Propoxur Enhances the Expression of Estradiol Hormone and Estradiol Receptor in Rat

Abstract

Objectives: This study aimed to determine the effect of propoxure exposure toward estradiol hormone expression and estradiol receptors in Rattusnovergicusfemale. Method: Three experimental group were sprayed with mosquito repellant containing propoxur, each group was exposed with different treatment, and one group as a control. All group was observed for six cycles of rat's estrus phase with an exposure duration of 28 days. Rat serum was collected for ELISA assay for investigating the expression of estradiol hormone and estradiol receptor. Results: There were significant differences between the control group and the treatment group exposed to inhaled propoxur for 30 minutes (19.5869 ± 4.9731), 60 minutes (20.0920 ± 5.7529), and 90 minutes (25.8703 ± 4.0753). Propoxur has side effect to the expression of estradiol hormone (p = 0.000). Estradiol receptor (p = 0.008) were also significantly different between control and treatment group exposed to propoxur at 30 minutes (1.8489 ± 0.9017), 60 minutes (2.3844 ± 1.4296), and 90 minutes (3.1634 ± 0.9936). Conclusion: Propoxur enhanced estradiol hormone expression. The longer exposure to propoxur the higher thehormone expression of estradiol receptors.