/L sour whey waste, 87.39 g/L cane sugar, 6 g/L black tea, and 78.91 ml/L bacteria volume under 21 days culture period at 30°C. Optimum fermentation batch efficiency was achieved in large scale with cultured medium depths of 0.5 cm and low‐residual bacteria suspension volume of 72.31 ± 8.74 ml. The obtained KBC membranes were analyzed by SEM, FTIR, XRD, and TGA. The obtained results show no significant differences for all prepared KBC samples when compared to pristine bacterial cellulose from standard Hestrin and Schramm (HS) medium. In addition, the optimized KBC was investigated as a suitable bio‐filler in the preparation of biocomposite materials. The prepared biocomposites as leather alternative were further characterized and their mechanical tensile strength and elongation at break determined in the range of 135.61 ± 9.15 to 154.89 ± 9.09 N/mm2 and 31.06 ± 0.32 to 92.33 ± 6.91%, respectively. This model obtained depicts high‐yield production of KBC and its potential in the preparation of biocomposites.

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Modification of microstructure and selected physicochemical properties of bacterial cellulose produced by bacterial isolate using hydrocolloid‐fortified Hestrin–Schramm medium

Nguyen

Tran

Nguyen

et al. 2023

Biotechnology Progress

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Bacterial cellulose (BC) is a biopolymer with applications in numerous industries such as food and pharmaceutical sectors. In this study, various hydrocolloids including modified starches (oxidized starch—1404 and hydroxypropyl starch—1440), locust bean gum, xanthan gum (XG), guar gum, and carboxymethyl cellulose were added to the Hestrin‐Schramm medium to improve the production performance and microstructure of BC by Gluconacetobacter entanii isolated from coconut water. After 14‐day fermentation, medium supplemented with 0.1% carboxymethyl cellulose and 0.1% XG resulted in the highest BC yield with dry BC content of 9.82 and 6.06 g/L, respectively. In addition, scanning electron microscopy showed that all modified films have the characteristic three‐dimensional network of cellulose nanofibers with dense structure and low porosity as well as larger fiber size compared to control. X‐ray diffraction indicated that BC fortified with carboxymethyl cellulose exhibited lower crystallinity while Fourier infrared spectroscopy showed characteristic peaks of both control and modified BC films.

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The growing merits and dwindling limitations of bacterial cellulose-based tissue engineering scaffolds

Cited by 54 publications

References 118 publications

Applications of bacterial-synthesized cellulose in veterinary medicine – a review

Applications of bacterial-synthesized cellulose in veterinary medicine – a review

Development of novel biocomposites based on the clean production of microbial cellulose from dairy waste (sour whey)

Modification of microstructure and selected physicochemical properties of bacterial cellulose produced by bacterial isolate using hydrocolloid‐fortified Hestrin–Schramm medium

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