Enzyme Activity and Distribution in the Hyperplastic and Cancerous Human Prostate

Miintzing, Jonas; Nilsson, T.

doi:10.3109/00365597209133620

Cited by 18 publications

(5 citation statements)

References 10 publications

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“…Acid phosphatase from the human prostate can be demonstrated in the blood with immunological techniques [29] . Histochemically acid phosphatase could sometimes be demonstrated in the stroma adjacent to the acini [30,31].…”

Section: Exogenousmentioning

confidence: 99%

Androgen and collagen as growth regulators of the rat ventral prostate

Müntzing

1980

The Prostate

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With the aim of studying a possible role of the fibromuscular stroma as growth regulator for the rat ventral prostate the weight, DNA content, and hydroxyproline content were analyzed in the ventral prostate of rats of varying age. Exogenous androgen increased the age-dependent weight and contents only in young and old rats. Orchiectomy reduced prostatic weight, DNA content, and hydroxyproline content although to different extent, and exogenous androgen restored the weight and contents. Exogenous estrogen to intact animals had effects similar to orchiectomy. Estrogen combined with androgen increased DNA content over that found in animals given androgen only, while weight and hydroxyproline content were not changed. It is concluded that the endogenous androgen determines the size of the prostate in young and old animals. Androgen also determines prostatic collagen content. The good correlation between prostatic DNA and hydroxyproline indicates a more or less fixed number of epithelial cells per amount of collagen. A hypothesis suggesting a crucial role for prostatic collagen in the growth-limiting mechanism in the prostate is presented.

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Section: Exogenousmentioning

confidence: 99%

Androgen and collagen as growth regulators of the rat ventral prostate

Müntzing

1980

The Prostate

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“…Ilowever, in hyperplasia a wide range of amino peptidase activity is demonstrated and little to no activity might be found as is pointed out by among others, Niemi et al (1963). The amino peptidase activity determined biochemically does not support its use for diagnosis, as activity is found in both cancerous and noncancerous tissue to varying degrees (Muntzing and Nilsson, 1972a) (Table I). I 84 18 35 8 2 2 33 69 20 27 2 2 17 2 10 7 2 …”

Section: Resultsmentioning

confidence: 96%

Some biochemical and histochemical aspects in hyperplasia and carcinoma of the human prostate

Nilsson

Müntzing

1973

Journal of Surgical Oncology

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A study of histochemical and biochemical enzyme activity determination in hyperplastic and untreated carcinomatous prostatic tissue is presented. The histochemical results are in agreement with earlier investigations and the biochemical findings corroborate grossly the histochemical findings. A comparison of conventional estrogen therapy to Estramustine phosphate, (EstracytR), therapy is discussed from both the histochemical and biochemical points of view. The enzyme activity quotient, acid phosphatase lo 0-glucuronidase, is pointed out as a possible indicator in following the therapeutic response, and in determination of the origin of metastases. Lipofuscin pigment is demonstrated to a much higher frequency after Estracyt treatment than after conventional estrogen treatment. This indicates that this substance might have an intracellular effect which is different and more pronounced that than of estrogen.

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“…There are many mechanisms by which BPH leads to BLCA. The ratio of acid phosphatase to β -glucuronidase in the urine of patients with prostate cancer was only 10% effective in those having BPH ( Muntzing and Nilsson, 1972 ). BPH causes lower urinary tract obstruction, poor urination, urinary retention, and increased β -glucuronidase activity in urine, which decomposes β -naphthylamine, 4-aminobiphenyl, and benzidine, that do not easily and directly cause carcinogenesis by being converted into 2-amino-1 naphthol that is a carcinogen, thus significantly prolonging the contact time between some carcinogens and bladder mucosa ( Melicow et al, 1961 ).…”

Section: Discussionmentioning

confidence: 99%

Genetically supported causality between benign prostate hyperplasia and urinary bladder neoplasms: A mendelian randomization study

Wang²,

Zhang³

et al. 2022

Front. Genet.

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Background: Observational studies have suggested a possible association between benign prostate hyperplasia (BPH) and bladder cancer (BLCA). However, these studies are prone to errors and limitations or confounding factors, making them unsuitable for assessing the causal relationship between BPH and BLCA.Objective: Two-sample Mendelian randomization (MR) was performed to determine a possible association between genetically predicted BPH and the risk of BLCA.Methods: A two-sample MR analysis was performed utilizing the Integrative Epidemiology Unit genome-wide association (GWAS) database of the Medical Research Council, United Kingdom A series of control steps, including five primary methods, were performed to identify the most suitable instrumental variables (IVs) for MR analysis. Sensitivity analysis was conducted to avoid statistical errors, including heterogeneity and pleiotropic bias.Results: Genetic variants associated with BPH (P < 5 × 10–8) and BLCA (P < 5 × 10–6) were identified as instrumental variables and assessed using GWAS summary data (BPH, 4,670 cases vs. 458,340 controls; BLCA, 1,279 cases vs. 372,016 controls). BPH exhibited a positive effect on the occurrence of BLCA (inverse variance weighted (IVW), odds ratio (OR) = 1.095, 95% confidence interval (CI) = 1.030–1.165, p = 0.003), but there was no causal effect for BLCA on BPH (IVW, OR = 1.092, 95% CI = 0.814–1.465, p = 0.554).Conclusion: Genetically predicted BPH was associated with a higher risk of BLCA in all histological subtypes. In contrast, the evidence was not significant to back the causality of genetically induced BLCA on BPH. These findings indicate that BPH plays a key role in developing BLCA in the European population. Further studies are needed to uncover the underlying mechanisms.

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Enzyme Activity and Distribution in the Hyperplastic and Cancerous Human Prostate

Cited by 18 publications

References 10 publications

Androgen and collagen as growth regulators of the rat ventral prostate

Androgen and collagen as growth regulators of the rat ventral prostate

Some biochemical and histochemical aspects in hyperplasia and carcinoma of the human prostate

Genetically supported causality between benign prostate hyperplasia and urinary bladder neoplasms: A mendelian randomization study

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