The genetic epidemiology of alopecia areata in China

Yang, Sen; Yang, Jun‐Qi; Liu, J.B.; Wang, H.Y.; Yang, Qing; Gao, Min; Liang, Yanhua; Lin, Guo Shu; Lin, Da; Hu, Xingxing; Fan, Li; Zhang, X.J.

doi:10.1111/j.1365-2133.2004.05915.x

Cited by 90 publications

(111 citation statements)

References 23 publications

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“…In our study, approximately 10% of all patients with AA experienced onset at age 50 years and above. This coincides with data from previous epidemiological studies, which describe 14.5 and 7.1% of AA patients experiencing onset beginning at age 40 and 50, respectively [2,8,11] . While our results, like several other studies [10,11,13] , show a decline in incidence of lateonset AA with advancing age, it was not statistically significant, perhaps due to the small study group.…”

Section: Discussionsupporting

confidence: 78%

Late-Onset Alopecia Areata: A Retrospective Cohort Study

et al. 2017

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Background: Alopecia areata is an immune-mediated disease presenting with sudden onset of nonscarring hair loss. Onset is more common earlier in life, and little is known regarding late-onset alopecia areata. Objectives: To describe the epidemiology, clinical patterns, disease course, and outcome of late-onset alopecia areata in Israeli patients referred to a tertiary medical center. Materials and Methods: This retrospective cohort study considered patients whose disease onset occurred at age ≥50 years. Patients were recruited from among all alopecia areata patients visiting a tertiary center between January 2009 and April 2015. Results: Of the 29 people included, 25 (86.2%) were female (female-to-male ratio, 6.2:1). There was a family history of alopecia areata in 17.2%, thyroid disease in 31%, atopic background in 6.9%, and 17/29 (58.6%) reported a significant stressful event. The most common disease pattern was patchy, and disease was mild in the majority of participants. Complete hair regrowth was observed in 82.8% of participants, and 37.9% relapsed. Conclusion: Late-onset alopecia areata is characterized by marked female predominance, less extensive disease, and a high incidence of complete hair regrowth.

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Section: Discussionsupporting

confidence: 78%

Late-Onset Alopecia Areata: A Retrospective Cohort Study

et al. 2017

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“…Positive family history is associated with early age of onset, and increased risk of thyroid disease is most evident in those patients with a family history of AA. Positive family history among first-degree relatives has been reported to be as high as 47% for patients with early onset, in contrast to 1.6% for all patients (14).…”

Section: Clinical Featuresmentioning

confidence: 98%

Lymphocytes, neuropeptides, and genes involved in alopecia areata

Gilhar¹,

Paus²,

Kalish³

2007

J. Clin. Invest.

257

270

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Many lessons in autoimmunity -particularly relating to the role of immune privilege and the interplay between genetics and neuroimmunology -can be learned from the study of alopecia areata, the most common cause of inflammation-induced hair loss. Alopecia areata is now understood to represent an organ-restricted, T cell-mediated autoimmune disease of hair follicles. Disease induction is associated with collapse of hair follicle immune privilege in both humans and in animal models. Here, the role of HLA associations, other immunogenetic factors, and neuroendocrine parameters in alopecia areata pathogenesis are reviewed. This instructive and clinically significant model disease deserves more widespread interest in the immunology community.Nonstandard abbreviations used: AA, alopecia areata; AIRE, autoimmune regulator; APECED, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy; IP-10, IFN-g-inducible protein 10; MIC, MHC class I chain-related; MIF, macrophage migration inhibitory factor; α-MSH, α-melanocyte-stimulating hormone; NALP1, NACHT leucine-rich-repeat protein 1; NGF, nerve growth factor.

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“…AA olgularının çoğunluğu sporadik olarak ortaya çıkar. Pozitif aile öyküsü yapılan yayınlarda %4.6 ile %42 arasında değişmektedir (5,16,17). Küçük yayınlarda aile öyküsü görülme sıklığı daha fazla bulunmuştur (18)(19)(20).…”

Section: Discussionunclassified

Clinical Features and Prognosis of Juvenil Alopecia Areata Patients

Özden¹,

Bayramoglu²,

Aydın³

et al. 2010

Turk J Dermatol

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Objective: Although alopecia areata (AA) affects both adults and children, there is limited information about juvenile AA. In this study the properties of juvenile AA, associated diseases and trigger factors were reviewed. Material ve Methods:We have examined the data of 54 AA patients under 16 years of age. We have re-contacted these patients and evaluated the course of the features of the disease and collected information about triggering factors, starting age, attack number, alopecia type, severity and localization of disease duration, full blood count, biochemistry and thyroid function tests, family history and the prognosis in the following years. Results: We could not detect any significant relationship between the presence of a trigger factor and severity of the clinical picture. Similarly, no relationship between duration of illness, gender, and the trigger factor was found. Seven (12.96%) patients had an underlying endocrinological disease. There was no significant relationship between the severity of clinical condition and the endocrine disease. Sixteen patients (29.6%) had a family history of AA with 1.2. or 3 degree relatives. Conclusion: While disease duration, gender and trigger factors did not have a significant relationship, family history was found to affect clinical severity. Another striking result was the stable severity in the presence of trigger factors. (Turk J Dermatol 2010; 4: 60-5)

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The genetic epidemiology of alopecia areata in China

Abstract: The effect of genetic factors is strong in AA, but environmental factors such as infection and psychological stress may still play an important role. Our findings on the genetics of AA are consistent with a polygenic additive mode of inheritance.

Cited by 90 publications

References 23 publications

Late-Onset Alopecia Areata: A Retrospective Cohort Study

Late-Onset Alopecia Areata: A Retrospective Cohort Study

Lymphocytes, neuropeptides, and genes involved in alopecia areata

Clinical Features and Prognosis of Juvenil Alopecia Areata Patients

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