The extended gate chemically sensitive field effect transistor as multi-species microprobe

Spiegel, Jan Van der; Lauks, I.; Chan, Paddy K. L.; Babić, Davorin

doi:10.1016/0250-6874(83)85035-5

Cited by 316 publications

(144 citation statements)

References 7 publications

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“…17 A silver/silver chloride (Ag/AgCl) reference electrode was used to support a constant voltage and the extended structure, formed by a PAH/ SiO 2 -Np-AChE modified electrode, was connected to the input pin of the LF356 amplifier. The electrical circuit was closed in an electrolyte solution by using phosphate buffer of low ionic strength (5 mM), as summarized in Figure 1.…”

Section: Methodsmentioning

confidence: 99%

Self-Assembly of SiO<SUB>2</SUB> Nanoparticles for the Potentiometric Detection of Neurotransmitter Acetylcholine and Its Inhibitor

Arruda¹,

Guimarães²,

Ramos³

et al. 2014

j nanosci nanotechnol

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The detection and quantification of neurotransmitter acetylcholine (ACh) are relevant because modifications in the ACh levels constitute a threat to human health. The biological regulator of this neurotransmitter is acetylcholinesterase (AChE), an enzyme that catalyzes the hydrolysis of ACh to choline and acetic acid. However, its activity is inhibited in the presence of organophosphate and carbamate pesticides, compromising the degradation of the neurotransmitter. There has been a growing interest in faster and more sensitive detection systems that include new methods and materials for the determination of the ACh concentration. This paper proposes a potentiometric biosensor for the detection of neurotransmitter ACh and its inhibitors, specifically organophosphate pesticide methamidophos. The biosensor is based on a self-assembled platform formed by poly(allylamine) hydrochloride (PAH) and silicon dioxide nanoparticles (SiO 2 -Np) that contains the immobilized enzyme AChE. First, the responses of the biosensor were investigated for different concentrations of ACh in buffer solutions. After quantifying ACh, the inhibition of AChE in the presence of methamidophos was determined, enabling the quantification of methamidophos expressed as the percentage of enzyme inhibition. The potential advantages of this biosensor include simplicity in building the electrode, possible production on an industrial scale, limited need for qualified personnel to operate the device and low processing cost.

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Section: Methodsmentioning

confidence: 99%

Self-Assembly of SiO<SUB>2</SUB> Nanoparticles for the Potentiometric Detection of Neurotransmitter Acetylcholine and Its Inhibitor

Arruda¹,

Guimarães²,

Ramos³

et al. 2014

j nanosci nanotechnol

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“…The development of the ISFET mimics a commercial Metal Oxide Semiconductor Field Transistor (MOSFET) in which the metal gate electrode is removed, in order to expose the underlying insulator layer to the solution. Based on ISFET, Van Der Spiegel et al 4 , introduced another structure named Extended Gate Field Effect Transistor (EGFET) which has a more flexible shape compared to ISFET, and also presents better long-term stability, since the ions from the chemical environment are excluded from any region close to the FET gate insulator 5 . Recently, several thin films have been widely used as the sensing material of the EGFET pH sensors, such as carbon nanotubes 6 , SnO 2 [7] , ZnO [8] , V 2 O 5 xerogel 9 , V 2 O 5 /HDA [10] , V 2 O 5 /WO 3 [11] , V 2 O 5 /TiO 2 [12,13] .…”

Section: Introductionmentioning

confidence: 99%

Comparative Sensibility Study of WO3 ph Sensor Using EGFET and Ciclic Voltammetry

et al. 2015

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“…The coated lead-wire ISFET (CLISFET)5 is an ion sensor which links coated wire ISE to the gate lead-wire of a conventional field effect transistor (FET), as shown in Fig. 1; it is similar in construction to the extended gate ISFET proposed by Spiegel et al 6 A few studies on ISEs which have the pressed pellet membrane of the isolated TCNQ salt7'8 were reported, plus one study on silver ion selective coated wire electrode by the chemical pretreatment of silver wire containing copper with sulfide.9 The authors wish to report the electrochemical characteristics of the first chemically modified silver ion sensor with organic compound, TCNQ anion radical complex thin film.…”

mentioning

confidence: 99%

A New Silver Ion Sensor with Silver-7,7,8,8-Tetracyano-quinodimethane Film Coupled to a Conventional Field Effect Transistor

Wakida

Ujihira

1986

ANAL. SCI.

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A novel chemical modification employing TCNQ is proposed as a preparation technique of ion sensing membrane. The silver ion sensor which links coated wire electrode to the gate lead-wire of a conventional FET showed linear response to silver ion activity in the range from 10-5 mol dm-3 to 10-' mol dm-3 with an almost Nernstian slope. Hg2+ interfered strongly with Ag(TCNQ:) thin film, however, the selectivity coefficients for other ions were below 10-4. The silver ion sensor gave stable potential after a slight drift during 2.5 h. The response time of the proposed sensor was less than 10 s from low to high concentration and in the reverse case the response time became less than 30 s.

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The extended gate chemically sensitive field effect transistor as multi-species microprobe

Cited by 316 publications

References 7 publications

Self-Assembly of SiO<SUB>2</SUB> Nanoparticles for the Potentiometric Detection of Neurotransmitter Acetylcholine and Its Inhibitor

Self-Assembly of SiO<SUB>2</SUB> Nanoparticles for the Potentiometric Detection of Neurotransmitter Acetylcholine and Its Inhibitor

Comparative Sensibility Study of WO3 ph Sensor Using EGFET and Ciclic Voltammetry

A New Silver Ion Sensor with Silver-7,7,8,8-Tetracyano-quinodimethane Film Coupled to a Conventional Field Effect Transistor

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