Purpose This paper aims to investigate the way in which blockchain technology is likely to influence future supply chain practices and policies. Design/methodology/approach A systematic review of both academic and practitioner literature was conducted. Multiple accounts of blockchain adoption within industry were also consulted to gain further insight. Findings While blockchain technologies remain in their infancy, they are gaining momentum within supply chains, trust being the predominant factor driving their adoption. The value of such technologies for supply chain management lies in four areas: extended visibility and traceability, supply chain digitalisation and disintermediation, improved data security and smart contracts. Several challenges and gaps in understanding and opportunities for further research are identified by this research. How a blockchain-enabled supply chain should be configured has also been explored from a design perspective. Research limitations/implications This systematic review focuses on the diffusion of blockchain technology within supply chains, and great care was taken in selecting search terms. However, the authors acknowledge that their choice of terms may have excluded certain blockchain articles from this review. Practical implications This paper offers valuable insight for supply chain practitioners into how blockchain technology has the potential to disrupt existing supply chain provisions as well as a number of challenges to its successful diffusion. Social implications The paper debates the poential social and economic impact brought by blockchain. Originality/value This paper is one of the first studies to examine the current state of blockchain diffusion within supply chains. It lays a firm foundation for future research.

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This research uses sensemaking theory to explore how emerging blockchain technology may transform supply chains. We investigate three research questions (RQs): What are blockchain technology's perceived benefits to supply chains, where are disruptions mostly likely to occur and what are the potential challenges to further blockchain diffusion? We conducted in-depth interviews with 14 supply chain experts. Cognitive mapping and narrative analysis were deployed as the two main data analysis techniques to aid our understanding and evaluation of people's cognitive complexity in making sense of blockchain technology. We found that individual experts developed different cognitive structures within their own sensemaking processes. After merging individual cognitive maps into a strategic map, we identified several themes and central concepts that then allowed us to explore potential answers to the three RQs. Our study is among the very few to date to explicitly explore how blockchains may transform supply chain practices. Using the sensemaking approach afforded a deeper understanding of how senior executives diagnose the symptoms evident from blockchains and develop assumptions, expectations and knowledge of the technology, which will then shape their future actions regarding its utilisation. We demonstrate the usefulness of sensemaking theory as an alternative lens in investigating contemporary supply chain phenomena such as blockchains. Bringing sensemaking theory to this discipline in particular enriches emerging behavioural operations research. Our contributions also lie in extending the theories of prospective sensemaking and adding further insights to the stream of technology adoption studies.

SummaryAbnormalities in cartilage and bone development in the Apert syndrome FGFR2 +/S252W

Carbon dots that exhibit near-infrared fluorescence (NIR CDs) are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents. Despite progress in the synthesis of NIR CDs, there remains a key obstacle to using them as an in vivo theranostic agent. This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy (PTT) in mouse models (conversion efficiency of 59%) and can be readily visualized by photoluminescence and photoacoustic imaging. The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting. Contrary to all other nanomaterials that have been tested in biomedicine, they are excreted through the body’s renal filtration system. Moreover, after intravenous injection, NIR CDs are accumulated in tumor tissue via passive targeting, without any active species such as antibodies. Due to their accumulation in tumor tissue without the need for intratumor injection, high photothermal conversion, excellent optical and photoacoustic imaging performance, and renal excretion, the developed CDs are suitable for transfer to clinical biomedical practice.

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Wearable sensing technology is an essential link to future personalized medicine. However, to obtain a complete picture of human health, it is necessary but challenging to track multiple analytes inside the body simultaneously. Here, we present a wearable plasmonic-electronic sensor with “universal” molecular recognition ability. Flexible plasmonic metasurface with surface-enhanced Raman scattering (SERS)–activity is introduced as the fundamental sensing component in a wearable sensor since we solved the technical challenge of maintaining the plasmonic activities of their brittle nanostructures under various deformations. Together with a flexible electronic sweat extraction system, our sensor can noninvasively extract and “fingerprint” analytes inside the body based on their unique SERS spectra. As a proof-of-concept example, we successfully monitored the variation of trace-amounts drugs inside the body and obtained an individual’s drug metabolic profile. Our sensor bridges the existing gap in wearable sensing technology by providing a universal, sensitive molecular tracking means to assess human health.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for the major cause of dementia, and the increasing worldwide prevalence of AD is a major public health concern. Increasing epidemiological studies suggest that diet and nutrition might be important modifiable risk factors for AD. Dietary supplementation of antioxidants, B vitamins, polyphenols, and polyunsaturated fatty acids are beneficial to AD, and consumptions of fish, fruits, vegetables, coffee, and light-to-moderate alcohol reduce the risk of AD. However, many of the results from randomized controlled trials are contradictory to that of epidemiological studies. Dietary patterns summarizing an overall diet are gaining momentum in recent years. Adherence to a healthy diet, the Japanese diet, and the Mediterranean diet is associated with a lower risk of AD. This paper will focus on the evidence linking many nutrients, foods, and dietary patterns to AD.