A meta‐analysis of human papillomavirus prevalence and types among Iranian women with normal cervical cytology, premalignant lesions, and cervical cancer

Salavatiha, Zahra; Farahmand, Mohammad; Shoja, Zabihollah; Jalilvand, Somayeh

doi:10.1002/jmv.26928

Cited by 14 publications

(15 citation statements)

References 52 publications

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“…Persistent HR-HPV infection, the most common of which are HPV16 and HPV18, is the leading cause of cervical precancerous lesions and cervical cancer [20]. HPV-E6 and E7 proteins induce cellular immune escape, disrupt the normal cell cycle, and cause abnormal cell reproduction and tendency for malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

Nomogram for predicting pathological discordance between colposcopy and cold knife conization findings in patients with colposcopically confirmed high-grade squamous intraepithelial lesions

Wang

Bai

et al. 2022

Preprint

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Background: Inaccurate colposcopic diagnosis results in inappropriate management of cervical lesions. This study aimed to develop a nomogram for predicting the probability of discordance between colposcopic and cold knife conization (CKC) pathological findings. Methods: We retrospectively reviewed the records of patients colposcopically diagnosed with high-grade squamous intraepithelial lesions (HSIL) who underwent CKC at the Second Hospital of Shanxi Medical University from September 2018 to September 2021. To evaluate the accuracy of colposcopy for identifying HSIL, the pathological results of colposcopy and CKC were compared, with CKC results considered as the comparative gold standard. To determine the factors influencing colposcopic accuracy, the correlations between pathological discordance and clinical parameters were assessed by univariate and multivariate logistic regression. Based on the multivariate analysis results, a nomogram was developed and validated internally. Results: Data from 607 patient records were analyzed. The colposcopic accuracy rate for identifying HSIL was 72.8%. Multivariate analysis showed that cervical intraepithelial neoplasia (CIN) grade 3 (OR=9.455, P<0.001), positive endocervical curettage (ECC) (OR=5.407, P<0.001), findings of HSIL/atypical squamous cells-cannot exclude HSIL (ASC-H)/atypical glandular cells (AGC) (OR=1.791, P=0.044), and peripheral blood lymphocyte count (OR=0.523, P=0.018) were associated with colposcopic underestimation, while CIN 3 (OR=0.422, P<0.001), positive ECC (OR=0.306, P<0.001), findings of HSIL/ASC-H/AGC (OR=0.423, P=0.004), and peripheral blood monocyte count (OR=7.989, P=0.016) were associated with colposcopic overestimation. The above factors were used to construct nomograms for predicting colposcopic under- and overestimation, which had area under the curve values of 0.815 (95% CI: 0.767-0.863) and 0.742 (95% CI: 0.690-0.793) for under- and overestimation, respectively. Conclusions: Our results suggested a significant discordance between colposcopic and conization pathological results, which can lead to unnecessary biopsies or delayed treatment. Our nomogram models may help estimate the probability of colposcopic under- and overestimation, thus aiding clinicians to create individualized treatment plans.

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Section: Discussionmentioning

confidence: 99%

Nomogram for predicting pathological discordance between colposcopy and cold knife conization findings in patients with colposcopically confirmed high-grade squamous intraepithelial lesions

Wang

Bai

et al. 2022

Preprint

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“…Several studies have shown that the incidence of HR-HPV genotypes is related to the severity of abnormal lesions in cytology [ 22 , 23 ]. Recently, Salavatiha et al, in a meta-analysis of HPV prevalence among Iranian women, revealed that the overall HPV incidence was 9% in females with a healthy cervix and 55% in ASCUS [ 24 ]. Therefore, it is valuable to consider the diagnostic methods, percussion, and identification of individuals with this disease to prevent cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of high-risk human papillomavirus genotypes and related risk factors among Iranian women

et al. 2022

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Human papillomavirus (HPV) infection, which often includes high-risk genotype infection, is one of the leading causes of cervical cancer. This cross-sectional research included 503 Iranian women referred to the gynecology clinic of Kamali Hospital in Karaj, Iran, for routine cervical cancer screening between 2020 and 2021. Cervical specimens were collected from all participants with a special brush and transported to the laboratory for cervical cytology diagnosis. Overall HPV incidence among Iranian women was 39.96%, of which 23.06% had high-risk HPV genotypes and 9.7% had low-risk HPV types. The risk associated with HR-HPV types was considerably associated with employment and marital status.

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“…The global prevalence estimated at 11.7% and HPV will infect 80% of women in their lifetime [1,2]. The HPV prevalence is estimated to be 9.3% among women in the East Mediterranean region (EMR) [3], while its prevalence was 9 % in Iranian females [4]. Persistent HPV infection with high-risk types such as HPV type 6, 11, 16, and 18 cause almost all cases of cervical cancer, genital wart, and some anal, vaginal, penile, and oropharyngeal cancers [5].…”

Section: Introductionmentioning

confidence: 99%

Cost–Benefit Analysis of Human Papillomavirus Vaccine in Iran

et al. 2022

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Background: Despite increasing global attention to the national human papillomavirus (HPV) immunization program, this program is controversial in Iran. Evidence indicate that HPV vaccination is not cost-effective in Iran. Using cost-effectiveness analysis for decision-making about public health interventions such as vaccination is debated, because its potential bene ts may not t this framework. Our objective was to evaluate economic effects of HPV vaccination by cost-bene t analysis (CBA). In this case, we used bivalent and quadrivalent in Iran in 2020.Methods: We performed a CBA from a societal perspective. We used two approaches of the vaccine's

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A meta‐analysis of human papillomavirus prevalence and types among Iranian women with normal cervical cytology, premalignant lesions, and cervical cancer

Cited by 14 publications

References 52 publications

Nomogram for predicting pathological discordance between colposcopy and cold knife conization findings in patients with colposcopically confirmed high-grade squamous intraepithelial lesions

Nomogram for predicting pathological discordance between colposcopy and cold knife conization findings in patients with colposcopically confirmed high-grade squamous intraepithelial lesions

The prevalence of high-risk human papillomavirus genotypes and related risk factors among Iranian women

Cost–Benefit Analysis of Human Papillomavirus Vaccine in Iran

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