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Traditional wound care methods include wound infection control, adequate nutritional supplements, education of changing position every 2-3 h to avoid tissue hypoxia, vacuum assistant closure, debridement, skin graft, and tissue flap. Electric current stimulation, ultrasound, laser, and hydrotherapy have emerged as adjuvant therapies. However, most, if not all, of these therapies are expensive, and the treatment results are variable. The development of the active methods to improve wound healing is mandatory. CO administration has been known to improve microcirculation and local oxygen supply that are beneficial to wound healing. Here, the metal ion-ligand coordination nanoarchitecture was designed to reveal NIR light-induced CO generation for wound healing. The administration simply topically dropped the colloidal solution on the incisional wound, followed by exposure of near-infrared (NIR) lamp to yield CO, resulting in the observation of the accelerated wound healing.

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Objective: Cell migration is an essential process in skin wound healing. Photodynamic therapy (PDT) enhances wound healing by photoactivating a photosensitizer with a specific wavelength of light. Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel expressed in multiple layers of keratinocytes. Recent studies showed that the activation of CFTR-related downstream signaling affects skin wound healing. We examined whether indocyanine green (ICG)-mediated PDT-enhanced cell migration is related to CFTR activation. Approach: The spatial and temporal expression levels of CFTR and proteins involved in focal adhesion, including focal adhesion kinase (FAK) and paxillin, were evaluated during cell migration in vitro and in vivo for wound healing. Results: ICG-PDT-conditioned medium collected from cells exposed to 5 J/cm 2 near-infrared light in the presence of 100 lg/mL ICG activated CFTR and enhanced HaCaT cell migration. The expression of phosphorylated FAK Tyr861 and phosphorylated paxillin in focal adhesions was spatially and temporally regulated in parallel by ICG-PDT-conditioned medium. Curcumin, a nonspecific activator of CFTR, further increased PDT-enhanced cell migration, whereas inhibition of CFTR and FAK delayed cell migration. The involvement of CFTR in ICG-PDTenhanced skin wound healing was confirmed in a mouse back skin wound model. Innovation: CFTR is a potential new therapeutic target in ICG-PDT to enhance wound healing. Conclusion: ICG-PDT-enhanced cell migration may be related to activation of the CFTR and FAK pathway. Conditioned medium collected from ICG-PDT may be useful for treating patients with chronic skin ulcer by regulating CFTR expression in keratinocytes.

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Nowadays, the advancement of thermoconductive electromagnetic interference (EMI) shielding materials for the next generation of electronics is in high demand. We present, in this research, the fabrication of the highly thermoconductive nanopapers based on aramid nanofiber (ANF) and ultralong copper nanowires (ULCuNWs) with outstanding EMI shielding effectiveness (SE) and mechanical properties. A homogeneous red brick color nanopaper (thickness 40–50 μm) was fabricated by homogenizing a mixture of the ULCuNWs (10–40 wt %) in the ANF suspension, then vacuum filtration, and drying. The morphology of the nanopapers reveals that the ULCuNWs were uniformly dispersed and interweaved with ANF to form two-dimensional (2D) layers in the nanopapers. With the increase in the ULCuNWs content, the nanopaper shows outstanding mechanical properties and reaches the optimal tensile strength (σ) of 228 MPa and Young’s modulus of 6.12 GPa at the filler content of 30 wt %. Moreover, the variation of the in-plane thermal conductivity (λ//) and EMI SE of the nanopapers strongly depends on the amount of the ULCuNWs; the ULCuNWs30/ANF nanopapers obtain a notable λ// and EMI SE of around 8.25 W·m–1·K1 and 54.7 dB, respectively, with the mass content of 30 wt % at ambient conditions. The thermal treatment of the ULCuNWs30/ANF nanopapers at 180 °C increases the λ// and EMI SE by 60% and 9%, respectively. The ULCuNWs30/ANF nanopaper demonstrates an impressive heat dissipating capability. In addition, the ULCuNWs/ANF nanopapers show eminent thermal stability up to 500 °C and flame retardancy with an extremely low total heat release of 0.72 kJ·g–1. Therefore, ULCuNWs/ANF nanopapers can be considered great potential materials alternative to the current thermoconductive materials for heat dissipating applications in modern electronics.