The Eradication of <i>Helicobacter pylori</i> does not Affect Glycemic Control in Japanese Subjects with Type 2 Diabetes

Wada, Yoshiharu; Hamamoto, Yoshiyuki; Kawasaki, Yukiko; Honjo, Sachiko; Fujimoto, Kanta; Tatsuoka, Hisato; Matsuoka, Atsuko; Ikeda, Hiroki; Fujikawa, Jun; Koshiyama, Hiroyuki

doi:10.4137/jcm.s10828

Cited by 16 publications

(20 citation statements)

References 4 publications

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“…Haeseker et al [19] did not demonstrate any positive association between H. pylori infection and DM, in contrast to some viruses such as EBV and HHV6, while Vafaeimanesh et al [20] showed that H. pylori eradication plays no role in the control of glycemia in type 2 DM patients. Similarly, Wada et al [21] found that H. pylori eradication did not affect glycemic control in Japanese patients with type 2 DM, at least during the 6-month observational period.…”

Section: Diabetes Mellitusmentioning

confidence: 88%

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Helicobacter pylori and Extragastric Diseases

Franceschi¹,

Tortora

Gasbarrini³

et al. 2014

Helicobacter

127

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While Helicobacter pylori infection was initially revealed to be associated only with some gastroduodenal diseases, further studies have shown its possible role in several extragastric diseases. For idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency, the diagnosis of H. pylori infection is recommended, and there are many other conditions such as cardiovascular, neurological, dermatological, and respiratory diseases in which H. pylori may possibly play a role. Interestingly, a potential role has also been described for GI neoplastic diseases, including colorectal and pancreatic cancer. Different mechanisms of action have been proposed, ranging from the induction of a low grade inflammatory state to the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic over the last year.

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Section: Diabetes Mellitusmentioning

confidence: 88%

“…Similarly, Wada et al. found that H. pylori eradication did not affect glycemic control in Japanese patients with type 2 DM, at least during the 6‐month observational period.…”

Section: Diabetes Mellitusmentioning

confidence: 90%

Helicobacter pylori and Extragastric Diseases

Franceschi¹,

Tortora

Gasbarrini³

et al. 2014

Helicobacter

127

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“…Few studies have examined the association between H. pylori eradication and diabetes. It was reported that H. pylori eradication improved the mean glycated hemoglobin in patients with type 2 diabetes, however, whether H. pylori eradication improves glycemic control is also controversial. Recent randomized trial showed that H. pylori eradication improves glucose homeostasis in patients with type 2 diabetes through a decrease in pro‐inflammatory factors.…”

Section: Discussionmentioning

confidence: 99%

Association between Helicobacter pylori infection, eradication and diabetes mellitus

Kato

Toda

Yamamoto‐Honda

et al. 2019

J of Diabetes Invest

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Aims/Introduction It is suspected that Helicobacter pylori is associated with extradigestive diseases including diabetes. So far, a number of studies have examined the association between H. pylori and diabetes, and the results were conflicting. The aim of the present study was to examine the association between H. pylori infection, eradication and diabetes. Materials and Methods The present cross‐sectional study was carried out using data from annual health checkups carried out at the Toranomon Hospital Health Management Center. The status of H. pylori infection, determined by serum antibodies and history of eradication, was categorized into three groups as “never,” “current” and “past.” The association between H. pylori infection and diabetes was examined using logistic regression. Results Of 21,634 participants, 6,530 (30.2%) had a current or past history of H. pylori infection, and 1,184 (5.5%) were identified as having diabetes. Multivariate adjusted odds ratios for diabetes compared with the “never” group were 1.36 (95% confidence interval 1.10–1.67) for the “current” group and 0.92 (95% confidence interval 0.79–1.07) for the “past” group. The association between H. pylori infection and diabetes was also observed among participants without a history of eradication. Conclusions We found that current H. pylori infection was associated with an increased risk of diabetes, and the increased risk was not observed among participants after eradication. The results were concordant with the hypothesis that H. pylori infection increases the risk of diabetes. Further studies are necessary to validate the present results.

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“…The discrepancy in results between the two meta-analyses can be explained by differences in their criteria of study selection, which determined the number and quality of the studies analyzed. The question of whether H. pylori eradication can improve glycemic control was assessed in a limited number of observational studies, most of them were small scale [95][96][97][98][99][100][101] (Table 3).…”

Section: H Pylori Infection and Diabetes Mellitusmentioning

confidence: 99%

Helicobacter pylori Infection and Diabetes Mellitus

Haj¹,

Raviv²,

Muhsen³

2016

Extradigestive Manifestations of Helicobacter Pylori Infection - An Overview

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Helicobacter pylori colonizes the stomach and causes chronic gastritis, which most often remains asymptomatic. However, in a small proportion of infected persons, it causes peptic ulcers and gastric cancer. We reviewed recent evidence of the association between H. pylori infection and diabetes mellitus DM . Numerous studies have shown a positive association between H. pylori infection and DM, however, findings are still conflicting. Such a link is biologically plausible, given the importance of the stomach in the homeostasis of systems outside the digestive tract however, the mechanisms by which H. pylori might affect the risk of DM are not clear. Current knowledge indicates that H. pylori infection can affect the regulation of ghrelin and leptin, two hormones that play central roles in energy homeostasis in humans. Yet, methodological limitations are present in studies that addressed the relationships of H. pylori infection with DM and with possible risk factors for DM, including inadequate control of confounders. The important question of whether H. pylori eradication might be beneficial for glycemic control in diabetic patients is still unresolved. Future well-designed studies are needed to address these research questions, which are of clinical and great public health significance.

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The Eradication of Helicobacter pylori does not Affect Glycemic Control in Japanese Subjects with Type 2 Diabetes

Cited by 16 publications

References 4 publications

Helicobacter pylori and Extragastric Diseases

Helicobacter pylori and Extragastric Diseases

Association between Helicobacter pylori infection, eradication and diabetes mellitus

Helicobacter pylori Infection and Diabetes Mellitus

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