Kidney Injury Molecule 1 (KIM-1): a Multifunctional Glycoprotein and Biological Marker (Review)

Karmakova, Tatyana; Сергеева, Н. С.; Kanukoev, K. Yu.; Alekseev, B. Ya.; Каприн, А. Д.

doi:10.17691/stm2021.13.3.08

Cited by 46 publications

(34 citation statements)

References 139 publications

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“…Hypoxia is a powerful stimulus for KIM-1 expression in the proximal tubular cells. The upregulation of KIM-1 increases the release of cytokines and chemokines, that enhances inflammation, hypoxia and fibrosis, thus aggravating the CKD [ 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

A Mixture of Pure, Isolated Polyphenols Worsens the Insulin Resistance and Induces Kidney and Liver Fibrosis Markers in Diet-Induced Obese Mice

et al. 2022

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Obesity is a worldwide epidemic with severe metabolic consequences. Polyphenols are secondary metabolites in plants and the most abundant dietary antioxidants, which possess a wide range of health effects. The most relevant food sources are fruit and vegetables, red wine, black and green tea, coffee, virgin olive oil, and chocolate, as well as nuts, seeds, herbs, and spices. The aim of this work was to evaluate the ability of a pure, isolated polyphenol supplementation to counteract the pernicious metabolic effects of a high-fat diet (HFD). Our results indicated that the administration of pure, isolated polyphenols under HFD conditions for 26 weeks worsened the glucose metabolism in diet-induced obese mice. The data showed that the main target organ for these undesirable effects were the kidneys, where we observed fibrotic, oxidative, and kidney-disease markers. This work led us to conclude that the administration of pure polyphenols as a food supplement would not be advisable. Instead, the ingestion of complete “whole” foods would be the best way to get the health effects of bioactive compounds such as polyphenols.

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Section: Discussionmentioning

confidence: 99%

A Mixture of Pure, Isolated Polyphenols Worsens the Insulin Resistance and Induces Kidney and Liver Fibrosis Markers in Diet-Induced Obese Mice

et al. 2022

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“…Therefore, it was suggested that the phagocytotic function of KIM-1 may be adapted by RCC cells to clear tumor apoptotic bodies, thus preventing the activation of APCs and T lymphocytes against RCC cells. In other words, KIM-1 may play a scavenger role in RCC against potential immune reactions and may be a key factor in the tumor microenvironment for the survival and development of RCC (14)(15)(16)(17). KIM-1 overexpression in the cells of clear cell and papillary RCC has for a long time been known as a special feature of kidney tumors, but data concerning the clinical significance of increased KIM-1 expression in the extra-renal tumors are ambiguous.…”

Section: Discussionmentioning

confidence: 99%

“…TIM-1, one of these proteins, is homologous to KIM-1. In summary, the definitions of HAVcr-1, KIM-1 and TIM-1 (CD365) mentioned in the biological databases today describe the same protein (14)(15)(16). KIM-1 is normally expressed at a low level in the healthy kidney.…”

Section: Introductionmentioning

confidence: 99%

“…KIM-1 is normally expressed at a low level in the healthy kidney. However, cell-associated KIM-1 expression increases dramatically in post-ischemic kidney tissue and KIM-1 exerts an anti-inflammatory role following kidney injury (16,17). Its expression is also up-regulated in several human cancers, most notably in renal and ovarian carcinomas, but has very restricted expression in healthy tissues, thus representing a promising target for antibody-mediated therapy.…”

Section: Introductionmentioning

confidence: 99%

“…This antibody (CDX-O14) was shown to bind purified recombinant chimeric TIM-1-Fc protein and TIM-1 expressed on a variety of transformed cell lines. However, it has not been included in the routine treatment regimen to date (14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tissue Expression of Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Breast Cancers

Diniz¹,

Pulular²,

Kahraman³

et al. 2022

EJBH

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This study has demonstrated that the positivity of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) will be effective on breast cancer, especially in situ component-rich ones. •This result showed that NGAL and KIM-1 may be effective during the early carcinogenesis of breast cancer.• Recently the new immune modulatory drug for TIM-1.• Considering the development of anti-KIM-1 therapies, the presence of KIM-1 expression may be a new treatment option in breast cancer.

