The frequent and the unusual red cell phenotypes in Indian blood donors: A quest for rare donors

Setya, Divya; Tiwari, Aseem Kumar; Arora, Dinesh; Mitra, Subhasis; Mehta, Sharad; Aggarwal, Geet

doi:10.1016/j.transci.2020.102765

Cited by 11 publications

(2 citation statements)

References 10 publications

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“…In the Kidd blood group system, the frequencies of Jka and Jkb antigens in our study were observed to be 60.2% and 66.8% respectively. Shah et al and Setya et al reported similar results of the frequencies [24,25]. However, Makarovska-Bojadzieva et al from the Republic of Macedonia reported different results with low frequencies of both Jka and Jkb at 7.7% and 2.5% respectively [26].…”

Section: Discussionmentioning

confidence: 81%

Frequency of Extended Red Cell Antigen Phenotype Among Patients of Hematological Diseases: A Single Center Study

Tariq¹,

Ahmed²,

Ashfaq³

et al. 2022

Cureus

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BackgroundAlloimmunization of erythrocytes is a major problem in patients with hematological diseases that require frequent blood transfusions. Matching of extended red cell antigens of Kell, MNS, Kidd, and Duffy can decrease the risk of alloimmunization. Hence, in this study, the frequencies of the extended red cell phenotypes were explored. ObjectiveTo find out the frequency of extended red blood cell antigen phenotypes among patients with hematological diseases. MethodsThis cross-sectional research study was performed on 488 patients diagnosed with hematological diseases who required blood transfusion at the National Institute of Blood Disease and Bone Marrow Transplantation Karachi for a period of 1.42 years from November 2019 to March 2021. The blood of patients was analyzed for antigen phenotypes of different blood group systems including Kell, MNS, Kidd, and Duffy. The data obtained were interpreted. ResultsAmong the 488 patients, 284 (58.20%) patients were male, and 204 (41.80%) patients were female with a mean age of 8.1 years. Beta thalassemia was the most common hematological disease reported in 354 (72.5%) of the patients. The most common blood group was O positive reported in 182 (37.3%) of the patients followed by B positive blood group in 124 (25.4%). The frequencies of extended red cell antigen phenotypes in the patients were K antigen 14 (2.9%), Kp a antigen 26 (5.3%), Kp b antigen 424 (86.9%), Fy a antigen 360 (73.8%), Fy b antigen 260 (53.3%), Jk a antigen 294 (60.2%), Jk b antigen 326 (66.8%), M antigen 410 (84.0%) and N antigen 306 (62.7%). ConclusionBeta thalassemia was the most common hematological disease followed by iron deficiency anemia, aplastic anemia, and acute leukemia. Patients with hematological diseases had a higher prevalence of Kp b antigen followed by M, Fy a , Jk b , N, Jk a , Fy b , Kp a, and K antigen. O positive was the most frequent blood group followed by B positive, A positive and AB positive blood group.

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Section: Discussionmentioning

confidence: 81%

Frequency of Extended Red Cell Antigen Phenotype Among Patients of Hematological Diseases: A Single Center Study

Tariq¹,

Ahmed²,

Ashfaq³

et al. 2022

Cureus

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“…Thus the special blood type of blood donors is more likely to be missed in blood type screening, resulting in severe clinical events such as HTRs 2 . A large number of studies have shown that the screening of UAb before blood transfusion is very important and necessary for blood transfusion safety 3 , 4 . Therefore, in blood transfusion safety, the donor's blood group is the more important, in the prevention of allo immunisation and possible transfusion reactions (HTRs).…”

Section: Introductionmentioning

confidence: 99%

Establishment and application of suspension static method in blood group screening of automated blood group analyzer

Huang

et al. 2023

Sci Rep

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The accuracy of blood group identification is the basis of blood transfusion safety. In order to increase the detection rate of weak agglutination, unexpected antibodies (UAb) and blood subtypes for pre-transfusion testing, the blood group screening process of automated blood group analyzer (ABGA) is ameliorated by introducing one static step and establishing a suspension static method (SSM). One static step was introduced in the blood group screening process of ABGA and three static time conditions were designed: 300 s, 400 s and 500 s, from which the optimal static time was selected and SSM was established; By comparing the detection of weak agglutination and UAb before and after the application of SSM, the feasibility and effect of suspension static method were verified and evaluated. The last two steps of the automatic blood group screening process were replaced with static, light centrifugation and imaging. The optimal static time parameter was selected as 400 s and SSM was established; After the application of SSM, it was verified that: (1) The detection level of weak antibodies (anti-A and anti-B) and weak antigens (weak D phenotype) could be improved by SSM, including antibodies in plasma of known type O samples with 0, 2, 4, 8, 16 and 32 times serial dilutions(simulating weak anti-A and weak anti-B), weak antibodies (anti-B) in plasma of one normal A-type sample and weak antigens on red blood cells (RBC) of 5 weak D phenotype samples (weak D antigen); (2) Three blood donor samples (type A, O and B) with known UAb were detected by SSM. The results showed that SSM could detect both weak antibodies (anti-A and anti-B) and UAb; (3) SSM was applied to detect the samples of 3 A2B and 3 subtype B blood donors and the blood subtypes could be clearly detected; (4) The number of screening samples was 95,314 and 106,814 before SSM (2018) and after (2020) the application of SSM and the positive rate of UAb (63/95,314 and 187/106,814) increased after SSM, discrepancy of which was statistically significant (χ2 = 48.42, P < 0.01). The above results demonstrate that SSM of ABGA is conducive to the detection of weak agglutination, UAb and blood subtypes in blood samples, which can improve the sensitivity of blood group detection and ensure the safety of clinical blood transfusion to a certain extent.

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Anti-D Alloimmunization After RhD Positive Red Cell Transfusion to Selected RhD Negative Patients

Pandey

Setya

Singh

2022

Indian J Hematol Blood Transfus

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The frequent and the unusual red cell phenotypes in Indian blood donors: A quest for rare donors

Cited by 11 publications

References 10 publications

Frequency of Extended Red Cell Antigen Phenotype Among Patients of Hematological Diseases: A Single Center Study

Frequency of Extended Red Cell Antigen Phenotype Among Patients of Hematological Diseases: A Single Center Study

Establishment and application of suspension static method in blood group screening of automated blood group analyzer

Anti-D Alloimmunization After RhD Positive Red Cell Transfusion to Selected RhD Negative Patients

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