Higher serum apolipoprotein B level will reduce the bone mineral density and increase the risk of osteopenia or osteoporosis in adults

Abstract

Objective: There is very limited evidence in the NHANES database linking serum apolipoprotein B and lumbar bone mineral density (BMD) in adults aged 20–59 years. There are few studies associating apolipoprotein B concentrations with BMD, and there is some debate about the association between obesity and BMD. Therefore, the purpose of this study was to determine the association between serum apolipoprotein B concentrations and lumbar spine BMD in adults aged 20–59 years and to predict its association with risk of osteopenia or osteoporosis.Methods: A cross-sectional study of the entire US ambulatory population was conducted using data from the National Health and Nutrition Examination Survey (NHANES) database. Weighted multiple regression equation models were used to assess the association between serum apolipoprotein B and lumbar BMD. A logistic weighted regression model was used to assess the association between serum apolipoprotein B concentrations and risk of osteopenia or osteoporosis. Subsequent stratified analyses were performed to refine the primary population of association.Results: Our study showed a significant negative association between serum apolipoprotein B concentration and lumbar BMD and a significant positive association with the risk of osteoporosis or osteopenia in the total population. After stratifying by sex, age and race, we concluded differently. The association of serum apolipoprotein B concentration with lumbar spine BMD and risk of osteopenia or osteoporosis was significant in male, but not in female. After stratification by age, the negative association between serum apolipoprotein B concentrations and lumbar BMD and the positive association with risk of osteopenia or osteoporosis was more significant in the 30–39 and 50–59 years age groups. When stratified by race, serum apolipoprotein B concentrations were significantly negatively associated with lumbar BMD and positively associated with risk of osteopenia or osteoporosis in Mexican American and non-Hispanic black populations. Thus, these findings suggest that these associations are influenced by sex, age, and race, respectively.Conclusion: Our results suggest that the association between serum apolipoprotein B levels and the risk of lumbar BMD and osteopenia or osteoporosis varies by sex, age, and race. In men, elevated serum apolipoprotein B levels were negative for bone quality. Elevated serum apolipoprotein B levels in the age groups 30–39 and 50–59 years also had a negative effect on bone quality. In the Mexican American and Non-Hispanic Black populations, elevated serum apolipoprotein B levels also had a significant negative effect on bone quality.

TC and LDL-C are negatively correlated with bone mineral density in patients with osteoporosis

“…However, in a study in Chinese women, the relationship between TC, LDL-C levels, and lumbar spine BMD was found to be nonlinear, with a negative correlation on the left side of the inflection point and an increase in BMD with an increase in TC and LDL-C on the right side [35]. Zhu et al [36] observed a significant negative correlation between Apo-B concentrations in men and lumbar spine bone density; namely, an increase in Am J Transl Res 2024;16(1):163-178…”

Chronic Kidney Disease in Patients with Hip Fracture: Prevalence and Outcomes

“…Both a negative relationship between total cholesterol and low-density lipoprotein cholesterol concentrations and BMD [153][154][155][156][157][158] and a positive association between high-density lipoprotein cholesterol and BMD [159] have been reported. Other studies, however, found that higher serum high-density lipoprotein cholesterol and apolipoprotein B levels (traditionally viewed as a protective for CVD factor) reduced BMD and may increase the risk of osteoporotic fracture (including HF) independently of traditional risk factors for fractures [160][161][162][163][164][165][166]. Tis may possibly occur by reduction of osteoblast numbers [167] or function via rare adverse genetic variants [168].…”

Association between urinary glyphosate exposure and bone mineral density in adults

“…A review of previous studies found that most studies on bone mineral density have focused on people aged 20 to 59 years. [12][13][14] Adolescents are in a critical growth phase, and bones are in the building phase until the age of 20 years. In contrast, people older than 60 years may have more underlying diseases.…”