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Biomarkers Associated With Severe COVID-19 Among Populations With High Cardiometabolic Risk

et al. 2023

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ImportanceCardiometabolic parameters are established risk factors for COVID-19 severity. The identification of causal or protective biomarkers for COVID-19 severity may facilitate the development of novel therapies.ObjectiveTo identify protein biomarkers that promote or reduce COVID-19 severity and that mediate the association of cardiometabolic risk factors with COVID-19 severity.Design, Setting, and ParticipantsThis genetic association study using 2-sample mendelian randomization (MR) was conducted in 2022 to investigate associations among cardiometabolic risk factors, circulating biomarkers, and COVID-19 hospitalization. Inputs for MR included genetic and proteomic data from 4147 participants with dysglycemia and cardiovascular risk factors collected through the Outcome Reduction With Initial Glargine Intervention (ORIGIN) trial. Genome-wide association study summary statistics were obtained from (1) 3 additional independent plasma proteome studies, (2) genetic consortia for selected cardiometabolic risk factors (including body mass index [BMI], type 2 diabetes, type 1 diabetes, and systolic blood pressure; all n &gt;10 000), and (3) the COVID-19 Host Genetics Initiative (n = 5773 hospitalized and 15 497 nonhospitalized case participants with COVID-19). Data analysis was performed in July 2022.ExposuresGenetically determined concentrations of 235 circulating proteins assayed with a multiplex biomarker panel from the ORIGIN trial for the initial analysis.Main Outcomes and MeasuresHospitalization status of individuals from the COVID-19 Host Genetics Initiative with a positive COVID-19 test result.ResultsAmong 235 biomarkers tested in samples totaling 22 101 individuals, MR analysis showed that higher kidney injury molecule-1 (KIM-1) levels reduced the likelihood of COVID-19 hospitalization (odds ratio [OR] per SD increase in KIM-1 levels, 0.86 [95% CI, 0.79-0.93]). A meta-analysis validated the protective association with no observed directional pleiotropy (OR per SD increase in KIM-1 levels, 0.91 [95% CI, 0.88-0.95]). Of the cardiometabolic risk factors studied, only BMI was associated with KIM-1 levels (0.17 SD increase in biomarker level per 1 kg/m2 [95% CI, 0.08-0.26]) and COVID-19 hospitalization (OR per 1-SD biomarker level, 1.33 [95% CI, 1.18-1.50]). Multivariable MR analysis also revealed that KIM-1 partially mitigated the association of BMI with COVID-19 hospitalization, reducing it by 10 percentage points (OR adjusted for KIM-1 level per 1 kg/m2, 1.23 [95% CI, 1.06-1.43]).Conclusions and RelevanceIn this genetic association study, KIM-1 was identified as a potential mitigator of COVID-19 severity, possibly attenuating the increased risk of COVID-19 hospitalization among individuals with high BMI. Further studies are required to better understand the underlying biological mechanisms.

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Kidney Injury Molecule 1 (KIM-1): a Multifunctional Glycoprotein and Biological Marker (Review)

Cited by 46 publications

References 139 publications

A Mixture of Pure, Isolated Polyphenols Worsens the Insulin Resistance and Induces Kidney and Liver Fibrosis Markers in Diet-Induced Obese Mice

A Mixture of Pure, Isolated Polyphenols Worsens the Insulin Resistance and Induces Kidney and Liver Fibrosis Markers in Diet-Induced Obese Mice

Tissue Expression of Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Breast Cancers

Biomarkers Associated With Severe COVID-19 Among Populations With High Cardiometabolic Risk

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