The genetics of generalized vitiligo and associated autoimmune diseases

Spritz, Richard A.

doi:10.1016/j.jdermsci.2005.10.001

Cited by 109 publications

(119 citation statements)

References 56 publications

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“…• Genetic factors: several candidate genes and genetically linked loci have been identified that appear to mediate susceptibility to generalized vitiligo [9].…”

Section: Pathogenesismentioning

confidence: 99%

Surgical management of vitiligo

Mulekar¹

2010

Expert Review of Dermatology

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Vitiligo is a common condition characterized by hypopigmented and/or depigmented spots on the skin, affecting approximately 1-2% of the world population. Until approximately 30 years ago, it was exclusively treated by medical therapies. The most commonly used medical therapies include topical steroids, calcineurin inhibitors and phototherapy. Lesions on the face and neck respond the best to medical therapies, followed by lesions on the proximal extremities and trunk, while those distributed over acral parts of extremities and nonhairy areas, such as the wrist, feet and male genitals, respond poorly. Surgical methods complement medical therapies by providing melanocytes to these refractory lesions, and are indicated for unilateral segmental and clinically stable bilateral vitiligo, refractory to medical treatment. Tissue-grafting methods include minigrafting or punch grafting, epidermal grafting and split thickness grafting. These methods use full-thickness punch grafts, roof of epidermal blisters and shave biopsy samples, respectively, as the source of melanocytes. Cellular grafting includes noncultured and cultured melanocytes/keratinocytes suspensions obtained from trypsinizing the shaved skin biopsy sample as a source of melanocytes. Recent advances over the years have enabled dermatologists to treat extensive areas located on any anatomic site in a single operative session by surgical intervention. The purpose of this review is to describe the selection criteria for the surgical treatment, their utility and limitations in the various types of vitiligo.

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“…• Genetic factors: several candidate genes and genetically linked loci have been identified that appear to mediate susceptibility to generalized vitiligo [9].…”

Section: Pathogenesismentioning

confidence: 99%

Surgical management of vitiligo

Mulekar¹

2010

Expert Review of Dermatology

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“…But we do not know how many major genes may be involved in NSV and in what different combinations. Actually only genes associated with autoimmune susceptibility such as HLA, PTPN22, NALP1 and CTL4 have been identified with reasonable certainty [29,30]. Many other candidate genes have been suggested and studied for NSV which were involved in melanocyte development, cell adhesion and transportation of melanosomes [31].…”

Section: Sv and Nsv As Separate Entitiesmentioning

confidence: 99%

New Insights in Mixed Vitiligo: Initial Non Segmental Vitiligo can precede the Onset of Segmental Vitiligo (Cases Report and Review of Theories)

Benzekri¹,

Gauthier²

2014

Pigmentary Disorders

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Recently, mixed vitiligo (MV) was defined by Mulekar as the association of segmental vitiligo (SV) and nonsegmental vitiligo (NSV) in the same patient. Until now, SV and generalized NSV were considered to be separate entities with a different distribution (unilateral or bilateral). Generalized vitiligo seemed to be more frequently associated with other autoimmune diseases than SV. From the pathophysiological standpoint, it was hypothesized that NSV was an autoimmune disease, while SV may result of a sympathetic dysfunction. The first pediatric case of SV associated with NSV was reported in 2003 and 36 other observations were subsequently reported. In all these cases, segmental involvement associated usually in a second step with the onset of bilateral vitiligo patches. In this article, we describe, for the first time, two atypical cases of mixed vitiligo in which NSV involvement preceded the onset of SV. In the light of these remarkable cases, different possible aetiopathogenetic mechanisms of MV are discussed which may provide new insights into the pathogenesis of vitiligo.

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“…The etiology of vitiligo is uncertainly though genetic, immunological, biochemical (including oxidative stress) and neurogenic factors may interact to contribute to its development [2]. Vitiligo can be classified into segmental and non-segmental vitiligo.…”

Section: Introductionmentioning

confidence: 99%

“…Medical treatment includes the use of immune-modulating drug such as systemic corticosteroids, vitamin supplements (especially vitamin B12 and folic acid). Light-based treatment includes psoralen photo chemotherapy (PUVA) and NB-UVB [2].…”

Section: Introductionmentioning

confidence: 99%

Comparison Treatment of Vitiligo by Co-culture of Melanocytes Derived from Hair Follicle with Adipose-Derived Stem Cells with and without NB-UVB

Saleh¹,

Abdel-salam²,

Metwally³

et al. 2017

Pigmentary Disorders

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Objective: The aim of this work is to evaluate treatment of vitiligo by co-culture of melanocytes derived from hair follicle with adipose-derived stem cells with (NB-UVB) and without (NB-UVB). Patients and methods:In this study, we used co culture of adipose derived stem cell with melanocytes derived from hair follicle in treating different types of stable resistant vitiligo, by two methods transplantation: group (A) exposed to (NB-UVB), group (B) did not expose to (NB-UVB). They are followed up for 3 months.Results: At the end of the follow up period which was 3 months group (A) showed better pigmentary response than group (B) and it was highly statistically significant. Stability, size, site and onset of vitiligo appeared to be important factors affecting treatment results. Using (NB-UVB) also after injection of the treatment showed more improvement in the treatment results. Conclusion:Co-culture of adipose derived stem cell with melanocytes derived from hair follicle could be a safe and effective method of treatment for stable localized vitiligo in patients resistant to other methods of therapy.

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The genetics of generalized vitiligo and associated autoimmune diseases

Cited by 109 publications

References 56 publications

Surgical management of vitiligo

Surgical management of vitiligo

New Insights in Mixed Vitiligo: Initial Non Segmental Vitiligo can precede the Onset of Segmental Vitiligo (Cases Report and Review of Theories)

Comparison Treatment of Vitiligo by Co-culture of Melanocytes Derived from Hair Follicle with Adipose-Derived Stem Cells with and without NB-UVB

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