The prognostic significance of p53, p27kip1, p21waf1, HER‐2/neu, and Ki67 proteins expression in gastric cancer: A clinicopathological and immunohistochemical study of 121 Arab patients

Al-Moundhri, Mansour; Nirmala, V; Al-Hadabi, Ibrahim; Al-Mawaly, K.; Burney, Ikram A.; Al-Nabhani, M.; Thomas, Valsa; Ganguly, Shyam S.; Grant, Christopher S.

doi:10.1002/jso.20324

Cited by 57 publications

(63 citation statements)

References 51 publications

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“…The correlation between lymph node invasion and hyperexpression of p21 ras may be useful for selecting therapeutic alternatives for patients with p21 ras -negative tumors (23,24). A significant increase in the incidence of lymph node invasion was observed in cases with marked immunohistochemical positivity for p53 in tumor samples (P= 0.042), as previously documented (4,5).…”

Section: Kip1supporting

confidence: 70%

“…This is a conflicting result compared with previous reports (30,31). Although the expression of p16 ink4a is altered in gastric tumors, this alteration is considered to be secondary to p53 mutations (5). In normal mucosa, the expression of p16 ink4a has been reported to be low (32).…”

Section: Kip1mentioning

confidence: 99%

“…, p27 kip1 and p16 ink4a currently appear to be inherently correlated with gastric cancer behavior (4)(5)(6)(7)(8). These markers are differentially expressed, depending on the gastric carcinoma type (9).…”

Section: Introductionmentioning

confidence: 99%

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Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma

et al. 2017

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Abstract.wafl/cip1 was positive in 32.4, 72.7 and 71.4% of the cases, respectively. All the tumors were positive for p53. Tumors with lymph node invasion presented with overexpression (+4) of p53 in 47% of the cases vs. 17% of patients who did not have lymph node involvement. Therefore, higher expression of p53, p21 ras and p21 wafl/cip1 in the tumor exhibited a statistically significant association with lymph node involvement.

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Section: Kip1supporting

confidence: 70%

Section: Kip1mentioning

confidence: 99%

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Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma

et al. 2017

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“…Any increase in parts of genome containing oncogenes, such as HER-2/neu, would play a key role in the onset and development of tumors (16,17). Overexpression of HER-2/neu gene has been reported in 92-95% of gastric cancer cases (18,19).…”

Section: Discussionmentioning

confidence: 99%

HER-2/neu gene amplification in gastric adenocarcinoma and its relationship with clinical and pathological findings

Azarhoosh

Ebneghasem

Besharat

2017

J. Gastrointest. Oncol.

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Background: Amplification of the HER-2/neu oncogene influences the progression of gastric cancer, its prognosis, and therapy. A precise examination of HER-2/neu-amplified tumor tissue is essential for managing disease and prescribing the appropriate treatment. This study aimed to investigate the status of HER-2/neu gene in the gastric cancer samples and its relationship with clinical and pathological information. Methods: In this study on 80 paraffin-embedded tissue samples from patients with gastric adenocarcinoma [2006][2007][2008][2009][2010][2011], DNA was extracted to quantify the gene expression levels of HER-2 using a polymerase chain reaction (PCR) method. Data were statistically analyzed by chi-square test using SPSS16.0 software. Results: PCR results indicated that HER-2/neu gene amplifications occurred in 58 of the 80 samples (72.5%). HER-2/neu gene expression was not significantly related to age and sex, but the larger tumor size and the more advanced stage were significantly associated with HER-2/neu overexpression. Conclusions:The data show the HER-2/neu gene is more amplified in stage 4 of gastric cancer with a larger size of mass. Older age and male sex also appear to be more associated with HER-2/neu gene expression.

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“…The prognosis of patients with gastric cancer has been shown to be influenced by established surgical-pathological features, such as pathological stage, location of the tumor, and histological type and grade of the tumor [2][3][4] . In comparison, the intense search for predictive molecular biomarkers has not yet translated into clinical use [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Measurement of circulating levels of VEGF-A, -C, and -D and their receptors, VEGFR-1 and -2 in gastric adenocarcinoma

Al-Moundhri¹,

Al-Shukaili²,

Al-Nabhani³

et al. 2008

WJG

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AIM:To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A, -C, and -D, and their receptors, VEGFR-1 and -2 in gastric adenocarcinomas. METHODS:The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS:The serum levels of VEGF-A and its receptor, VEGFR-1, were significantly higher in patients with gastric cancer than in healthy donors (t = 2.3, P = 0.02 and t = 4.2, P < 0.0001, respectively). In contrast, the serum levels of VEGF-D were significantly higher in control subjects than in patients (t = 2.9,

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The prognostic significance of p53, p27^kip1, p21^waf1, HER‐2/neu, and Ki67 proteins expression in gastric cancer: A clinicopathological and immunohistochemical study of 121 Arab patients

Abstract: The expression of p53 in Arab patients with GC correlates with aggressive tumor characteristics and is an independent prognostic factor. The combined analysis of p53 and p27 kip1 is of added prognostic value.

Cited by 57 publications

References 51 publications

Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma

Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma

HER-2/neu gene amplification in gastric adenocarcinoma and its relationship with clinical and pathological findings

Measurement of circulating levels of VEGF-A, -C, and -D and their receptors, VEGFR-1 and -2 in gastric adenocarcinoma

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