Abstruci:The recovery of leukocyte concentration in blood after chlorambucil(C)-induced leukopenia was more rapid in intact than in castrated male rats. The enhancement of recovery caused by testicular hormones could be mimicked in orchiectomized animals by administration of 19-nortestosterone hexyloxyphenylpropionate (NT) (Anadura) given prior to but not after C. NT given prior to C also resulted in higher erythrocyte concentrations and packed blood cell volumes than in animals given only C. NT could not diminish the leukopeniainduced by repeated administrations of C. A stimulation by NT of leukocyte count recovery also in patients might be of clinical importance especially in patients subjected to intermittent treatment with cytostatic agents.
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