The Global Burden of Osteoporosis, Low Bone Mass, and Its Related Fracture in 204 Countries and Territories, 1990-2019

Shen, Yuyan; Huang, Xin; Wu, JunYun; Lin, Xiling; Zhou, Xiao; Zhu, Zhaowu; Pan, Xiaowen; Xu, Jingya; Qiao, Jie; Zhang, Tianyue; Ye, Linxia; Jiang, Hongwei; Ren, Yong; Shan, Peng-Fei

doi:10.3389/fendo.2022.882241

Cited by 90 publications

(43 citation statements)

References 53 publications

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“…We found that the postoperative residual back pain 6 months after PKP was more obvious in OVCF patients aged ≥60 years than in patients aged <60 years. There might be the following reasons: (a) the degree of osteoporosis was more serious in the elderly ( 16 ); (b) the elderly had poor tolerance to surgical trauma and thus had slow postoperative recovery, long hospital stay and high risk of postoperative complications ( 17 ). This result was consistent with Yimin et al who suggested that younger age was favorable factor for the prognosis of PKP ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

A novel scoring system to predict the residual back pain after percutaneous kyphoplasty for osteoporotic vertebral compression fracture

et al. 2022

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ObjectiveTo establish a scoring system to predict the residual back pain after percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fracture (OVCF).Materials and methodsWe retrospectively reviewed the clinical records of 98 patients who were diagnosed of single-vertebral OVCF and underwent PKP surgery in our department from January 2015 to December 2017. The following clinical characteristics including age, gender, disease course, fracture location, fracture type, segmental kyphosis, and bone cement volume were all recorded, and the effects of these factors on postoperative pain (at 1-month and 6-month postoperative) were also analyzed respectively. Based on 6-month postoperative VAS score, the included patients were divided into two groups, namely the residual back pain group (19 patients) and the non-residual back pain group (79 patients). The independent risk factors of residual back pain after PKP were screened and the scoring system was established by the multivariate logistic regression analysis. The performance of this scoring system was also prospectively validated using the clinical data of 45 patients with single-vertebral OVCF from January 2018 to December 2019.ResultsThe scoring system was consist of five clinical characteristics which were confirmed as significant predictors of residual back pain after PKP, namely, age ≥60 years (P = 0.021), fracture location = thoracic or lumbar (P = 0.002), fracture type = OF4 type (P = 0.018), segmental kyphosis ≥20° (P = 0.014), and bone cement volume <5 ml (P = 0.001). Patients in the residual back pain group showed a significant higher score than the non-residual back pain group (6.84 ± 1.71 vs. 2.66 ± 1.97, t = 8.499, P < 0.001), and the optimal cut-off value for the scoring system was 5 points. The sensitivity and specificity of the scoring system for predicting residual back pain after PKP were 84.21% and 87.34%, respectively, in derivation set and 78.57% and 83.87% in validation set.ConclusionThis novel scoring system showed satisfactory diagnostic efficacy in predicting residual back pain after PKP for single-vertebral OVCF. Patients with the score of 5–9 had a high risk of postoperative residual back pain, while the patients with score of 0–4 was low.

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Section: Discussionmentioning

confidence: 99%

A novel scoring system to predict the residual back pain after percutaneous kyphoplasty for osteoporotic vertebral compression fracture

et al. 2022

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“…The mean (S.E.) BMD values of participants were 0.91 (0.01) g/cm 2 for the lumbar spine L1, 0.99 (0.01) g/cm 2 for the L2, 1.05 (0.01) g/cm 2 for the L3, 1.05 (0.01) g/cm 2 for the L4, 0.64 (0.00) g/cm 2 for the greater trochanter, and 0.88 (0.01) g/cm 2 for the total hip.…”

Section: Characteristics Of Participantsmentioning

confidence: 98%

“…Osteoporosis is a systemic skeletal disease characterized by increased bone fragility and fracture susceptibility due to low bone mass and degeneration of bone tissue microarchitecture [ 1 ]. Osteoporosis contributes a significant disease burden globally, with the number of deaths and disability-adjusted life-years due to low bone mineral density (BMD) increasing globally from 207,367 and 8,588,936 in 1990 to 437,884 and 16,647,466 in 2019 [ 2 ]. Differences in the incidence and prevalence of osteoporosis worldwide are difficult to determine due to underdiagnosis [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Differences in the prevalence and risk factors of osteoporosis in chinese urban and rural regions: a cross-sectional study

