The French Armed Forces Virology Unit: A Chronological Record of Ongoing Research on Orthopoxvirus

Delaune, D.; Iseni, Frédéric; Ferrier-Rembert, Audrey; Peyrefitte, Christophe N.; Ferraris, Olivier

doi:10.3390/v10010003

Cited by 3 publications

(3 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Variola virus (smallpox virus), a member of the orthopoxvirus (OPV) genus of the family poxviridae, was used in the 18th century as a biological warfare agent by British and American forces in North America [36], and remains on the top of the list of biological threat agents for warfare or bioterrorism [35,107]. Effective vaccines and FDAapproved antivirals exist and could be used to control a deliberate release.…”

Section: Poxviridaementioning

confidence: 99%

“…Smallpox virus infection leads to a fatal multiorgan failure syndrome within 7-14 days, in complicated cases with a hemorrhagic syndrome and CNS involvement. Smallpox has played a role in large-scale epidemics in history and its causative agent continues to be considered a potential biological warfare agent [35]. Orthopoxviruses (OPV) are ovoid-shaped enveloped viruses with Group I double-stranded (ds) DNA genomes, replicating via a virus-encoded DNA polymerase, an antivirals target, in the cytoplasm of infected cells [42].…”

Section: Poxviridaementioning

confidence: 99%

“…Anti-poxvirus drugs. One of the first effective drugs in clinical use as a parenteral treatment in severe OPV infections was cidofovir, a bisphosphonate developed at REGA, in Belgium [31,35]) and FDA approved against human cytomegalovirus (HCMV). The ether lipid analogue brincidofovir (CMX001), a prodrug of cidofovir, has shown efficacy in small animal models and is awaiting FDA approval [26,44,56,115,116,118,139].…”

Section: Poxviridaementioning

confidence: 99%

See 2 more Smart Citations

Antivirals in medical biodefense

et al. 2020

View full text Add to dashboard Cite

The viruses historically implicated or currently considered as candidates for misuse in bioterrorist events are poxviruses, filoviruses, bunyaviruses, orthomyxoviruses, paramyxoviruses and a number of arboviruses causing encephalitis, including alpha-and flaviviruses. All these viruses are of concern for public health services when they occur in natural outbreaks or emerge in unvaccinated populations. Recent events and intelligence reports point to a growing risk of dangerous biological agents being used for nefarious purposes. Public health responses effective in natural outbreaks of infectious disease may not be sufficient to deal with the severe consequences of a deliberate release of such agents. One important aspect of countermeasures against viral biothreat agents are the antiviral treatment options available for use in post-exposure prophylaxis. These issues were adressed by the organizers of the 16th Medical Biodefense Conference, held in Munich in 2018, in a special session on the development of drugs to treat infections with viruses currently perceived as a threat to societies or associated with a potential for misuse as biothreat agents. This review will outline the state-of-the-art methods in antivirals research discussed and provide an overview of antiviral compounds in the pipeline that are already approved for use or still under development.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

show abstract

Section: Poxviridaementioning

confidence: 99%

Section: Poxviridaementioning

confidence: 99%

Section: Poxviridaementioning

confidence: 99%

See 1 more Smart Citation

Antivirals in medical biodefense

et al. 2020

View full text Add to dashboard Cite

show abstract

Social, Cognitive, and Emotional Predictors of Adherence to Physical Distancing During the COVID-19 Pandemic

Gouin

MacNeil

Switzer

et al. 2020

Preprint

View full text Add to dashboard Cite

Objectives. To identify targetable psychosocial predictors of adherence to physical distancing during the COVID-19 pandemic using theories of health behaviour change. Methods. Using a cross-sectional sample (N = 1003) representative of the population in terms of age, gender, and urbanicity in Quebec, Canada, we examined social, cognitive, and emotional predictors of adherence to physical distancing. Results. Individuals were more likely to report adhering to physical distancing if they believed it is their civic duty to adhere (injunctive personal norms), that physical distancing will benefit others and the broader crisis (perceived benefits for others), and if they perceive that other people are following these directives (descriptive social norms). In contrast, perceived personal risk and emotional factors were not significantly related to physical distancing. Moderation analyses revealed unique predictors depending on health risk status, essential workers status, and urbanicity.Conclusions. These results highlight the importance of health beliefs and perceived social norms in shaping responses to physical distancing directives, and offer insights into ways to frame public health communications for different segments of the population.

show abstract

Orf Nodule with Erythema Multiforme during a Monkeypox Outbreak, France, 2022

Cavalieri¹,

Dupond²,

Ferrier-Rembert³

et al. 2023

Emerg. Infect. Dis.

Self Cite

View full text Add to dashboard Cite

MPXV from infected deer mice. Overall, shedding, as suggested by the presence of MPXV DNA in swab extracts, was readily detectable in deer mice inoculated with either clade II virus at day 4, but we noted decreasing levels of positivity by day 10. Shedding of MPXV/V79-1-005 (clade 1) was far less than that of either of the clade II viruses we evaluated (Table ).Our study suggests that these rodents may support a short-term but abortive infection with at least clade II MPXV isolates, although with limited capacity to spread. Given the short duration of infection, these animals probably do not represent a viable enzootic reservoir for MPXV. Further studies should be conducted on other rodents in North America and Europe to assess their competency as vectors or reservoirs of MPXV. Particular interest should be given to Rattus species rodents that may frequently come into contact with medical waste containing viable MPXV.

show abstract

The French Armed Forces Virology Unit: A Chronological Record of Ongoing Research on Orthopoxvirus

Cited by 3 publications

References 67 publications

Antivirals in medical biodefense

Antivirals in medical biodefense

Social, Cognitive, and Emotional Predictors of Adherence to Physical Distancing During the COVID-19 Pandemic

Orf Nodule with Erythema Multiforme during a Monkeypox Outbreak, France, 2022

Contact Info

Product

Resources

About