The Erythropoietic Effects of Anabolic Steroids.

Duarte, Lorenzo; Medal, L Sánchez; Labardini, Juan; Arriaga, Luis

doi:10.3181/00379727-125-32268

Cited by 15 publications

(5 citation statements)

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“…This finding indicates that an erythropoiesis stimulating activity of testosterone may not directly related to its virilizing effect. D u a r te et al have also reported similar results [9]. Cyproterone acetate used in these experiments has no estrogenic effect but blocking activity of androgen receptor in target organ [10,11].…”

Section: Commentsupporting

confidence: 68%

Effect of Androgen Antagonist on Erythropoietic Action of Testosterone

Shirakura¹,

Azuma²,

Maekawa³

1968

Acta Haematol

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Section: Commentsupporting

confidence: 68%

Effect of Androgen Antagonist on Erythropoietic Action of Testosterone

Shirakura¹,

Azuma²,

Maekawa³

1968

Acta Haematol

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“…Haemopoiesis in experimental animals is stimulated by exogenous adrogenic and anabolic hormones (Duarte et al 1967;Upuda & Reissmann 1974;Modder e t al. 1978;Porcelili et al 1978).…”

Section: Discussionmentioning

confidence: 99%

“…Anabolic (including androgenic) hormones are capable of stimulating erythropoiesis in both experimental animals and in patients with various forms of anaemia (Duarte et al 1967;Kennedy 1977;Modder et al 1978;Porcellini et al 1978). Such hormones can also reduce the toxic effects of cytostatic agents on erythropoiesis in rats and monkeys (Folsch et al 1975;Ambrus er al.…”

mentioning

confidence: 99%

Anabolic Stimulation of Blood Cell Count Recovery after Chlorambucil‐Induced Myelosuppression in Rats

Miintzing

1981

Acta Pharmacologica et Toxicologica

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Abstruci:The recovery of leukocyte concentration in blood after chlorambucil(C)-induced leukopenia was more rapid in intact than in castrated male rats. The enhancement of recovery caused by testicular hormones could be mimicked in orchiectomized animals by administration of 19-nortestosterone hexyloxyphenylpropionate (NT) (Anadura) given prior to but not after C. NT given prior to C also resulted in higher erythrocyte concentrations and packed blood cell volumes than in animals given only C. NT could not diminish the leukopeniainduced by repeated administrations of C. A stimulation by NT of leukocyte count recovery also in patients might be of clinical importance especially in patients subjected to intermittent treatment with cytostatic agents.

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“…AASs-induced erythrocytosis has been long known as a consequence of testosterone administration, at least since the 1967. 35 Basically, renal tissue responds to androgen stimulation very similarly to the muscle, so that the androgen receptors located in the kidneys are responsible for increasing the stimulation of RBC production (i.e., erythropoiesis). As such, Alén studied five power athletes undergoing steroid administration during 26 weeks of training, reporting a 9.6% increase in hematocrit, which was mainly attributed to increased number of RBC as the mean corpuscular volume remained unchanged.…”

Section: Doping and Thrombosis In Sports/lippi Banfimentioning

confidence: 99%

Doping and Thrombosis in Sports

Lippi

Banfi

2011

Semin Thromb Hemost

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Historically, humans have long sought to enhance their "athletic" performance to increase body weight, aggressiveness, mental concentration and physical strength, contextually reducing fatigue, pain, and improving recovery. Although regular training is the mainstay for achieving these targets, the ancillary use of ergogenic aids has become commonplace in all sports. The demarcation between ergogenic aids and doping substances or practices is continuously challenging and mostly based on perceptions regarding the corruption of the fairness of competition and the potential side effects or adverse events arising from the use of otherwise unnecessary ergogenic substances. A kaleidoscope of side effects has been associated with the use of doping agents, including behavioral, skeletal, endocrinologic, metabolic, hemodynamic, and cardiovascular imbalances. Among the various doping substances, the most striking association with thrombotic complications has been reported for androgenic anabolic steroids (i.e., cardiomyopathy, fatal and nonfatal arrhythmias, myocardial infarction [MI], intracardiac thrombosis, stroke, venous thromboembolism [VTE], limb arterial thrombosis, branch retinal vein occlusion, cerebral venous sinus thrombosis) and blood boosting (i.e., VTE and MI, especially for epoetin and analogs). The potential thrombotic complication arising from misuse of other doping agents such as the administration of cortisol, growth hormone, prolactin, cocaine, and platelet-derived preparations is instead speculative or anecdotal at best. The present article provides an overview on the epidemiological association as well as the underlying biochemical and biological mechanisms linking the practice of doping in sports with the development of thrombosis.

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The Erythropoietic Effects of Anabolic Steroids.

Cited by 15 publications

References 0 publications

Effect of Androgen Antagonist on Erythropoietic Action of Testosterone

Effect of Androgen Antagonist on Erythropoietic Action of Testosterone

Anabolic Stimulation of Blood Cell Count Recovery after Chlorambucil‐Induced Myelosuppression in Rats

Doping and Thrombosis in Sports

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