The Fate of Propoxur in Rat

Foss, W.; Krechniak, J

doi:10.1007/978-3-642-67729-8_74

Cited by 9 publications

(2 citation statements)

References 3 publications

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“…Pesticides, especially propoxur, are endocrine disruptor, has the ability to copy, enhance (agonist) and inhibit (antagonist) the action of endogenous hormones. Propoxur or C11-H15-N-O3 also commonly called Aprocarb (carbamate compound) is widely used in mosquito repellent poisons which have a risk of damaging health because they can enter the body in three ways: ingested or drunk with contaminated food or drink, inhaled in forms of gas and steam, including those that go directly to the lungs and enter the bloodstream [14] (Foss and Krechniak, 1980). Or absorbed through the skin with or without first causing injury to the skin.…”

Section: Discussionmentioning

confidence: 99%

Propoxur Enhances the Expression of Estradiol Hormone and Estradiol Receptor in Rat

Almasi‐Hashiani¹,

Darwin²,

Hasmiwati³

2019

ATMPH

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Objectives: This study aimed to determine the effect of propoxure exposure toward estradiol hormone expression and estradiol receptors in Rattusnovergicusfemale. Method: Three experimental group were sprayed with mosquito repellant containing propoxur, each group was exposed with different treatment, and one group as a control. All group was observed for six cycles of rat's estrus phase with an exposure duration of 28 days. Rat serum was collected for ELISA assay for investigating the expression of estradiol hormone and estradiol receptor. Results: There were significant differences between the control group and the treatment group exposed to inhaled propoxur for 30 minutes (19.5869 ± 4.9731), 60 minutes (20.0920 ± 5.7529), and 90 minutes (25.8703 ± 4.0753). Propoxur has side effect to the expression of estradiol hormone (p = 0.000). Estradiol receptor (p = 0.008) were also significantly different between control and treatment group exposed to propoxur at 30 minutes (1.8489 ± 0.9017), 60 minutes (2.3844 ± 1.4296), and 90 minutes (3.1634 ± 0.9936). Conclusion: Propoxur enhanced estradiol hormone expression. The longer exposure to propoxur the higher thehormone expression of estradiol receptors.

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Section: Discussionmentioning

confidence: 99%

Propoxur Enhances the Expression of Estradiol Hormone and Estradiol Receptor in Rat

Almasi‐Hashiani¹,

Darwin²,

Hasmiwati³

2019

ATMPH

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“…Akumulasi absorpsi pada kulit hewan dalam waktu 24 jam mendekati 16% (DPR, 1995). Selama dalam rapid phase dengan waktu paruh 0,18-0,26 jam, eliminasi propoxur dengan prosentasi 80-95% terjadi dengan cepat (Foss & Krechniak, 1980). Pada tikus dalam 16 jam, 90% dari radiolabel telah terekskresi 5% pada feses, 25% sebagai senyawa yang mudah menguap dan 60% pada urine sebagai konjugat.…”

Section: Pendahuluanunclassified

Analisis Propoxur pada Sampel Darah Postmortem Tikus Galur Wistar

Wijayati

2017

JBP

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AbstrakBunuh diri menggunakan pestisida merupakan masalah utama di sebagian besar negara di dunia. Kasus fatal bunuh diri akibat keracunan pestisida di negara berkembang umumnya berkisar antara 10-20%. Propoxur (2-isopropoxyphenyl N-methylcarbamat) adalah insektisida dari golongan karbamat yang dikembangkan oleh Bayer AG, Jerman. Pada kasus toksikologi, pemilihan spesimen postmortem yang cocok untuk dilakukan uji sangatlah penting, jika dibandingkan dengan cabang-cabang lain dalam toksikologi forensik toksikologi Darah merupakan spesimen yang dipilih untuk menghitung dan menenetukan kadar obat dan metabolitnya.Penelitian ini menggunakan hewan coba tikus galur wistar yang diberi perlakuan peroral propoxur dosis letal. Sampel diambil dari darah jantung tikus dengan tiga variasi waktu yang berbeda yaitu 4, 16 dan 32 jam setelah perlakuan peroral Analisis propoxur dalam sampel darah menggunakan metode ekstraksi cair-cair. Ekstrak diinjeksikan pada GC-MS. Hasil GC-MS menunjukkan puncak propoxur dengan waktu retensi 4,6 hingga 4,7. Pola kadar propoxur dalam setiap variabel waktu jam ke 4, 16 dan 32 terdapat kecenderungan penurunan kadar.Kata kunci: propoxur, darah, postmortem, gas chromatography-mass spectrometry

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Parameters for Carbamate Pesticide QSAR and PBPK/PD Models for Human Risk Assessment

Knaak

Dary

Okino

et al. 2008

Reviews of Environmental Contamination and Toxicology

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Our interest in providing parameters for the development of quantitative structure physiologically based pharmacokinetic/pharmacodynamic (QSPBPK/PD) models for assessing health risks to carbamates (USEPA 2005) comes from earlier work with organophosphorus (OP) insecticides (Knaak et al. 2004). Parameters specific to each carbamate are needed in the construction of PBPK/PD models along with their metabolic pathways. Parameters may be obtained by (1) development of QSAR models, (2) collecting pharmacokinetic data, and (3) determining pharmacokinetic parameters by fitting to experimental data. The biological parameters are given in Table 1 (Blancato et al. 2000). Table 1 Biological Parameters Required for Carbamate Pesticide Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Models.(a).

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The Fate of Propoxur in Rat

Cited by 9 publications

References 3 publications

Propoxur Enhances the Expression of Estradiol Hormone and Estradiol Receptor in Rat

Propoxur Enhances the Expression of Estradiol Hormone and Estradiol Receptor in Rat

Analisis Propoxur pada Sampel Darah Postmortem Tikus Galur Wistar

Parameters for Carbamate Pesticide QSAR and PBPK/PD Models for Human Risk Assessment

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