The Expression of p53, p21 and TGF .BETA.1 in Gastric Carcinoma

Aoyagi, Keishiro; Koufuji, Kikuo; Yano, Shoichiro; Murakami, Naotaka; Miyagi, Motoshi; Koga, Atsuhiko; Takeda, Jinryo; Shirouzu, Kazuo

doi:10.2739/kurumemedj.50.1

Cited by 14 publications

(19 citation statements)

References 18 publications

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“…This was also true of the relationship between the nuclear-type p21 localization and PCNA expression. This finding is compatible with the weak association observed in astrocytoma (1). This positive association may be expected in view of the fact that p21 can bind to PCNA and inhibits DNA replication by controlling cell cycle progression (2).…”

Section: Discussionsupporting

confidence: 79%

“…Lai et al (9) have reported that MM patients with greater tumor burden are more likely to express p21. In contrast, Aoyagi et al (1) reported that in gastric carcinoma patients, the survival curve of the p21-positive group was significantly higher than that of the p21-negative group and the finding was supported by Seo et al (18). In ovarian cancer, negative or weak p21 staining was a prognostic indicator of short overall survival (11).…”

Section: Discussioncontrasting

confidence: 38%

“…The cell cycle inhibitory activity of p21 has been correlated with its nuclear localization (2). Several studies have evaluated the prognostic significance of p21 in hematopoietic (22,24) and solid (1,7,8,11,13,18,19) tumors, but the prognostic evaluation in MM remains to be explored (6,9,15).…”

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confidence: 99%

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Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

et al. 2005

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Protein p21 (Waf1/Cip1) plays a critical role in controlling the cell cycle especially as a check point of G1 and is intimately associated with important cellular activities including differentiation, senescence, tumorigenesis, and apoptosis. In the present study, we examined the expression of p21 in multiple myeloma (MM) cells for prognostic evaluation. The immunocytochemical localization of p21 could be categorized into nuclear and cytoplasmic types. The nuclear-type p21 localization was correlated with the severity of MM and the expression of proliferating cell nuclear antigen and p53. Patients with the nuclear-type p21 localization survived significantly shorter than those with the cytoplasmic-type localization. Thus, the present study suggests that p21-immunolocalization can be a useful prognostic marker of MM.

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Section: Discussionsupporting

confidence: 79%

Section: Discussioncontrasting

confidence: 38%

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Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

et al. 2005

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“…16 Moreover, the increased expression of mutated p53 has been associated with pathological parameters of tumor aggressiveness and poor prognosis in human gastric carcinomas. 1,8,26,30,47 Such a relationship has not been demonstrated in canine gastrointestinal tumors, although high p53 expression has been reported.…”

mentioning

confidence: 95%

“…1,16,37,47 No studies have been published regarding p21 expression in canine gastric carcinomas. The lack of p21 expression, as well as an over expression have been reported in other types of neoplasms in the dog.…”

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confidence: 99%

Canine Gastric Carcinoma

et al. 2010

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Immunohistochemical staining for cell cycle proteins and heat shock proteins was performed on 17 canine gastric carcinomas. The immunoexpression of p53, p21, p16, Hsp27, and Hsp70 was investigated. A study was conducted to determine the histological type and parameters related to tumor malignancy. Possible associations and trends were assessed between the immunoexpression of each protein and tumor type as well as specific parameters of malignancy. High intratumor frequency of cellular p53 immunostaining was observed (61.96% average), but lower frequencies of p21 and p16 expression were present (34.65% and 10.41%, respectively). The p53 overexpression was associated with tumor infiltration (P ¼ .0258). Expression of p21 was lower in undifferentiated carcinomas, and the loss of expression was associated with histopathological parameters characteristic of a poor prognosis such as lymphatic vessel invasion (P ¼ .0258). The lack of p16 immunoreactivity was related to histopathological characteristics of malignancy such as the presence of evident and multiple nucleoli (P ¼ .0475). In contrast, deep tumor infiltration was observed in those carcinomas with a high p16 index (P ¼ .0475). Hsp70 appeared to be overexpressed in all gastric neoplasms included in this study. This is in contrast to Hsp27, because a group of tumors showed complete lack of Hsp27 immunoexpression, whereas the others displayed extensive Hsp27 immunostaining. The differences in Hsp27 did not correlate with any of the histopathological parameters, but Hsp27 immunoexpression was higher in the undifferentiated carcinoma. No significant differences in the expression of the proteins were found in canine gastric carcinomas according to their histological type. These findings may be useful for establishing a prognosis for canine gastric carcinoma.

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The prognostic significance of p53, p27^kip1, p21^waf1, HER‐2/neu, and Ki67 proteins expression in gastric cancer: A clinicopathological and immunohistochemical study of 121 Arab patients

Al-Moundhri

Nirmala

Al-Hadabi

et al. 2005

Journal of Surgical Oncology

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The Expression of p53, p21 and TGF .BETA.1 in Gastric Carcinoma

Cited by 14 publications

References 18 publications

Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

Canine Gastric Carcinoma

The prognostic significance of p53, p27^kip1, p21^waf1, HER‐2/neu, and Ki67 proteins expression in gastric cancer: A clinicopathological and immunohistochemical study of 121 Arab patients

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The Expression of p53, p21 and TGF .BETA.1 in Gastric Carcinoma

Cited by 14 publications

References 18 publications

Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

Canine Gastric Carcinoma

The prognostic significance of p53, p27kip1, p21waf1, HER‐2/neu, and Ki67 proteins expression in gastric cancer: A clinicopathological and immunohistochemical study of 121 Arab patients

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The prognostic significance of p53, p27^kip1, p21^waf1, HER‐2/neu, and Ki67 proteins expression in gastric cancer: A clinicopathological and immunohistochemical study of 121 Arab patients