Zheng

Wan

Liu

et al. 2023

BMC Musculoskelet Disord

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Background Bone mineral density (BMD) and prevalence of osteoporosis may differ between urban and rural populations. This study aimed to investigate the differences in BMD characteristics between urban and rural populations in Jiangsu, China. Methods A total of 2,711 participants aged 20 years and older were included in the cross-sectional study. Multistage and stratified cluster random sampling was used as the sampling strategy. BMD was measured by the method of dual-energy x-ray absorptiometry (DXA). Data were collected through questionnaires/interview. BMD values at the lumbar spine (L1-L4), femoral neck, total hip, and greater trochanter were collected. Descriptive statistics were used to demonstrate the characteristics of urban and rural participants. Multivariate logistic regression analysis was utilized to analyze the factors that may be associated with osteoporosis in urban and rural populations. Results Of these participants, 1,540 (50.49%) were females and 1,363 (42.14%) were from urban. The prevalence of osteoporosis in urban and rural populations was 5.52% and 10.33%, respectively. In terms of gender, the prevalence of osteoporosis was 2.68% in males and 13.82% in females. For menopausal status, the prevalence of osteoporosis was 30.34% in postmenopausal females and 4.78% in premenopausal females. In urban populations, older age [adjusted odds ratio (AOR) = 2.36, 95%CI, 2.35–2.36), hypertension (AOR = 1.37, 95%CI, 1.36–1.37), unmarried (AOR = 4.04, 95%CI, 3.99–4.09), smoking everyday (AOR = 2.26, 95%CI, 2.23–2.28), family history of osteoporosis (AOR = 1.66, 95%CI, 1.65–1.67), dyslipidemia (AOR = 1.05, 95%CI, 1.04–1.05), and higher β-crosslaps (β-CTX) level (AOR = 1.02, 95%CI, 1.02–1.02) were associated with an increased risk of osteoporosis, while males (AOR = 0.04, 95%CI, 0.04–0.04), higher education level (AOR = 0.95, 95%CI, 0.95–0.95), and aquatic product intake (AOR = 0.99, 95%CI, 0.99–0.99) were related to decreased risk of osteoporosis. Similar results were also observed in rural populations, and (all P < 0.05). Conclusion The prevalence of osteoporosis in rural populations was higher than that in urban populations, and the factors associated with the risk of osteoporosis were similar in urban and rural populations.

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“…However, secondary osteoporosis, such as alcoholic osteoporosis, is more common in men (Patsch et al, 2011;Pasco et al, 2021). The dangers of osteoporosis are not just the symptoms, but also the complications it creates (Li et al, 2022;Shen et al, 2022;Wang and Xiao, 2022). Researchers generally evaluate the development of osteoporosis by measuring bone mineral density at the lumbar spine (Genest et al, 2021), but this is a physical test to detect bone health.…”

Section: Introductionmentioning

confidence: 99%

Higher serum apolipoprotein B level will reduce the bone mineral density and increase the risk of osteopenia or osteoporosis in adults

Zhu

Zhao-fu³

et al. 2022

Front. Cell Dev. Biol.

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Objective: There is very limited evidence in the NHANES database linking serum apolipoprotein B and lumbar bone mineral density (BMD) in adults aged 20–59 years. There are few studies associating apolipoprotein B concentrations with BMD, and there is some debate about the association between obesity and BMD. Therefore, the purpose of this study was to determine the association between serum apolipoprotein B concentrations and lumbar spine BMD in adults aged 20–59 years and to predict its association with risk of osteopenia or osteoporosis.Methods: A cross-sectional study of the entire US ambulatory population was conducted using data from the National Health and Nutrition Examination Survey (NHANES) database. Weighted multiple regression equation models were used to assess the association between serum apolipoprotein B and lumbar BMD. A logistic weighted regression model was used to assess the association between serum apolipoprotein B concentrations and risk of osteopenia or osteoporosis. Subsequent stratified analyses were performed to refine the primary population of association.Results: Our study showed a significant negative association between serum apolipoprotein B concentration and lumbar BMD and a significant positive association with the risk of osteoporosis or osteopenia in the total population. After stratifying by sex, age and race, we concluded differently. The association of serum apolipoprotein B concentration with lumbar spine BMD and risk of osteopenia or osteoporosis was significant in male, but not in female. After stratification by age, the negative association between serum apolipoprotein B concentrations and lumbar BMD and the positive association with risk of osteopenia or osteoporosis was more significant in the 30–39 and 50–59 years age groups. When stratified by race, serum apolipoprotein B concentrations were significantly negatively associated with lumbar BMD and positively associated with risk of osteopenia or osteoporosis in Mexican American and non-Hispanic black populations. Thus, these findings suggest that these associations are influenced by sex, age, and race, respectively.Conclusion: Our results suggest that the association between serum apolipoprotein B levels and the risk of lumbar BMD and osteopenia or osteoporosis varies by sex, age, and race. In men, elevated serum apolipoprotein B levels were negative for bone quality. Elevated serum apolipoprotein B levels in the age groups 30–39 and 50–59 years also had a negative effect on bone quality. In the Mexican American and Non-Hispanic Black populations, elevated serum apolipoprotein B levels also had a significant negative effect on bone quality.

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The Global Burden of Osteoporosis, Low Bone Mass, and Its Related Fracture in 204 Countries and Territories, 1990-2019

Cited by 90 publications

References 53 publications

A novel scoring system to predict the residual back pain after percutaneous kyphoplasty for osteoporotic vertebral compression fracture

A novel scoring system to predict the residual back pain after percutaneous kyphoplasty for osteoporotic vertebral compression fracture

Differences in the prevalence and risk factors of osteoporosis in chinese urban and rural regions: a cross-sectional study

Higher serum apolipoprotein B level will reduce the bone mineral density and increase the risk of osteopenia or osteoporosis in adults

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