The further epidemiological differentiation of cleft lip and palate: A population study of clefts in King County, Washington, 1956–1965

Emanuel, Irvin; Bh, Culver; Jd, Erickson; Guthrie, Bridgette D.; Schuldberg, D

doi:10.1002/tera.1420070308

Cited by 60 publications

(44 citation statements)

References 15 publications

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“…9,10,39-49 The outcomes were not clearly defined in 29 studies. 14, [16][17][18]21,22,26,27,39,[49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] Thirty-three studies did not define the exposure variables 7,8,14,15,18,22,23,34,40,41,[50][51][52][53][54][56][57][58][59][60][61][62][63][64][65][66]…”

Section: Quality Assessmentmentioning

confidence: 99%

Parental age as a risk factor for non-syndromic oral clefts: A meta-analysis

Herkrath

Rebelo

et al. 2012

Journal of Dentistry

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Section: Quality Assessmentmentioning

confidence: 99%

Parental age as a risk factor for non-syndromic oral clefts: A meta-analysis

Herkrath

Rebelo

et al. 2012

Journal of Dentistry

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“…Some patients have already received surgical repair of cleft defect, which have healed, or are being prepared for surgery, or are recovering from surgical repair during questionnaire administration, while some others were seen for the first time during questionnaire administration. Hence, the treatment protocol depended on the age at questionnaire administration, and the type of treatment already given [14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

“…Scaling and polishing with oral hygiene instructions were not a prominent feature of the treatment needs because of the age at presentation of these patients. More than 80% of the patients were below the age of 5 years [14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Perceived and Normative Needs of Facial Cleft Patients Seen in Nigeria

Amobi

Mafeni

Adekoya-Sofowora

2018

Pesqui. bras. odontopediatria clín. integr.

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Objective: To evaluate the pattern of presentation and assessing treatment needs of children with facial clefts. Material and Methods: This was a cross sectional study of 49 patients seen at the cleft clinic of Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife for a 39-month period of study. Data collected were patient's bio-data including age, date of birth, sex, social class, age of parents, dental findings, associated malformations, treatment given and referral using an interviewer-administered questionnaire. Data was analyzed using the Statistical Package for Social Sciences. Frequency distributions were carried out for all variables and the Pearson Chi-Square Test was applied to assess the significance of differences between groups at a p value of 0.05. Results: Cleft lip and palate had the highest preponderance 23 (47.0%) followed by cleft lip 14 (28.6%) and cleft palate 12 (24.5%). There were more females 28 (57.14%) than males 21 (42.9%) at male to female ratio of 3: 4, though; it was not statistically significant (p-0.73). Most of the patients (73.5%) belong to the low social class. The high social class had 13 (26.5%) cases. Conclusion: The most important treatment needs of cleft patients in this study were: review/follow-up of treatment protocol, oral hygiene instructions, cleft palate repair, cleft lip repair, and referral to the Orthodontist for treatment of varying degrees of malocclusion in descending order. This trend in the treatment needs arose because most of the patients were still ignorant of the implications of managing facial cleft defects through the multi-disciplinary treatment approach.

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“…For example, it appears as if male infants have a higher incidence of cleft lip with or without cleft palate than do female infants, whereas the reverse is true for isolated cleft palate (Fraser, 1970;Emanuel et al, 1983;Shaw et al, 1991). There are also ethnic variations in terms of prevalence, with Asian populations having a high incidence and African-American clefting rates being rather low (Khoury et al, 1983;Shaw et al, 1991).…”

Section: Etiology Of Ntds and Craniofacial Malformationsmentioning

confidence: 99%

Neural Tube and Craniofacial Defects With Special Emphasis On Folate Pathway Genes

Finnell

Greer

Barber

et al. 1998

Critical Reviews in Oral Biology & Medicine

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Neural tube and orofacial defects are common congenital malformations in humans. While etiologically heterogeneous, they are for the most part multifactorial in their pathogenesis, having both genetic and environmental components in their development. In recent years, there has been a great deal of epidemiologic evidence demonstrating that women who received multivitamins containing folic acid periconceptionally had significantly reduced occurrence and recurrence risks for producing infants with such malformations. This risk reduction is not observed in all populations, further suggestive of a genetic regulation of this phenomenon. Unfortunately, the mechanisms underlying the beneficial effects of folic acid are not wellunderstood. In this article, we review the relevant epidemiologic data on both neural tube defects and orofacial malformations, the fundamental embryological processes involved in closing the neural tube, and the development of the craniofacies, and propose a working hypothesis for susceptibility to these malformations. This hypothesis is based on the interworkings of cellular folate transport, focusing on the key elements involved in potocytosis. We propose that infants with mutations in the folate receptor alpha gene might be at increased risk for congenital anomalies due to a reduced binding affinity for 5-methyltetrahydrofolate, the physiologic form of folic acid. Various experimental approaches to test the working hypothesis are considered.Key words. Folic acid, birth defects, genetic susceptibility. Clinical DescriptionNeural tube defects (NTDs) are common congenital malformations that occur when the embryonic neural tube, which ultimately forms the brain and spinal cord, fails to close properly during the first few weeks of development. Anencephaly, which is invariably fatal, is characterized by the nearly complete degeneration of exposed anterior neural tube tissue (Hunter, 1993). The superficially "brain-like" mass of exposed tissue typically consists of collagen and connective and vascular tissue covered by an epithelial membrane (Hunter, 1993). When the brain is completely absent, the defect is referred to as holo-anencephaly, which occurs in approximately 65% of failed anterior neural tube closure (Myrianthopoulos and Melnick, 1987). A more mild malformation, meroanencephaly, involves the protrusion of the cerebrovasculosa through a partially formed skull (Myrianthopoulos and Melnick, 1987). According to Hunter (1993), approximately half of anencephalic infants are stillbirths, while the remainder live for variable periods of up to 48 hours.The other major NTD is spina bifida, which involves the protrusion of neural tissue through an opening in the vertebral arches and may occur anywhere along the length of the spinal cord. The severity of the defect can range from craniorachischisis, where the entire anterior and posterior neural tube is open, to a lesion limited to a single vertebral level. The vast majority of spina bifida lesions are found in the lumbar (42.2%) or lumbos...

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The further epidemiological differentiation of cleft lip and palate: A population study of clefts in King County, Washington, 1956–1965

Cited by 60 publications

References 15 publications

Parental age as a risk factor for non-syndromic oral clefts: A meta-analysis

Parental age as a risk factor for non-syndromic oral clefts: A meta-analysis

Perceived and Normative Needs of Facial Cleft Patients Seen in Nigeria

Neural Tube and Craniofacial Defects With Special Emphasis On Folate Pathway Genes

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