2020
DOI: 10.1002/ppul.24885
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Clinical manifestations of children with COVID‐19: A systematic review

Abstract: Background: The coronavirus disease 2019 (COVID-19) outbreak is an unprecedented global public health challenge, leading to thousands of deaths every day worldwide. Despite the epidemiological importance, clinical patterns of children with COVID-19 remain unclear. The aim of this study was to describe the clinical, laboratorial, and radiological characteristics of children with COVID-19. Methods: The Medline database was searched between December 1st 2019 and April 6th 2020. No language restrictions were appli… Show more

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Cited by 236 publications
(223 citation statements)
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“…The median age of hospitalized children was significantly lower than that of non-hospitalized children (7)(8)(9)(10)(11)(12) vs. 36 months ; p=0.001). When comparing symptoms and signs between hospitalized and non-hospitalized children, a significantly higher frequency of irritability, dyspnea, drowsiness, respiratory distress, low oxygen saturation, and hepatomegaly was observed among hospitalized patients; and headache was verified among non-hospitalized ones.…”
Section: Resultsmentioning
confidence: 85%
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“…The median age of hospitalized children was significantly lower than that of non-hospitalized children (7)(8)(9)(10)(11)(12) vs. 36 months ; p=0.001). When comparing symptoms and signs between hospitalized and non-hospitalized children, a significantly higher frequency of irritability, dyspnea, drowsiness, respiratory distress, low oxygen saturation, and hepatomegaly was observed among hospitalized patients; and headache was verified among non-hospitalized ones.…”
Section: Resultsmentioning
confidence: 85%
“…This pattern of symptoms is similar to that described by the pediatric largest case series, mainly from China and Europe, and by systematic reviews. 7,8,[10][11][12] The severity of the clinical condition was clearly higher among younger children, aging up to 3 years, with a frequency of hospitalization four times higher than that of older children, and who required ICU care five times more (Table 2). This finding corroborates the results found in the pediatric largest case series published to date.…”
Section: Discussionmentioning
confidence: 99%
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“…Los pacientes pequeños tuvieron más afección respiratoria y los más grandes pudieron referir síntomas más específicos como anosmia y ageusia, así como localizar síntomas inespecíficos como dolor corporal y de garganta. La tos referida como (16), frecuente en algunas series estuvo presente en (17) menos de la mitad de nuestros pacientes . Los síntomas gastrointestinales presentaron la misma frecuencia que otros síntomas respiratorios como la tos y definitivamente más frecuencia que la dificultad respiratoria.…”
Section: Discussionunclassified
“…Entre os casos analisados nessa revisão, foram reportadas apenas 11 crianças (0,14%) que se enquadraram no quadro de síndrome inflamatória multissistêmica e sete mortes (0,09%), sendo que 76,6% dos pacientes foram expostos a familiares diagnosticados com Covid-19. Como observado em estudos anteriores, as manifestações clínicas em crianças com Covid-19 foram geralmente brandas, sendo as mais frequentes febre e tosse, havendo muitos casos assintomáticos 11,12,15,16 .…”
Section: Desenvolvimentounclassified