The first infant case of COVID-19 acquired from a secondary transmission in Vietnam

Le, Hai Thanh; Nguyen, Lam Van; Tran, Dien Minh; T, Hai; Trần, Hương; Le, Yen T; Phan, Phuc Huu

doi:10.1016/s2352-4642(20)30091-2

Cited by 81 publications

(92 citation statements)

References 4 publications

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“…Asymptomatic infection: without any clinical symptoms and signs and the chest imaging is normal, while the SARS-CoV-2 nucleic acid test was positive or the serum-specific antibody was retrospectively diagnosed as infection. 3 | RESULTS Twenty studies were case reports, [20][21][22][23][24][25][26][27][28]31,32,35,[37][38][39][40][41][42][43]45 11 were case series 5,[15][16][17][18][19]29,30,33,34,44 and six were retrospective studies. 3,[10][11][12][13][14]36 With the exception of five multicenter studies, 5,[10][11][12]36 all others were unicentric studies.…”

Section: Data Extractionmentioning

confidence: 99%

“…Thirty-three studies were conducted in China, 3,5,[10][11][12][13][14][15][16][17][18][19][20][21][22][24][25][26][27]29,30,[32][33][34][35][36][37][39][40][41][42][43][44] one in Italy, 38 one in Iran, 45 one in Singapore, 28 one in Korea, 23 and one in Vietnam. 31…”

Section: Data Extractionmentioning

confidence: 99%

“…3,[11][12][13]16,17,19,45 Zheng et al 12 Normal or decreased platelet counts were detailed in 15 studies, involving 32 cases. 16,[23][24][25]27,29,[31][32][33]35,37,[39][40][41]45 Normal platelet counts were reported in 78.1% (22/32) and decreased in 3.2% (1/32) of cases. Increased platelet counts were reported in 6 of 63 (9.5%) cases.…”

Section: Laboratorial Characteristicsmentioning

confidence: 99%

“…11,16,[23][24][25]27,29,[31][32][33]35,37,[39][40][41]45 Elevated C-reactive protein (CRP) levels were described in 59 of 305 cases (19.3%), reported in 25 studies. 3,11,13,16,[19][20][21][22][23][24]26,27,29,[31][32][33][34][35][36][37][39][40][41][42]45 Zheng et al 12 reported in 16 studies. 3,11,13,16,24,26,27,31,33,36,…”

Section: Laboratorial Characteristicsmentioning

confidence: 99%

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Clinical manifestations of children with COVID‐19: A systematic review

Souza

Nadal

Nogueira

et al. 2020

Pediatric Pulmonology

230

163

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Background: The coronavirus disease 2019 (COVID-19) outbreak is an unprecedented global public health challenge, leading to thousands of deaths every day worldwide. Despite the epidemiological importance, clinical patterns of children with COVID-19 remain unclear. The aim of this study was to describe the clinical, laboratorial, and radiological characteristics of children with COVID-19. Methods: The Medline database was searched between December 1st 2019 and April 6th 2020. No language restrictions were applied. Inclusion criteria were (a) studied patients younger than 18 years old; (b) presented original data from cases of COVID-19 confirmed by reverse-transcription polymerase chain reaction; and (c) contained descriptions of clinical manifestations, laboratory tests, or radiological examinations. Results: A total of 38 studies (1124 cases) were included. From all the cases, 1117 had their severity classified: 14.2% were asymptomatic, 36.3% were mild, 46.0% were moderate, 2.1% were severe, and 1.2% were critical. The most prevalent symptom was fever (47.5%), followed by cough (41.5%), nasal symptoms (11.2%), diarrhea (8.1%), and nausea/vomiting (7.1%). One hundred forty-five (36.9%) children were diagnosed with pneumonia and 43 (10.9%) upper airway infections were reported. Reduced lymphocyte count was reported in 12.9% of cases. Abnormalities in computed tomography were reported in 63.0% of cases. The most prevalent abnormalities reported were ground-glass opacities, patchy shadows, and consolidations. Only one death was reported. Conclusions: Clinical manifestations of children with COVID-19 differ widely from adult cases. Fever and respiratory symptoms should not be considered a hallmark of COVID-19 in children.

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Section: Data Extractionmentioning

confidence: 99%

Section: Data Extractionmentioning

confidence: 99%

Section: Laboratorial Characteristicsmentioning

confidence: 99%

Section: Laboratorial Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Clinical manifestations of children with COVID‐19: A systematic review

Souza

Nadal

Nogueira

et al. 2020

Pediatric Pulmonology

230

163

View full text Add to dashboard Cite

show abstract

“…The sensitivity of chest X-ray is supposed to be inferior to that of CT-scan: in adults, nonspecific patchy peripheral and peribronchovascular opacities may be shown in all lung zones, according to the severity of the infection [86]. As children usually develop milder patterns of the disease, chest X-ray may fail to identify typical lesions, and it is mainly adopted in newborns and younger infants [59,63,66]. CT-scan is frequently performed in children with suspected or confirmed SARS-CoV-2 infection (up to 85% of all cases reported).…”

Section: Radiology Findingsmentioning

confidence: 99%

SARS-CoV-2 Infection in Children and Newborns: A Systematic Review

Liguoro

Pozzi

Bonanni

et al. 2020

Preprint

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A recent outbreak of a novel Coronavirus responsible for a Severe Acute Respiratory Syndrome (SARS-CoV-2) is spreading globally. The aim of this study was to systematically review the existing evidence on SARS-CoV-2 infections in pediatric age.An electronic search was conducted in PubMed database. Papers published between the 1st of January and the 7th of April, 2020 including children aged 0-18 years were selected. Fifty-two studies and two reviews were included, with a total sample size of 4.612 children (2.366 males, 51.3%, weighted mean age 7 years). Patients showed mainly mild (1285/2679, 48.5%) and moderate (1035/2679, 39.1%) signs of the infection. Less than 2% of children were admitted to the Pediatric Intensive Care Unit. The most commonly described symptoms were fever (49.2%) and cough (44.1%). Laboratory findings were often unremarkable. Children underwent a chest CT-scan in 85.7% of all cases, and 36% resulted normal. Overall, the estimated mortality was 0.07%. A higher proportion of newborns was severely ill (17%) and dyspnea was the commonest reported sign (40%). Conclusion: SARS-CoV-2 affects children less severely than adults. Laboratory and radiology findings are mainly nonspecific. Larger epidemiological and clinical cohort studies are needed to better understand possible implications of COVID-19 infection in children.

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