The genus Anemarrhena Bunge: A review on ethnopharmacology, phytochemistry and pharmacology

Wang, Yingli; Yang, Dan; Yang, Dawei; Hu, Yu-Li; Zhang, Le; Zhang, Chunhong; Zhu, Hong; Cui, Zhan-Hu; Li, Min-Hui; Liu, Yanze

doi:10.1016/j.jep.2014.02.013

Cited by 130 publications

(85 citation statements)

References 65 publications

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“…As a typical herbal medicine, A. asphodeloides frequently used to treat febrile diseases, cough, hematochezia and hemoptysis in clinical practice [1]. Phytochemical studies on A. asphodeloides revealed that it contained steroidal saponins, xanthones, anthraquinones, phenylpropanoids, alkaloids and so on [2]. Furthermore, it has been reported that steroidal saponins are the most important active constituents that contribute to the pharmacological efficacy of A. asphodeloides [3].…”

Section: Introductionmentioning

confidence: 99%

Development and validation of liquid chromatography–tandem mass spectrometry method for simultaneous determination of six steroidal saponins in rat plasma and its application to a pharmacokinetics study

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Development and validation of liquid chromatography–tandem mass spectrometry method for simultaneous determination of six steroidal saponins in rat plasma and its application to a pharmacokinetics study

et al. 2015

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“…Of these ingredients, AA has been used as an antipyretic, antiphlogistic, sedative, and diuretic agent and CC has been used to treat patients who have gastroenteritis and diarrhea in tradition Chinese medicine [8–10]. AA contains saponins such as timosaponin AIII and xanthones such as mangiferin [11].…”

Section: Introductionmentioning

confidence: 99%

The Rhizome Mixture of Anemarrhena asphodeloides and Coptidis chinensis Ameliorates Acute and Chronic Colitis in Mice by Inhibiting the Binding of Lipopolysaccharide to TLR4 and IRAK1 Phosphorylation

Jeong

Jang

Hyam

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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In the previous study, the mixture of the rhizome of Anemarrhena asphodeloides (AA, family Liliaceae) and the rhizome of Coptidis chinensis (CC, family Ranunculaceae) (AC-mix) improved TNBS- or oxazolone-induced colitis in mice. Therefore, to investigate its anticolitic mechanism, we measured its effect in acute and chronic DSS-induced colitic mice and investigated its anti-inflammatory mechanism in peritoneal macrophages. AC-mix potently suppressed DSS-induced body weight loss, colon shortening, myeloperoxidase activity, and TNF-α, IL-1β, and IL-6 expressions in acute or chronic DSS-stimulated colitic mice. Among AC-mix ingredients, AA, CC, and their main constituents mangiferin and berberine potently inhibited the expression of proinflammatory cytokines TNF-α and IL-1β, as well as the activation of NF-κB in LPS-stimulated peritoneal macrophages. AA and mangiferin potently inhibited IRAK phosphorylation, but CC and berberine potently inhibited the binding of LPS to TLR4 on macrophages, as well as the phosphorylation of IRAK1. AC-mix potently inhibited IRAK phosphorylation and LPS binding to TLR4 on macrophages. Based on these findings, AC-mix may ameliorate colitis by the synergistic inhibition of IRAK phosphorylation and LPS binding to TLR4 on macrophages.

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“…Of them, the rhizome of Anemarrhena asphodeloides Bunge (Asparagaceae) is widely administered as traditional medicine in China, Korea and Japan for the treatment of inflammatory disorders, including fever, coughs, allergies, diabetes, and Alzheimer's disease (7,8). Numerous previous studies support the use of A. asphodeloides for the treatment of various inflammatory disorders.…”

Section: Introductionmentioning

confidence: 99%

Suppression of inflammation by the rhizome of Anemarrhena asphodeloides via regulation of nuclear factor-κB and p38 signal transduction pathways in macrophages

Kim

Cho

et al. 2017

Biomedical Reports

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Abstract. The rhizome of Anemarrhena asphodeloides Bunge (A. asphodeloides) has been used as a traditional East Asian medicine for the treatment of various types of inflammatory disease. However, to the best of our knowledge, there have been no systemic studies regarding the molecular mechanisms of action of the A. asphodeloides rhizome anti-inflammatory effects. The aim of the present study was to elucidate the anti-inflammatory effects and underlying mechanism of action of ethanol extracts of the rhizome of A. asphodeloides (EAA) in murine macrophages. Non-cytotoxic concentrations of EAA (10-100 µg/ml) significantly decreased the production of NO and interleukin (IL)-6 in lipopolysaccharide (LPS)-stimulated macrophages, while the production of tumor necrosis factor-α was not regulated by EAA. EAA-mediated reduction of nitric oxide (NO) was due to reduced expression levels of inducible NO synthase (iNOS). Furthermore, protein expression levels of LPS-induced cyclooxygenase-2, another inflammatory enzyme, were alleviated in the presence of EAA. EAA-mediated reduction of those proinflammatory mediators was due to inhibition of nuclear factor-κB (NF-κB) and activator protein 1 transcriptional activities followed by the stabilization of inhibitor of κ Bα and inhibition of p38, respectively. These results indicate that EAA suppresses LPS-induced inflammatory responses by negatively regulating p38 and NF-κB, indicating that EAA is a candidate treatment for alleviating inflammation.

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The genus Anemarrhena Bunge: A review on ethnopharmacology, phytochemistry and pharmacology

Cited by 130 publications

References 65 publications

Development and validation of liquid chromatography–tandem mass spectrometry method for simultaneous determination of six steroidal saponins in rat plasma and its application to a pharmacokinetics study

Development and validation of liquid chromatography–tandem mass spectrometry method for simultaneous determination of six steroidal saponins in rat plasma and its application to a pharmacokinetics study

The Rhizome Mixture of Anemarrhena asphodeloides and Coptidis chinensis Ameliorates Acute and Chronic Colitis in Mice by Inhibiting the Binding of Lipopolysaccharide to TLR4 and IRAK1 Phosphorylation

Suppression of inflammation by the rhizome of Anemarrhena asphodeloides via regulation of nuclear factor-κB and p38 signal transduction pathways in macrophages

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