The expression of Tim-1 and Tim-4 molecules in regulatory T cells in type 1 diabetes

Guo, Heming; Shen, Yingxiao; Kong, Yinghong; Li, Sicheng; Jiang, Rong; Liu, Cuiping; Chen, Fang; Hu, Ji

doi:10.1007/s12020-019-02173-8

Cited by 8 publications

(8 citation statements)

References 20 publications

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“…Guo et al. have evaluated the frequencies of circulating TIM1 + Tregs and TMI4 + Tregs (Figure 3) in patients with TID 283 . Their study revealed that TIM1 + Tregs and TMI4 + Tregs were significantly decreased in PBMCs of patients with T1D as compared with healthy people.…”

Section: Treg Subsets In Autoimmune Diseasementioning

confidence: 99%

Different subpopulations of regulatory T cells in human autoimmune disease, transplantation, and tumor immunity

Jiang

Zhu

Wang

et al. 2022

MedComm

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CD4 + CD25 + regulatory T cells (Tregs), a subpopulation of naturally CD4 + T cells that characteristically express transcription factor Forkhead box P3 (FOXP3), play a pivotal role in the maintenance of immune homeostasis and the prevention of autoimmunity. With the development of biological technology, the understanding of plasticity and stability of Tregs has been further developed. Recent studies have suggested that human Tregs are functionally and phenotypically diverse. The functions and mechanisms of different phenotypes of Tregs in different disease settings, such as tumor microenvironment, autoimmune diseases, and transplantation, have gradually become hot spots of immunology research that arouse extensive attention. Among the complex functions, CD4 + CD25 + FOXP3 + Tregs possess a potent immunosuppressive capacity and can produce various cytokines, such as IL‐2, IL‐10, and TGF‐β, to regulate immune homeostasis. They can alleviate the progression of diseases by resisting inflammatory immune responses, whereas promoting the poor prognosis of diseases by helping cells evade immune surveillance or suppressing effector T cells activity. Therefore, methods for targeting Tregs to regulate their functions in the immune microenvironment, such as depleting them to strengthen tumor immunity or expanding them to treat immunological diseases, need to be developed. Here, we discuss that different subpopulations of Tregs are essential for the development of immunotherapeutic strategies involving Tregs in human diseases.

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Section: Treg Subsets In Autoimmune Diseasementioning

confidence: 99%

Different subpopulations of regulatory T cells in human autoimmune disease, transplantation, and tumor immunity

Jiang

Zhu

Wang

et al. 2022

MedComm

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“…It has been shown that the interaction of TIM-1 with the antagonist ligands is a stimulating factor for suppressor T-regulatory cells (Тreg) [43]. The reduced TIM-1 expression on the Тreg cells is noted in patients with diabetes mellitus type I [44]. TIM-1 expression is typical for one of the regulatory B cells (Breg) subpopulations producing IL-10, the main negative regulator of the inflammatory response [45,46].…”

Section: Kim-1 and Immune Reactionsmentioning

confidence: 99%

Kidney Injury Molecule 1 (KIM-1): a Multifunctional Glycoprotein and Biological Marker (Review)

Karmakova¹,

Сергеева²,

Kanukoev³

et al. 2021

Sovrem Tehnol Med

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KIM-1 (kidney injury molecule 1) is a transmembrane glycoprotein also known as HAVcr-1 and TIM-1 belongs to the T-cell immunoglobulin and mucin domain family (TIM) of proteins. TIM glycoproteins are presented on the immune cells and participate in the regulation of immune reactions. KIM-1 differs from other members of its family in that it is expressed not only by immunocompetent cells but epithelial cells as well. Cellular and humoral effects mediated by KIM-1 are involved in a variety of physiological and pathophysiological processes.Current understanding of the mechanisms determining the participation of KIM-1 in viral invasion, the immune response regulation, adaptive reactions of the kidney epithelium to acute ischemic or toxic injury, in progression of chronic renal diseases, and kidney cancer development have been presented in this review. Data of clinical researches demonstrating the association of KIM-1 with viral diseases and immune disorders have also been analyzed. Potential application of KIM-1 as urinary or serological marker in renal and cardiovascular diseases has been considered.

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“…Tim-1 and Tim-4 are considered essential for the activation and differentiation of T lymphocytes. Guo et al evaluated the expression of Tim-1 and Tim-4 in Tregs and found that the numbers of Tim-1 + Tregs and Tim-4 + Tregs were significantly decreased in both patients with T1D and no obesity diabetes (NOD) mice (55).…”

Section: Tims and T1dmentioning

confidence: 99%

Novel Roles of the Tim Family in Immune Regulation and Autoimmune Diseases

Liu

Chen

et al. 2021

Front. Immunol.

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T cell Ig and mucin domain (Tim) protein family members were identified to be important regulators of the immune response. As their name indicates, Tim proteins were originally considered a T cell-specific markers, and they mainly regulate the responses of T helper cells. However, accumulating evidence indicates that Tims are also expressed on antigen-presenting cells (APCs), such as monocytes, macrophages, dendritic cells (DCs) and B cells, and even plays various roles in natural killer cells (NKs) and mast cells. In recent years, the expression and function of Tims on different cells and the identification of new ligands for the Tim family have suggested that the Tim family plays a crucial role in immune regulation. In addition, the relationship between Tim family gene polymorphisms and susceptibility to several autoimmune diseases has expanded our knowledge of the role of Tim proteins in immune regulation. In this review, we discuss how the Tim family affects immunomodulatory function and the potential role of the Tim family in typical autoimmune diseases, including multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and type 1 diabetes (T1D). A deeper understanding of the immunoregulatory mechanism of the Tim family might provide new insights into the clinical diagnosis and treatment of autoimmune diseases.

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The expression of Tim-1 and Tim-4 molecules in regulatory T cells in type 1 diabetes

Cited by 8 publications

References 20 publications

Different subpopulations of regulatory T cells in human autoimmune disease, transplantation, and tumor immunity

Different subpopulations of regulatory T cells in human autoimmune disease, transplantation, and tumor immunity

Kidney Injury Molecule 1 (KIM-1): a Multifunctional Glycoprotein and Biological Marker (Review)

Novel Roles of the Tim Family in Immune Regulation and Autoimmune Diseases

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