The Green Anti-Cancer Weapon. The Role of Natural Compounds in Bladder Cancer Treatment

Abstract

Bladder cancer (BC) is the second most common genitourinary cancer. In 2018, 550,000 people in the world were diagnosed with BC, and the number of new cases continues to rise. BC is also characterized by high recurrence risk, despite therapies. Although in the last few years, the range of BC therapy has considerably widened, it is associated with severe side effects and the development of drug resistance, which is hampering treatment success. Thus, patients are increasingly choosing products of natural origin as an alternative or complementary therapeutic options. Therefore, in this article, we aim to elucidate, using the available literature, the role of natural substances such as curcumin, sulforaphane, resveratrol, quercetin, 6-gingerol, delphinidin, epigallocatechin-3-gallate and gossypol in the BC treatment. Numerous clinical and preclinical studies point to their role in the modulation of the signaling pathways, such as cell proliferation, cell survival, apoptosis and cell death.

Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives

“…Bladder cancer is the second most prevalent type of cancer, and its advancement is mainly linked to the development of spontaneous metastases, which further aggravate the disease [ 104 ]. The disease is a severe problem, and despite great medical discoveries over the last 15 years, the death rate from bladder cancer has only decreased by 5% [ 105 ].…”

The emerging roles of exosomal long non‐coding RNAs in bladder cancer

“…Due to its very aggressive nature, BC has the lower survival rate of urology cancers. [126][127][128] This extremely high mortality rate is primarily the result of its early asymptomatic development, so it is diagnosed as late. 129,130 Therefore, there is an urgent need for new diagnostic tools and new treatment strategies.…”

Brokkoli Va Brokkoli Nihollaridan Turli Kasalliklarning Oldini Olish Va Davolashda Foydalanish

“…Ингибирование канцерогенеза клеток мочевого пузыря экстрактом брокколи было связано с повышенной индукцией глутатион-S-трансферазы (GST) и NAD(P)H:хиноноксидоредуктазы 1 (NQO1), которые являются важными защитными ферментами от окислителей и канцерогенов. GST являются важными ферментами фазы II, которые обычно детоксифицируют канцерогенные метаболиты с участием конъюгата многих электрофильных субстратов с глутатионом.исследования in vitro показали, что изотиоцианатный экстракт проростков брокколи индуцирует митохондриальноопосредованный апоптоз, а также останавливает клетки в Sи M-фазах [17].…”

“…Brokkoli ekstrakti bilan siydik pufagi hujayralari karsinogenezini bloklovchi oksidlovchilar va kanserogenlarga qarshi muhim himoya fermenti bo'lgan glutation-S-transferaza (GST) va NAD(P)H:xinon oksidoreduktaza 1 (NQO1) induktsiyasining kuchayishi bilan bog'liq. GSTlar, odatda, glutation bilan koʻplab elektrofil substratlar konyugati ishtirok etgan kanserogen metabolitlarni zararsizlantiruvchi muhim II faza fermenti in vitro tadqiqotlar shuni koʻrsatdiki, brokkoli nihollari ekstrakti mitoxondriya vositachiligida apoptozni qoʻzgʻatadi, shuningdek, S-va M-fazalardagi hujayralarni toʻxtatadi [17].…”