The Future of Drug Delivery

Gao, Jingjing; Karp, Jeffrey M.; Langer, Robert; Joshi, Nitin

doi:10.1021/acs.chemmater.2c03003

Cited by 89 publications

(53 citation statements)

References 33 publications

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“…However, the mRNA vaccines that were successfully used during the current COVID-19 pandemic have underpinned renewed interest in nanotechnology-enabled materials for healthcare nanoparticle drug delivery studies over the past decades and, coupled with advances in cell biology and genetic engineering, have paved the way for the next generation of biologics delivery that we see today. This observation is in accordance with the latest editorial published by one of MODERNA’s founders and one of the pioneers of drug delivery, Robert Langer, and his colleagues Jeffrey Karp, Nitin Joshi, and Jingjing Gao entitled “The Future of Drug Delivery” . The authors are optimistic about the future, noting that “Looking forward, the future of drug delivery is bright”.…”

supporting

confidence: 81%

The Future of Healthcare Materials

Khashab

Caruso

2023

Chem. Mater.

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supporting

confidence: 81%

The Future of Healthcare Materials

Khashab

Caruso

2023

Chem. Mater.

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“…A meticulous selection process was undertaken to identify a set of 23 significant factors, previously established in studies, that are closely linked to the properties of drug encapsulation and the methods employed for the preparation of NPs (45)(46)(47). The relevant drug properties were obtained from the Drugbank database (48).…”

Section: Data Extractionmentioning

confidence: 99%

Unraveling the Intricacies of Nanoparticle Targeting of Brain Therapeutics for Enhanced Efficacy

Yousfan

Rahwanji

Hanano

et al. 2023

Preprint

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The delivery of drugs to specific target tissues and cells in the brain poses a significant challenge in brain therapeutics, primarily due to a limited understanding of how nanoparticle properties influence drug biodistribution and off-target organ accumulation. This study addresses the limitations of previous research by presenting a novel and innovative approach that utilizes a large dataset incorporating both numerical and categorical features. Unlike previous studies, which often suffer from inadequate data and accuracy, our focus is specifically on brain delivery in vivo testing. Through a systematic analysis of 403 data points, including measurements of brain and plasma area under the curve (AUC) following nanoparticle (NP) administration, we extensively characterized the chemical and physical properties of loaded drugs and NPs as carriers. Utilizing machine learning techniques and comprehensive literature data analysis, we developed accurate models for predicting NP delivery to the brain. Our analysis employed various linear models, with a particular emphasis on the superior performance of linear mixed-effects models. These models demonstrated exceptional accuracy, as indicated by high R2 and adjusted R2 scores, in predicting the delivery of NPs to the brain. This breakthrough provides a valuable tool for guiding the design of nanocarriers in clinical applications, resulting in reduced experimental costs and the mitigation of unintended biological outcomes. To validate our models, we synthesised and administered two distinct NP formulations via intranasal (IN) and intravenous (IV) routes, further substantiating the efficacy of our proposed models. Among the various modeling approaches, linear mixed-effects models exhibited superior performance in capturing underlying patterns.

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“…The use of targeted nanoparticles increases the possibility of reducing the side effects of antitumor drugs by administrating lower but more precisely targeted doses to specific tissues ( Scheme 1 ) [ 19 ]. Magnetic nanoparticles (MNPs) have been studied and applied in biomedicine owing to their physical and chemical properties, such as good solubility, high drug-loading capacity, magnetic hyperthermia, magnetic resonance imaging (MRI), excellent biocompatibility, and biodegradability [ 20 ]. The application of magnetic nanoparticles offers several benefits for drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Supermagnetic Nanocomposites Coated with Pluronic F127 as a Contrast Agent for Biomedical Applications

et al. 2023

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Nanomedicine has garnered significant interest owing to advances in drug delivery, effectively demonstrated in the treatment of certain diseases. Here, smart supermagnetic nanocomposites based on iron oxide nanoparticles (MNPs) coated with Pluronic F127 (F127) were developed for the delivery of doxorubicin (DOX) to tumor tissues. The XRD patterns for all samples revealed peaks consistent with Fe3O4, as shown by their indices (220), (311), (400), (422), (511), and (440), demonstrating that the structure of Fe3O4 did not change after the coating process. After loading with DOX, the as-prepared smart nanocomposites demonstrated drug-loading efficiency and drug-loading capacity percentages of 45 ± 0.10 and 17 ± 0.58% for MNP-F127-2-DOX and 65 ± 0.12 and 13 ± 0.79% for MNP-F127-3-DOX, respectively. Moreover, a better DOX release rate was observed under acidic conditions, which may be credited to the pH sensitivity of the polymer. In vitro analysis demonstrated the survival rate of approximately 90% in HepG2 cells treated with PBS and MNP-F127-3 nanocomposites. Furthermore, after treatment with MNP-F127-3-DOX, the survival rate decreased, confirming cellular inhibition. Hence, the synthesized smart nanocomposites showed great promise for drug delivery in liver cancer treatment, overcoming the limitations of traditional therapies.

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The Future of Drug Delivery

Cited by 89 publications

References 33 publications

The Future of Healthcare Materials

The Future of Healthcare Materials

Unraveling the Intricacies of Nanoparticle Targeting of Brain Therapeutics for Enhanced Efficacy

Synthesis and Characterization of Supermagnetic Nanocomposites Coated with Pluronic F127 as a Contrast Agent for Biomedical Applications

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