Parental age as a risk factor for non-syndromic oral clefts: A meta-analysis

Herkrath, Ana Paula Corrêa de Queiroz; Herkrath, Fernando José; Rebelo, Maria Augusta Bessa; Vettore, Mário Vianna

doi:10.1016/j.jdent.2011.10.002

Cited by 89 publications

(75 citation statements)

References 69 publications

(174 reference statements)

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“…With respect to maternal age as a risk factor for the occurrence of NSCL/P, we adopted the categories (maternal age <35, 36-39 and ≥40 years) recently cited in a meta-analysis study 18 . In the present study, we found no association between maternal age and clefts (p=0.747).…”

Section: Resultsmentioning

confidence: 99%

“…All patients were carefully examined and screened for the presence of associated anomalies or syndromes by a team of specialists from each center, and the clefts were classified with the incisive foramen as reference 8 . Paternal ages were classified into the following groups: maternal age <35, 36-39, and ≥40 years; paternal age <39 and ≥40 years 18 . Patients with congenital malformations (other than oral cleft), history of consanguinity or history of familial NSCL/P were not included in this study.…”

Section: Methodsmentioning

confidence: 99%

“…In the meta-analysis study 18 , fathers aged 40 years or more showed an increased risk of having a child with CP compared to their peers between 20 and 39 years old. An extensive study suggested predominance in females when the father is age 40 years or older 13 .…”

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confidence: 98%

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Parental age is related to the occurrence of cleft lip and palate in Brazilian populations

et al. 2017

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Aim: To evaluate the association of environmental risk factors, particularly paternal and maternal age, with gender and type of oral cleft in newborn with nonsyndromic cleft lip with or without cleft palate (NSCL/P). Methods: This study included 1,346 children with NSCL/P of two Brazilian Services for treatment of craniofacial deformities. Parental ages were classified into the following groups: maternal age <35, 36-39, and ≥40 years; paternal age <39 and ≥40 years. The data was analyzed with chi-square test and multinomial logistic regression analysis. The odds ratios were estimated with a 95% confidence interval. Results: Of the 1,346 children included in this study, CLP was the type of NSCL/P with highest prevalence, followed by, respectively, CL and CP. There was a greater occurrence of NSCL/P in males compared to females (55.8% versus 44.2%). CLP was more common in men, while the CL and CP were more prevalent in women (p=0.000). No association between maternal age and clefts was observed (p=0.747). However, there was evidence of association between father's aged ≥40 years old and NSCL/P (p=0.031). When patients with CP were analyzed separately, no association between the father's age and the child's gender (p=0.728) was observed, i.e. the female gender prevails among patients with CP, regardless of the father's age. Conclusions: This study showed that there were differences in the distribution of the non-syndromic cleft lip and/ or palate and the gender, and fathers aged ≥40 years old may have increased risk of oral cleft. Further studies involving different populations are needed for a better understanding of the effect of maternal and paternal ages as a risk factor for the occurrence of oral clefts.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Parental age is related to the occurrence of cleft lip and palate in Brazilian populations

et al. 2017

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“…Mothers between 35 and 39 were also at statistically higher risk of generating a child with CP than those between 20 and 29 years. [6] Bille et al [28] also observed an association between advanced maternal and paternal age and increased the risk of birth with CL/P, although only advanced paternal age has been associated with an increased risk of CP.…”

Section: Literature Reviewmentioning

confidence: 95%

“…[4] Maternal exposure to environmental factors during the embryonic development period may increase the likelihood of an embryo to develop structural anomalies that include cleft lip and palate. [5] In a recent systematic review, 14 different classifications were found for cleft lip and palate, and the most widely used classification divides clefts into two groups, cleft lip with or without cleft palate (CL/P) and cleft palate (CP), [6] as they are etiologically distinct, both embryologically as epidemiologically.…”

Section: Literature Reviewmentioning

confidence: 99%

Cleft lip and palate: Associated genetic and environmental factorsImmunodeficiency Virus

Neves¹,

Vieira²,

Aranha³

et al. 2015

SJOD

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Cleft lip and palate are among the most common craniofacial anomalies of the human species causing considerable morbidity to affected individuals. The etiology of isolated or non-syndromic cleft lip and palate is complex and heterogeneous, and its occurrence is associated with the interaction of different genetic and environmental factors. To explore the genetic and environmental factors involved in the etiology of non-syndromic cleft lip and palate, an extensive literature review was conducted on PubMed and SciELO databases. A number of environmental factors such as smoking, alcohol consumption, diet quality, supplementation with folic acid, exposure to chemicals and contaminants, parental age and medication use may be associated with mutations in several genes increasing the risk of development of cleft lip and cleft palate. Advances in the study of gene-environment interactions and the expansion of knowledge about its etiology should lead to improvements in the prevention, diagnosis and treatment of non-syndromic cleft lip and palate.

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Birth prevalence of orofacial clefts among perinatal infants: A register‐based study in Bao'an district, Shenzhen, China

Luo

Wang

Gao³

et al. 2019

Birth Defects Research

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Background: The birth prevalence of orofacial clefts (OFCs) has been widely studied, but results are considerable varied, and epidemiological studies in southern China are few in numbers. To address this gap, we carried out a register-based study to estimate the birth prevalence of OFCs in Bao'an district, Shenzhen, China. Methods: Data of perinatal infants born between 2003 and 2017 were extracted from Shenzhen Maternal and Child Health Management System. The overall OFCs birth prevalence with 95% confidence interval (CI) as well as subgroup analysis based on selected demographic factors was conducted. Cochran-Armitage trend tests were applied to evaluate the time trend by 5-year intervals. Results: The overall birth prevalence of OFCs, cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO) was 1.30 (95% CI 1.21-1.39), 1.00 (95% CI 0.92-1.08), and 0.30 (95% CI 0.25-0.34) per 1,000 births, respectively. An overall declining tendency was observed in the OFCs (from 1.83 to 1.04 per 1,000 births), specifically CL/P (from 1.53 to 0.69 per 1,000 births) birth prevalence over 5-year intervals, with statistical significance (p < 0.01). Subgroup analysis revealed that the CL/P and CPO birth prevalence was differed by infant gender, household registration, maternal age, and parity. Conclusion: Our findings had firstly reported the birth prevalence of OFCs in Bao'an district, and might help other researchers to plan more comprehensive public health strategies to reduce the occurrence of OFCs in further generation.

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Parental age as a risk factor for non-syndromic oral clefts: A meta-analysis

Cited by 89 publications

References 69 publications

Parental age is related to the occurrence of cleft lip and palate in Brazilian populations

Parental age is related to the occurrence of cleft lip and palate in Brazilian populations

Cleft lip and palate: Associated genetic and environmental factorsImmunodeficiency Virus

Birth prevalence of orofacial clefts among perinatal infants: A register‐based study in Bao'an district, Shenzhen, China

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