The flash visual evoked potential-P2 and the detection of amnestic mild cognitive impairment: A review of empirical literature

Standardization and Validation of the Flash Visual Evoked Potential-P2 Conversion Scores in the Diagnosis of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia

“…As can be seen in Figure 2, the treatment effect associated with the present samples ( d = .79) was smaller, on average, than the treatment effect associated with previous research ( d = 1.03) 1 but was still consistent with the overall findings of the original review, which indicated a robust, selective delay of the FVEP-P2 latency in response to impaired cholinergic functioning. However, the use of FVEP-P2 Conversion Scores in the present example provides a much richer context from which to examine the performance of the present sample of AD patients by controlling for clinic-specific differences in apparatus and recording parameters.…”

“…Building on the suggestion made by Odom et al 25,26 and extending the findings from the review conducted by Arruda et al 1 the present article will illustrate, by way of example, the process by which the FVEP-P2 latency can be standardized across clinics using the FVEP-P2 Conversion Scores , which employs the published means and standard deviations of known published investigations involving the use of the FVEP-P2 in the early diagnosis of aMCI or AD. 1 We will then expand these findings by demonstrating the diagnostic accuracy of the newly developed FVEP-P2 Conversion Scores in the detection of AD using two different cut-off criteria and the previously unpublished data of Coburn et al 2…”

“…Transform the newly derived z-scores to FVEP-P2 Conversion Scores for both AD patients and age equivalent controls using the mean (143.92 ms) and standard deviation (17.13) of controls obtained from the previous published review. 1 The raw score formula used can be seen below.Where X i is now the FVEP-P2 Conversion Score, Z i is the newly z-score transformed P2 latency; X false¯ is the mean latency of review controls (143.92 ms), and s is the standard deviation of review controls (17.13).…”

“…Figure 1 illustrates the probability density function for the FVEP-P2 latencies associated with control and patient populations examined in the original review. 1 Each probability function was constructed using the (grand) weighted means and standard deviations obtained from the 17 investigations identified, which collectively possessed a mean latency of 143.92 ms ( SD = 17.13) and 164.02 ms ( SD = 21.33) for the control and patient populations, respectively (Cohen's d = 1.03). An associated table containing the latencies and corresponding z-scores for just the control population can be seen below (Table 2).…”

Research on Voxel-Based Features Detection and Analysis of Alzheimer’s Disease Using Random Survey Support Vector Machine

“… Bi et al (2020a; 2021b ) applied the random forest to identify features associated with AD. Another study showed that the Flash Visual Evoked Potential-P2 latency had AD-specific pathological information ( Arruda et al, 2020 ). Sabuncu et al (2011) calculated the degree of atrophy of hippocampus and cortical areas and found that the specific cortical thinning and the reduction of hippocampal volume were accelerated in early AD.…”