The Frequency and Typing of Human Papilloma Virus Among Women with Normal and Abnormal Cytology in Southern Khorasan, Eastern Iran

Javanmard, Davod; Namaei, Mohammad Hasan; Haghighi, Fatemeh; Ziaee, Masood; Behravan, Mahmoodreza; Mirzaei, Jamal; Ghanbarzadeh, Nahid; Khazaei, Zohreh; Zangoie, M; Naseh, N; Ataei, Mahshid; Sharifzadeh, Gholam Reza; Salehabadi, Alireza; Ghannadkafi, Malaknaz

doi:10.5812/jjm.43213

Cited by 8 publications

(7 citation statements)

References 32 publications

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“…A list of included studies is shown in Table 1. The HPV prevalence and genotypes were investigated in 10,081 women with normal cervical cytology, 19–34 there were 158 women with atypical squamous cells of undetermined significance (ASCUS) or atypia, 27,32,34–37 360 women with low‐grade squamous intraepithelial lesion (LSIL) or cervical intraepithelial neoplasia I (CIN I), 27,32,34–42 183 women with high‐grade squamous intraepithelial lesion (HSIL) or CIN II‐III, 32,35–40,43 and 1111 women with invasive cervical cancer (ICC) 19,23,29,32,35–40,44–50 . As indicated in Table 2, the overall HPV prevalence was found to be 9% (CI = 6–14) in women with a normal cervix, 55% (CI = 34–75) in ASCUS (atypia) cases, 58% (CI = 43–73) in women with LSIL (CIN I), 69% (CI = 52–82) in HSIL (CIN II‐III) cases, and 81% (CI = 71–88) among women with ICC (Figures 2–3).…”

Section: Resultsmentioning

confidence: 99%

A meta‐analysis of human papillomavirus prevalence and types among Iranian women with normal cervical cytology, premalignant lesions, and cervical cancer

Salavatiha

Farahmand

Shoja

et al. 2021

Journal of Medical Virology

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In this study, all data from Iran on human papillomavirus (HPV) prevalence and types among women with normal cervical cytology, premalignant lesions, and cervical cancer were obtained and pooled. The overall HPV prevalence was found to be 9% in women with a normal cervix, 55% in atypical squamous cells of undetermined significance or atypia cases, 58% and 69% in women with low and high grade squamous intraepithelial lesions, respectively, and 81% among women with invasive cervical cancer. In all of the studied groups, HPV 16 was the most common HPV type, followed by HPV 18. In conclusion, this meta‐analysis revealed that it will be beneficial if current HPV vaccines are integrated into the national vaccination programs of Iran.

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Section: Resultsmentioning

confidence: 99%

A meta‐analysis of human papillomavirus prevalence and types among Iranian women with normal cervical cytology, premalignant lesions, and cervical cancer

Salavatiha

Farahmand

Shoja

et al. 2021

Journal of Medical Virology

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“…Studies related to the prevalence of HPV in Iranian women have estimated the prevalence of the virus in different provinces to be 5.5%–36. 5% [ 18 – 24 ]. The virus has been reported to be more prevalent in women with sexually transmitted infections and cervical cancer, as well as in women with high-risk behaviors [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation Frequency of Human Papillomavirus and Its Related Genotypes in Women of the General Population Living in 11 Provinces of Iran

