Synthesis and Characterization of Supermagnetic Nanocomposites Coated with Pluronic F127 as a Contrast Agent for Biomedical Applications

Abstract

Nanomedicine has garnered significant interest owing to advances in drug delivery, effectively demonstrated in the treatment of certain diseases. Here, smart supermagnetic nanocomposites based on iron oxide nanoparticles (MNPs) coated with Pluronic F127 (F127) were developed for the delivery of doxorubicin (DOX) to tumor tissues. The XRD patterns for all samples revealed peaks consistent with Fe3O4, as shown by their indices (220), (311), (400), (422), (511), and (440), demonstrating that the structure of Fe3O4 did not change after the coating process. After loading with DOX, the as-prepared smart nanocomposites demonstrated drug-loading efficiency and drug-loading capacity percentages of 45 ± 0.10 and 17 ± 0.58% for MNP-F127-2-DOX and 65 ± 0.12 and 13 ± 0.79% for MNP-F127-3-DOX, respectively. Moreover, a better DOX release rate was observed under acidic conditions, which may be credited to the pH sensitivity of the polymer. In vitro analysis demonstrated the survival rate of approximately 90% in HepG2 cells treated with PBS and MNP-F127-3 nanocomposites. Furthermore, after treatment with MNP-F127-3-DOX, the survival rate decreased, confirming cellular inhibition. Hence, the synthesized smart nanocomposites showed great promise for drug delivery in liver cancer treatment, overcoming the limitations of traditional therapies.

Application of Nanoparticles for Magnetic Hyperthermia for Cancer Treatment—The Current State of Knowledge

“…Nonorganic SPION-type nanostructures are rapidly eliminated from the body. Therefore, various polymeric modifications are used to improve the biological performance of SPIONs, such as the combination of polyethylene glycol (PEG), β-cyclodextran, the non-ionic detergent Pluronic F127, and chitosan [ 55 , 56 ]. Surface modifications of SPIONs also involve the attachment of ligands, which act as vectors to increase the likelihood of direct delivery into the tumor niche.…”

The Advancing Role of Nanocomposites in Cancer Diagnosis and Treatment

“…The LbL assembly involves a sequential deposition of oppositely charged nanoparticles and polymers to form a multilayer structure. [13][14][15] Characterization techniques play a pivotal role in evaluating the properties and performance of nanocomposites for cancer applications. Common characterization techniques include dynamic light scattering (DLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) [14][15][16][17] (Figure 1).…”

“…[13][14][15] Characterization techniques play a pivotal role in evaluating the properties and performance of nanocomposites for cancer applications. Common characterization techniques include dynamic light scattering (DLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) [14][15][16][17] (Figure 1). Each of these techniques provides a unique assessment of the properties of the nanocomposite.…”

“…Various techniques can be employed for synthesis, including the sol-gel method, in-situ polymerization, and layer-by-layer (LbL) assembly. 13 , 14 While the sol-gel method involves the hydrolysis and condensation of precursors to form a gel network that encapsulates nanoparticles, the in-situ polymerization involves the polymerization of monomers in the presence of nanoparticles, leading to their incorporation into the polymer matrix. The LbL assembly involves a sequential deposition of oppositely charged nanoparticles and polymers to form a multilayer structure.…”

“…The synthesis and characterization of nanocomposites for cancer applications also involve developing advanced materials with unique properties tailored for diagnosis and treatment. Recent research highlights notable examples include smart supermagnetic nanocomposites, 14 Yttrium oxide nanocomposites, 19 ZnO–TiO 2 –Chitosan–Escin nanocomposites, 15 branched magnetic nanocomposites, 18 and Copper Oxide–Titanium Oxide–Chitosan–Amygdalin nanocomposites. 17 Supermagnetic nanocomposites, based on iron oxide nanoparticles coated with Pluronic F127, have been synthesized for targeted drug delivery in cancer therapy, 14 and polymer-gated and superparamagnetic nanoparticle embedded hollow mesoporous silica nanoparticles as a smart multifunctional nanocarrier for targeted and controlled drug delivery for cancer treatment.…”