Hassani

Nadji

Mohseni

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Introduction. Persistent infection with one of the most high-risk genotypes of human papillomavirus causes all cases of cervical cancer and a significant proportion of other genital cancers. The HPV virus, unlike any other infection that leads to cancer, is transmitted only through sexual intercourse and is less affected by the general changes and development in lifestyle and medical standards, so only vaccination and screening can prevent the HPV virus and cancers caused by it. Therefore, determining the prevalence and distribution of HPV genotypes are of utmost importance in screening strategies regarding cervical cancer and vaccination decisions against HPV that vary based on the geographical and cultural characteristics of the study area. As a result, this study aimed to determine the frequency of human papillomavirus and the distribution of this virus’s genotypes in the general population of women living in 11 provinces of Iran. Materials and Methods. This study is a community-based survey study. Sampling was done by the cluster sampling method. Women aged 15–59 years old from the general population living in 11 provinces of Iran were included in the study after considering the inclusion and exclusion criteria. Data were collected using a questionnaire and vaginal examination. The study was performed on 2562 vaginal specimens that were referred to the laboratory of the present study. HPV genome was detected by the nested MY-GP method and papillomavirus genotyping was performed using the PCR multiplex method to identify 19 papillomavirus genotypes. Results. The general prevalence of HPV in the 11 provinces was obtained at 2.4% (108 out of 2562 people). The highest prevalence of the virus was in the age group of 25–34 years. The prevalence of HPV was statistically significant among different provinces. Hormozgan province with 22 cases (5.9%) had the highest and Isfahan province with 6 cases (2.2%) had the lowest incidence of HPV. The prevalence of high-risk HPV and medium-risk HPV is 3%, and the prevalence of low-risk HPV was estimated to be 2.1% of the total female population. Also, the highest prevalence was related to genotype 16. Conclusion. According to the high prevalence of the HPV virus in young age groups in Iran, it is necessary to pay attention to screening programs to reduce the incidence of cervical cancer.

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“…HPV DNA was detected by using the nested-PCR (nPCR) method. The universal primers MY09/11 (outer) and GP5+/6+ (inner) were used for L1 amplification and the detection of HPV-positive specimens according to previous protocols (5,6). The Bio-Rad T100™ Thermal cycler was used for the polymerase chain reaction.…”

Section: Hpv Detectionmentioning

confidence: 99%

“…The Bio-Rad T100™ Thermal cycler was used for the polymerase chain reaction. Furthermore, Beta globin as an external PCR control was used following the previous protocols (5,6). The heating program was as follows: 1st at 95°C for 5min, 45st at 95°C for 30 s, 56°C for 30 s (for outer primers), 48°C for 30 s (for inner primers), 72°C for 45 s, and 1st at 72°C for 5 min.…”

Section: Hpv Detectionmentioning

confidence: 99%

Detection of Human Papilloma Virus (HPV) Infection in Colorectal Cancer and Viral Genome Integration Status

et al. 2022

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Background: Colorectal cancer (CRC) is the third common cause of malignancy in Iran, and its incidence rate has been raised due to an increase in individual and environmental risk factors. Objectives: The present study aimed to define the role of human papillomavirus (HPV) infection in CRC, then by drawing a phylogenetic tree, we aimed to analysis the sequences of isolated HPVs, and finally determine the viral genome physical status for HPV-16. Methods: A nested-PCR (nPCR), direct sequencing, and INNO-LiPA HPV genotyping assay were carried out for HPV detection, and a quantitative real-time PCR assay (qRT-PCR) was conducted for the physical status of the viral genome. Results: Among 157 subsets, there were 66 cases and 91 controls. Moreover, 5.7% (9/157) were HPV positive by nPCR, among whom 9.1% (6/66) were cases and 3.3% (3/91) were control groups (P = 0.750). The qRT-PCR analysis showed three forms of integrated, episomal, and mixed forms in our three HPV-16 strains. A higher rate of HPV infection was detected in the CRC cases; however, it was not statistically significant. Conclusions: Although there were limited positive results, higher ages (> 65) were related to HPV involvement and CRC outcome. Furthermore, 9.1% of the CRC cases were infected with HPVs. The HPV-16 genome integration is observed in high-grade cancer cases with severe malignancy in CRC patients.

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The Frequency and Typing of Human Papilloma Virus Among Women with Normal and Abnormal Cytology in Southern Khorasan, Eastern Iran

Abstract: Background: Infection by certain types of human papilloma virus (HPV) is known as a causal and essential factor for cervical cancer, the second most common malignancy in women around the world.

Cited by 8 publications

References 32 publications

A meta‐analysis of human papillomavirus prevalence and types among Iranian women with normal cervical cytology, premalignant lesions, and cervical cancer

A meta‐analysis of human papillomavirus prevalence and types among Iranian women with normal cervical cytology, premalignant lesions, and cervical cancer

Evaluation Frequency of Human Papillomavirus and Its Related Genotypes in Women of the General Population Living in 11 Provinces of Iran

Detection of Human Papilloma Virus (HPV) Infection in Colorectal Cancer and Viral Genome Integration Status

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